eF-site ID 5zge-AB PDB Code 5zge Chain A, B click to enlarge Title Crystal structure of NDM-1 at pH5.5 (Bis-Tris) in complex with hydrolyzed ampicillin Classification HYDROLASE/ANTIBIOTIC Compound Metallo-beta-lactamase type 2 Source (BLAN1_KLEPN) Sequence A:  EIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPG FGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEI NLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLA PQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGH TSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHY AASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKL R B:  EIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPG FGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEI NLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLA PQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGH TSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHY AASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKL R Description Functional site 1) chain A residue 65 type sequence L description binding site for residue ZZ7 A 301 source : AC1 2) chain A residue 67 type sequence M description binding site for residue ZZ7 A 301 source : AC1 3) chain A residue 93 type sequence W description binding site for residue ZZ7 A 301 source : AC1 4) chain A residue 122 type sequence H description binding site for residue ZZ7 A 301 source : AC1 5) chain A residue 123 type sequence Q description binding site for residue ZZ7 A 301 source : AC1 6) chain A residue 124 type sequence D description binding site for residue ZZ7 A 301 source : AC1 7) chain A residue 189 type sequence H description binding site for residue ZZ7 A 301 source : AC1 8) chain A residue 208 type sequence C description binding site for residue ZZ7 A 301 source : AC1 9) chain A residue 211 type sequence K description binding site for residue ZZ7 A 301 source : AC1 10) chain A residue 219 type sequence G description binding site for residue ZZ7 A 301 source : AC1 11) chain A residue 220 type sequence N description binding site for residue ZZ7 A 301 source : AC1 12) chain A residue 250 type sequence H description binding site for residue ZZ7 A 301 source : AC1 13) chain B residue 34 type sequence T description binding site for residue ZZ7 A 301 source : AC1 14) chain B residue 68 type sequence P description binding site for residue ZZ7 A 301 source : AC1 15) chain B residue 69 type sequence G description binding site for residue ZZ7 A 301 source : AC1 16) chain A residue 120 type sequence H description binding site for residue ZN A 302 source : AC2 17) chain A residue 122 type sequence H description binding site for residue ZN A 302 source : AC2 18) chain A residue 189 type sequence H description binding site for residue ZN A 302 source : AC2 19) chain A residue 124 type sequence D description binding site for residue ZN A 303 source : AC3 20) chain A residue 208 type sequence C description binding site for residue ZN A 303 source : AC3 21) chain A residue 250 type sequence H description binding site for residue ZN A 303 source : AC3 22) chain A residue 120 type sequence H description binding site for residue OH A 304 source : AC4 23) chain A residue 122 type sequence H description binding site for residue OH A 304 source : AC4 24) chain A residue 124 type sequence D description binding site for residue OH A 304 source : AC4 25) chain A residue 189 type sequence H description binding site for residue OH A 304 source : AC4 26) chain A residue 208 type sequence C description binding site for residue OH A 304 source : AC4 27) chain B residue 120 type sequence H description binding site for residue ZN B 301 source : AC5 28) chain B residue 122 type sequence H description binding site for residue ZN B 301 source : AC5 29) chain B residue 189 type sequence H description binding site for residue ZN B 301 source : AC5 30) chain A residue 34 type sequence T description binding site for residue ZZ7 B 302 source : AC6 31) chain A residue 68 type sequence P description binding site for residue ZZ7 B 302 source : AC6 32) chain A residue 69 type sequence G description binding site for residue ZZ7 B 302 source : AC6 33) chain B residue 65 type sequence L description binding site for residue ZZ7 B 302 source : AC6 34) chain B residue 67 type sequence M description binding site for residue ZZ7 B 302 source : AC6 35) chain B residue 93 type sequence W description binding site for residue ZZ7 B 302 source : AC6 36) chain B residue 122 type sequence H description binding site for residue ZZ7 B 302 source : AC6 37) chain B residue 123 type sequence Q description binding site for residue ZZ7 B 302 source : AC6 38) chain B residue 124 type sequence D description binding site for residue ZZ7 B 302 source : AC6 39) chain B residue 189 type sequence H description binding site for residue ZZ7 B 302 source : AC6 40) chain B residue 208 type sequence C description binding site for residue ZZ7 B 302 source : AC6 41) chain B residue 211 type sequence K description binding site for residue ZZ7 B 302 source : AC6 42) chain B residue 219 type sequence G description binding site for residue ZZ7 B 302 source : AC6 43) chain B residue 220 type sequence N description binding site for residue ZZ7 B 302 source : AC6 44) chain B residue 250 type sequence H description binding site for residue ZZ7 B 302 source : AC6 45) chain B residue 124 type sequence D description binding site for residue ZN B 303 source : AC7 46) chain B residue 208 type sequence C description binding site for residue ZN B 303 source : AC7 47) chain B residue 250 type sequence H description binding site for residue ZN B 303 source : AC7 48) chain B residue 120 type sequence H description binding site for residue OH B 304 source : AC8 49) chain B residue 122 type sequence H description binding site for residue OH B 304 source : AC8 50) chain B residue 124 type sequence D description binding site for residue OH B 304 source : AC8 51) chain B residue 189 type sequence H description binding site for residue OH B 304 source : AC8 52) chain B residue 208 type sequence C description binding site for residue OH B 304 source : AC8 53) chain A residue 120 type BINDING sequence H description BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530 source Swiss-Prot : SWS_FT_FI1 54) chain B residue 189 type BINDING sequence H description BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530 source Swiss-Prot : SWS_FT_FI1 55) chain B residue 208 type BINDING sequence C description BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530 source Swiss-Prot : SWS_FT_FI1 56) chain B residue 250 type BINDING sequence H description BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530 source Swiss-Prot : SWS_FT_FI1 57) chain A residue 122 type BINDING sequence H description BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530 source Swiss-Prot : SWS_FT_FI1 58) chain A residue 124 type BINDING sequence D description BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530 source Swiss-Prot : SWS_FT_FI1 59) chain A residue 189 type BINDING sequence H description BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530 source Swiss-Prot : SWS_FT_FI1 60) chain A residue 208 type BINDING sequence C description BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530 source Swiss-Prot : SWS_FT_FI1 61) chain A residue 250 type BINDING sequence H description BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530 source Swiss-Prot : SWS_FT_FI1 62) chain B residue 120 type BINDING sequence H description BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530 source Swiss-Prot : SWS_FT_FI1 63) chain B residue 122 type BINDING sequence H description BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530 source Swiss-Prot : SWS_FT_FI1 64) chain B residue 124 type BINDING sequence D description BINDING => ECO:0000269|PubMed:22713171, ECO:0000269|PubMed:25815530 source Swiss-Prot : SWS_FT_FI1 65) chain A residue 211 type BINDING sequence K description BINDING => ECO:0000269|PubMed:22713171 source Swiss-Prot : SWS_FT_FI2 66) chain A residue 220 type BINDING sequence N description BINDING => ECO:0000269|PubMed:22713171 source Swiss-Prot : SWS_FT_FI2 67) chain B residue 211 type BINDING sequence K description BINDING => ECO:0000269|PubMed:22713171 source Swiss-Prot : SWS_FT_FI2 68) chain B residue 220 type BINDING sequence N description BINDING => ECO:0000269|PubMed:22713171 source Swiss-Prot : SWS_FT_FI2

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