eF-site ID 5zkq-A PDB Code 5zkq Chain A click to enlarge Title Crystal structure of the human platelet-activating factor receptor in complex with ABT-491 Classification SIGNALING PROTEIN Compound Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor Source (PTAFR_HUMAN) Sequence A:  HDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARL FNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKF LCNVAGCLFFINTYCSVAFLGVITYNRYQAVTRPQANTRK RGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGDVTR CFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRT LLMQPAEVKRRDLWMACTVLAVFIICFVPHHVVQLPWTLA ELGFQDSKFHQAINDAHQVTLCLLSTNCVLNPVIYCFLT Description Functional site 1) chain A residue 22 type sequence Y description binding site for residue 9EU A 501 source : AC1 2) chain A residue 73 type sequence W description binding site for residue 9EU A 501 source : AC1 3) chain A residue 77 type sequence Y description binding site for residue 9EU A 501 source : AC1 4) chain A residue 94 type sequence G description binding site for residue 9EU A 501 source : AC1 5) chain A residue 97 type sequence F description binding site for residue 9EU A 501 source : AC1 6) chain A residue 173 type sequence C description binding site for residue 9EU A 501 source : AC1 7) chain A residue 174 type sequence F description binding site for residue 9EU A 501 source : AC1 8) chain A residue 175 type sequence E description binding site for residue 9EU A 501 source : AC1 9) chain A residue 177 type sequence Y description binding site for residue 9EU A 501 source : AC1 10) chain A residue 188 type sequence H description binding site for residue 9EU A 501 source : AC1 11) chain A residue 191 type sequence I description binding site for residue 9EU A 501 source : AC1 12) chain A residue 252 type sequence Q description binding site for residue 9EU A 501 source : AC1 13) chain A residue 279 type sequence L description binding site for residue 9EU A 501 source : AC1 14) chain A residue 151 type sequence Y description binding site for residue OLC A 502 source : AC2 15) chain A residue 152 type sequence F description binding site for residue OLC A 502 source : AC2 16) chain A residue 178 type sequence E description binding site for residue OLC A 502 source : AC2 17) chain A residue 183 type sequence P description binding site for residue OLC A 502 source : AC2 18) chain A residue 190 type sequence F description binding site for residue OLC A 502 source : AC2 19) chain A residue 151 type sequence Y description binding site for residue OLC A 503 source : AC3 20) chain A residue 155 type sequence L description binding site for residue OLC A 503 source : AC3 21) chain A residue 156 type sequence D description binding site for residue OLC A 503 source : AC3 22) chain A residue 102 type sequence Y description binding site for residue OLC A 504 source : AC4 23) chain A residue 143 type sequence V description binding site for residue OLC A 504 source : AC4 24) chain A residue 144 type sequence A description binding site for residue OLC A 504 source : AC4 25) chain A residue 145 type sequence I description binding site for residue OLC A 504 source : AC4 26) chain A residue 194 type sequence S description binding site for residue OLC A 504 source : AC4 27) chain A residue 153 type sequence L description binding site for residue OLC A 505 source : AC5 28) chain A residue 4 type sequence H description binding site for residue ZN A 506 source : AC6 29) chain A residue 8 type sequence H description binding site for residue ZN A 506 source : AC6 30) chain A residue 259 type sequence E description binding site for residue ZN A 506 source : AC6 31) chain A residue 268 type sequence H description binding site for residue ZN A 506 source : AC6 32) chain A residue 272 type sequence N description binding site for residue ZN A 506 source : AC6 33) chain A residue 39-54 type TOPO_DOM sequence VFARLFNEIKI description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 114-133 type TOPO_DOM sequence NRYQAVTRPQANTRKR description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 55-74 type TRANSMEM sequence FMVNLTMADMLFLITLPLWI description Helical; Name=2 => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 36) chain A residue 75-91 type TOPO_DOM sequence VYYQNQGNWILPKFLCN description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 37) chain A residue 156-184 type TOPO_DOM sequence DSTNTVPDSAGSGDVTRCFEHYEKGSVPV description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 38) chain A residue 255-276 type TOPO_DOM sequence WTLAELGFQDSKFHQAINDAHQ description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 39) chain A residue 92-113 type TRANSMEM sequence VAGCLFFINTYCSVAFLGVITY description Helical; Name=3 => ECO:0000255 source Swiss-Prot : SWS_FT_FI5 40) chain A residue 134-155 type TRANSMEM sequence GISLSLVIWVAIVGAASYFLIL description Helical; Name=4 => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 41) chain A residue 185-205 type TRANSMEM sequence LIIHIFIVFSFFLVFLIILFC description Helical; Name=5 => ECO:0000255 source Swiss-Prot : SWS_FT_FI7 42) chain A residue 234-254 type TRANSMEM sequence ACTVLAVFIICFVPHHVVQLP description Helical; Name=6 => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 43) chain A residue 277-296 type TRANSMEM sequence VTLCLLSTNCVLNPVIYCFL description Helical; Name=7 => ECO:0000255 source Swiss-Prot : SWS_FT_FI9 44) chain A residue 169 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI10 45) chain A residue 103-119 type prosite sequence CSVAFLGVITYNRYQAV description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. CSVaFLGVITYNRYQaV source prosite : PS00237 46) chain A residue 17-38 type TRANSMEM sequence LFPIVYSIIFVLGVIANGYVLW description Helical; Name=1 => ECO:0000255 source Swiss-Prot : SWS_FT_FI1

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