eF-site ID 5zrf-B PDB Code 5zrf Chain B click to enlarge Title Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21 Classification ISOMERASE/DNA Compound DNA topoisomerase 2-beta Source (5ZRF) Sequence B:  SKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSG LGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIK IVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGL LINFIHHNWPSLLKHGFLEEFITPAKEAKEYFADMERHRI LFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRR LHGTKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQ RKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMM TIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYI FTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIP MVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPH PMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITEL PVRTWTQVYKEQVLEPMLNGPALISDYKEYHTDTTVKFVV KMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLK KYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNN QARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAW KEAQGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVND LKRKSPSDLWKEDLAAFVEELDKVESQERED Description Functional site 1) chain B residue 867 type sequence N description binding site for residue MG B 1301 source : AC3 2) chain B residue 868 type sequence G description binding site for residue MG B 1301 source : AC3 3) chain B residue 557 type sequence D description binding site for residue MG B 1302 source : AC4 4) chain B residue 559 type sequence D description binding site for residue MG B 1302 source : AC4 5) chain B residue 478 type sequence G description binding site for residue EVP D 101 source : AC5 6) chain B residue 479 type sequence D description binding site for residue EVP D 101 source : AC5 7) chain B residue 503 type sequence R description binding site for residue EVP D 101 source : AC5 8) chain B residue 778 type sequence Q description binding site for residue EVP D 101 source : AC5 9) chain B residue 782 type sequence M description binding site for residue EVP D 101 source : AC5 10) chain B residue 820 type sequence R description binding site for Di-nucleotide IU D 9 and DG D 10 source : AC9 11) chain B residue 821 type sequence Y description binding site for Di-nucleotide IU D 9 and DG D 10 source : AC9 12) chain B residue 505 type sequence K description binding site for Di-nucleotide DC D 14 and IU D 15 source : AD1 13) chain B residue 506 type sequence I description binding site for Di-nucleotide DC D 14 and IU D 15 source : AD1 14) chain B residue 507 type sequence L description binding site for Di-nucleotide DC D 14 and IU D 15 source : AD1 15) chain B residue 508 type sequence N description binding site for Di-nucleotide DC D 14 and IU D 15 source : AD1 16) chain B residue 516 type sequence Q description binding site for Di-nucleotide DC D 14 and IU D 15 source : AD1 17) chain B residue 564 type sequence H description binding site for Di-nucleotide DC D 14 and IU D 15 source : AD1 18) chain B residue 506 type sequence I description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 19) chain B residue 507 type sequence L description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 20) chain B residue 508 type sequence N description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 21) chain B residue 564 type sequence H description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 22) chain B residue 669 type sequence F description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 23) chain B residue 872 type sequence I description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 24) chain B residue 873 type sequence G description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 25) chain B residue 874 type sequence T description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 26) chain B residue 879 type sequence K description binding site for Di-nucleotide DC D 19 and IU D 20 source : AD3 27) chain B residue 1010 type sequence T description binding site for Di-nucleotide DC D 19 and IU D 20 source : AD3 28) chain B residue 1011 type sequence L description binding site for Di-nucleotide DC D 19 and IU D 20 source : AD3 29) chain B residue 1012 type sequence T description binding site for Di-nucleotide DC D 19 and IU D 20 source : AD3 30) chain B residue 1014 type sequence N description binding site for Di-nucleotide DC D 19 and IU D 20 source : AD3 31) chain B residue 479 type sequence D description binding site for Di-nucleotide IU F 9 and DG F 10 source : AD4 32) chain B residue 477 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 821 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 678 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 35) chain B residue 739 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 36) chain B residue 947 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 37) chain B residue 505 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 38) chain B residue 508 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 39) chain B residue 677 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 40) chain B residue 773 type SITE sequence Y description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI5 41) chain B residue 820 type SITE sequence R description Transition state stabilizer source Swiss-Prot : SWS_FT_FI6 42) chain B residue 872 type SITE sequence I description Important for DNA bending; intercalates between base pairs of target DNA source Swiss-Prot : SWS_FT_FI7 43) chain B residue 641 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 44) chain B residue 671 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 45) chain B residue 707 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 46) chain B residue 1087 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 47) chain B residue 638 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI9 48) chain B residue 557 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 49) chain B residue 559 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3

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