eF-site ID 5zc9-A PDB Code 5zc9 Chain A click to enlarge Title Crystal structure of the human eIF4A1-ATP analog-RocA-polypurine RNA complex Classification TRANSLATION/RNA Compound Eukaryotic initiation factor 4A-I Source (5ZC9) Sequence A:  EIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIK GYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAP TRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQ MEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEML SRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFM RDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYE TLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQ KERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYD LPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIE TFYNTSIEEMPLNVADLI Description Functional site 1) chain A residue 52 type sequence F description binding site for residue ANP A 500 source : AC1 2) chain A residue 54 type sequence K description binding site for residue ANP A 500 source : AC1 3) chain A residue 59 type sequence Q description binding site for residue ANP A 500 source : AC1 4) chain A residue 78 type sequence S description binding site for residue ANP A 500 source : AC1 5) chain A residue 79 type sequence G description binding site for residue ANP A 500 source : AC1 6) chain A residue 80 type sequence T description binding site for residue ANP A 500 source : AC1 7) chain A residue 81 type sequence G description binding site for residue ANP A 500 source : AC1 8) chain A residue 82 type sequence K description binding site for residue ANP A 500 source : AC1 9) chain A residue 83 type sequence T description binding site for residue ANP A 500 source : AC1 10) chain A residue 183 type sequence E description binding site for residue ANP A 500 source : AC1 11) chain A residue 335 type sequence G description binding site for residue ANP A 500 source : AC1 12) chain A residue 337 type sequence D description binding site for residue ANP A 500 source : AC1 13) chain A residue 339 type sequence Q description binding site for residue ANP A 500 source : AC1 14) chain A residue 362 type sequence R description binding site for residue ANP A 500 source : AC1 15) chain A residue 365 type sequence R description binding site for residue ANP A 500 source : AC1 16) chain A residue 366 type sequence F description binding site for residue ANP A 500 source : AC1 17) chain A residue 159 type sequence P description binding site for residue RCG B 600 source : AC3 18) chain A residue 163 type sequence F description binding site for residue RCG B 600 source : AC3 19) chain A residue 195 type sequence Q description binding site for residue RCG B 600 source : AC3 20) chain A residue 198 type sequence D description binding site for residue RCG B 600 source : AC3 21) chain A residue 238 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI7 22) chain A residue 180-188 type prosite sequence VLDEADEML description DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL source prosite : PS00039 23) chain A residue 76 type BINDING sequence A description BINDING => ECO:0000255|PROSITE-ProRule:PRU00541 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 118 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 174 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 158 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 193 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P60843 source Swiss-Prot : SWS_FT_FI4 28) chain A residue 238 type MOD_RES sequence K description N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P60843 source Swiss-Prot : SWS_FT_FI5 29) chain A residue 225 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6 30) chain A residue 309 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6 31) chain A residue 369 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6 32) chain A residue 381 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6 33) chain A residue 146 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6

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