eF-site ID 5zg2-AB PDB Code 5zg2 Chain A, B click to enlarge Title Crystal structure of the GluA2o LBD in complex with ZK200775 and Compound-2 Classification TRANSPORT PROTEIN Compound Glutamate receptor 2 Source (GRIA2_HUMAN) Sequence A:  KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEI AKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKA DIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIES AEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMR SAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR KPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNE QGLLDKLKNKWWYDKGECG B:  KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEI AKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKA DIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIES AEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMR SAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR KPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNE QGLLDKLKNKWWYDKGECG Description Functional site 1) chain A residue 423 type sequence E description binding site for residue ZK1 A 901 source : AC1 2) chain A residue 426 type sequence Y description binding site for residue ZK1 A 901 source : AC1 3) chain A residue 471 type sequence Y description binding site for residue ZK1 A 901 source : AC1 4) chain A residue 499 type sequence P description binding site for residue ZK1 A 901 source : AC1 5) chain A residue 500 type sequence L description binding site for residue ZK1 A 901 source : AC1 6) chain A residue 501 type sequence T description binding site for residue ZK1 A 901 source : AC1 7) chain A residue 506 type sequence R description binding site for residue ZK1 A 901 source : AC1 8) chain A residue 674 type sequence G description binding site for residue ZK1 A 901 source : AC1 9) chain A residue 675 type sequence S description binding site for residue ZK1 A 901 source : AC1 10) chain A residue 707 type sequence T description binding site for residue ZK1 A 901 source : AC1 11) chain A residue 726 type sequence E description binding site for residue ZK1 A 901 source : AC1 12) chain A residue 729 type sequence M description binding site for residue ZK1 A 901 source : AC1 13) chain A residue 753 type sequence Y description binding site for residue ZK1 A 901 source : AC1 14) chain A residue 502 type sequence I description binding site for residue 9C0 A 902 source : AC2 15) chain A residue 514 type sequence K description binding site for residue 9C0 A 902 source : AC2 16) chain A residue 515 type sequence P description binding site for residue 9C0 A 902 source : AC2 17) chain A residue 518 type sequence S description binding site for residue 9C0 A 902 source : AC2 18) chain A residue 750 type sequence S description binding site for residue 9C0 A 902 source : AC2 19) chain A residue 751 type sequence K description binding site for residue 9C0 A 902 source : AC2 20) chain A residue 752 type sequence G description binding site for residue 9C0 A 902 source : AC2 21) chain A residue 775 type sequence N description binding site for residue 9C0 A 902 source : AC2 22) chain B residue 502 type sequence I description binding site for residue 9C0 A 902 source : AC2 23) chain B residue 514 type sequence K description binding site for residue 9C0 A 902 source : AC2 24) chain B residue 515 type sequence P description binding site for residue 9C0 A 902 source : AC2 25) chain B residue 518 type sequence S description binding site for residue 9C0 A 902 source : AC2 26) chain B residue 750 type sequence S description binding site for residue 9C0 A 902 source : AC2 27) chain B residue 751 type sequence K description binding site for residue 9C0 A 902 source : AC2 28) chain B residue 752 type sequence G description binding site for residue 9C0 A 902 source : AC2 29) chain B residue 775 type sequence N description binding site for residue 9C0 A 902 source : AC2 30) chain A residue 452 type sequence E description binding site for residue ZN A 903 source : AC3 31) chain A residue 456 type sequence H description binding site for residue ZN A 903 source : AC3 32) chain A residue 774 type sequence L description binding site for residue ZN A 903 source : AC3 33) chain A residue 777 type sequence Q description binding site for residue ZN A 903 source : AC3 34) chain A residue 433 type sequence H description binding site for residue ZN A 904 source : AC4 35) chain A residue 470 type sequence K description binding site for residue GOL A 905 source : AC5 36) chain A residue 471 type sequence Y description binding site for residue GOL A 905 source : AC5 37) chain A residue 472 type sequence G description binding site for residue GOL A 905 source : AC5 38) chain A residue 473 type sequence A description binding site for residue GOL A 905 source : AC5 39) chain A residue 482 type sequence N description binding site for residue GOL A 905 source : AC5 40) chain B residue 423 type sequence E description binding site for residue ZK1 B 901 source : AC6 41) chain B residue 426 type sequence Y description binding site for residue