eF-site ID 5zni-A PDB Code 5zni Chain A click to enlarge Title Plasmodium falciparum purine nucleoside phosphorylase in complex with mefloquine Classification TRANSFERASE Compound Purine nucleoside phosphorylase Source (Q8T9Z7_PLAFA) Sequence A:  NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLA YNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNG AKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLI HGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYP NKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGI LIVDGCPFKHQLENMIKIALGACAKLATKYA Description (1)  Purine nucleoside phosphorylase (E.C.2.4.2.1) Functional site 1) chain A residue 23 type ligand sequence G description binding site for residue PO4 A 301 source : AC1 2) chain A residue 27 type ligand sequence R description binding site for residue PO4 A 301 source : AC1 3) chain A residue 45 type ligand sequence R description binding site for residue PO4 A 301 source : AC1 4) chain A residue 88 type ligand sequence R description binding site for residue PO4 A 301 source : AC1 5) chain A residue 90 type ligand sequence G description binding site for residue PO4 A 301 source : AC1 6) chain A residue 91 type ligand sequence S description binding site for residue PO4 A 301 source : AC1 7) chain A residue 7 type ligand sequence H description binding site for residue YMZ A 302 source : AC2 8) chain A residue 45 type ligand sequence R description binding site for residue YMZ A 302 source : AC2 9) chain A residue 92 type ligand sequence C description binding site for residue YMZ A 302 source : AC2 10) chain A residue 93 type ligand sequence G description binding site for residue YMZ A 302 source : AC2 11) chain A residue 160 type ligand sequence Y description binding site for residue YMZ A 302 source : AC2 12) chain A residue 181 type ligand sequence V description binding site for residue YMZ A 302 source : AC2 13) chain A residue 182 type ligand sequence E description binding site for residue YMZ A 302 source : AC2 14) chain A residue 183 type ligand sequence M description binding site for residue YMZ A 302 source : AC2 15) chain A residue 206 type ligand sequence D description binding site for residue YMZ A 302 source : AC2 16) chain A residue 207 type ligand sequence G description binding site for residue YMZ A 302 source : AC2 17) chain A residue 208 type ligand sequence C description binding site for residue YMZ A 302 source : AC2 18) chain A residue 209 type ligand sequence P description binding site for residue YMZ A 302 source : AC2 19) chain A residue 66 type binding ligand YMZ: Mefloquine sequence V description Mefloquine binding site source pdb_hetatom : YMZ_5zni_A_302 20) chain A residue 91-94 type binding ligand YMZ: Mefloquine sequence SCGS description Mefloquine binding site source pdb_hetatom : YMZ_5zni_A_302 21) chain A residue 157 type binding ligand YMZ: Mefloquine sequence S description Mefloquine binding site source pdb_hetatom : YMZ_5zni_A_302 22) chain A residue 159-160 type binding ligand YMZ: Mefloquine sequence MY description Mefloquine binding site source pdb_hetatom : YMZ_5zni_A_302 23) chain A residue 170 type binding ligand YMZ: Mefloquine sequence L description Mefloquine binding site source pdb_hetatom : YMZ_5zni_A_302 24) chain A residue 181-184 type binding ligand YMZ: Mefloquine sequence VEME description Mefloquine binding site source pdb_hetatom : YMZ_5zni_A_302 25) chain A residue 206-209 type binding ligand YMZ: Mefloquine sequence DGCP description Mefloquine binding site source pdb_hetatom : YMZ_5zni_A_302

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