ZK1 B 901 source : AC6 42) chain B residue 471 type sequence Y description binding site for residue ZK1 B 901 source : AC6 43) chain B residue 499 type sequence P description binding site for residue ZK1 B 901 source : AC6 44) chain B residue 500 type sequence L description binding site for residue ZK1 B 901 source : AC6 45) chain B residue 501 type sequence T description binding site for residue ZK1 B 901 source : AC6 46) chain B residue 506 type sequence R description binding site for residue ZK1 B 901 source : AC6 47) chain B residue 674 type sequence G description binding site for residue ZK1 B 901 source : AC6 48) chain B residue 675 type sequence S description binding site for residue ZK1 B 901 source : AC6 49) chain B residue 707 type sequence T description binding site for residue ZK1 B 901 source : AC6 50) chain B residue 726 type sequence E description binding site for residue ZK1 B 901 source : AC6 51) chain B residue 729 type sequence M description binding site for residue ZK1 B 901 source : AC6 52) chain B residue 753 type sequence Y description binding site for residue ZK1 B 901 source : AC6 53) chain B residue 437 type sequence E description binding site for residue ZN B 902 source : AC7 54) chain A residue 672 type sequence D description binding site for residue ZN B 903 source : AC8 55) chain B residue 433 type sequence H description binding site for residue ZN B 903 source : AC8 56) chain B residue 475 type sequence D description binding site for residue ZN B 904 source : AC9 57) chain A residue 441 type sequence R description binding site for residue ACT B 905 source : AD1 58) chain B residue 475 type sequence D description binding site for residue ACT B 905 source : AD1 59) chain B residue 477 type sequence D description binding site for residue ACT B 905 source : AD1 60) chain B residue 478 type sequence T description binding site for residue ACT B 905 source : AD1 61) chain B residue 474 type sequence R description binding site for residue ACT B 906 source : AD2 62) chain B residue 479 type sequence K description binding site for residue ACT B 906 source : AD2 63) chain B residue 490 type sequence Y description binding site for residue ACT B 906 source : AD2 64) chain B residue 665 type sequence E description binding site for residue ACT B 906 source : AD2 65) chain B residue 720 type sequence K description binding site for residue ACT B 906 source : AD2 66) chain A residue 672 type sequence D description binding site for residue ACT B 907 source : AD3 67) chain A residue 677 type sequence K description binding site for residue ACT B 907 source : AD3 68) chain A residue 703 type sequence F description binding site for residue ACT B 907 source : AD3 69) chain B residue 433 type sequence H description binding site for residue ACT B 907 source : AD3 70) chain B residue 470 type sequence K description binding site for residue GOL B 908 source : AD4 71) chain B residue 471 type sequence Y description binding site for residue GOL B 908 source : AD4 72) chain B residue 472 type sequence G description binding site for residue GOL B 908 source : AD4 73) chain B residue 473 type sequence A description binding site for residue GOL B 908 source : AD4 74) chain B residue 482 type sequence N description binding site for residue GOL B 908 source : AD4 75) chain A residue 499 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2 76) chain A residue 675 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI2 77) chain B residue 499 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2 78) chain B residue 675 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI2 79) chain A residue 683 type MOD_RES sequence S description Phosphoserine; by PKC => ECO:0000250|UniProtKB:P19491 source Swiss-Prot : SWS_FT_FI3 80) chain B residue 683 type MOD_RES sequence S description Phosphoserine; by PKC => ECO:0000250|UniProtKB:P19491 source Swiss-Prot : SWS_FT_FI3 81) chain A residue 717 type MOD_RES sequence S description Phosphoserine; by PKG => ECO:0000250|UniProtKB:P19491 source Swiss-Prot : SWS_FT_FI4 82) chain B residue 717 type MOD_RES sequence S description Phosphoserine; by PKG => ECO:0000250|UniProtKB:P19491 source Swiss-Prot : SWS_FT_FI4 83) chain A residue 471 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:21531559 source Swiss-Prot : SWS_FT_FI1 84) chain A residue 506 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:21531559 source Swiss-Prot : SWS_FT_FI1 85) chain A residue 726 type BINDING sequence E description BINDING => ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:21531559 source Swiss-Prot : SWS_FT_FI1 86) chain B residue 471 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:21531559 source Swiss-Prot : SWS_FT_FI1 87) chain B residue 506 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:21531559 source Swiss-Prot : SWS_FT_FI1 88) chain B residue 726 type BINDING sequence E description BINDING => ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:21531559 source Swiss-Prot : SWS_FT_FI1

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