eF-site ID 5zbz-A PDB Code 5zbz Chain A click to enlarge Title Crystal structure of the DEAD domain of Human eIF4A with sanguinarine Classification HYDROLASE Compound Eukaryotic initiation factor 4A-I Source (IF4A1_HUMAN) Sequence A:  GVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEXPSAIQQ RAILPCIXGYDVIAQAQSGTGXTATFAISILQQIELDLXA TQALVLAPTRELAQQIQXVVMALGDYMGASCHACIGGTNV RAEVQXLQMEAPHIIVGTPGRVFDMLNRRYLSPXYIXMFV LDEADEMLSRGFXDQIYDIFQXLNSNTQVVLLSATMPSDV LEVTXXFMRDPIRILVXX Description Functional site 1) chain A residue 50 type sequence Y description binding site for residue SAU A 301 source : AC1 2) chain A residue 50 type sequence Y description binding site for residue SAU A 301 source : AC1 3) chain A residue 51 type sequence G description binding site for residue SAU A 301 source : AC1 4) chain A residue 52 type sequence F description binding site for residue SAU A 301 source : AC1 5) chain A residue 79 type sequence G description binding site for residue SAU A 301 source : AC1 6) chain A residue 80 type sequence T description binding site for residue SAU A 301 source : AC1 7) chain A residue 81 type sequence G description binding site for residue SAU A 301 source : AC1 8) chain A residue 115 type sequence Q description binding site for residue SAU A 301 source : AC1 9) chain A residue 78 type sequence S description binding site for residue MLI A 302 source : AC2 10) chain A residue 79 type sequence G description binding site for residue MLI A 302 source : AC2 11) chain A residue 80 type sequence T description binding site for residue MLI A 302 source : AC2 12) chain A residue 81 type sequence G description binding site for residue MLI A 302 source : AC2 13) chain A residue 82 type sequence X description binding site for residue MLI A 302 source : AC2 14) chain A residue 83 type sequence T description binding site for residue MLI A 302 source : AC2 15) chain A residue 115 type sequence Q description binding site for residue MLI A 302 source : AC2 16) chain A residue 180-188 type prosite sequence VLDEADEML description DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL source prosite : PS00039 17) chain A residue 76 type BINDING sequence A description BINDING => ECO:0000255|PROSITE-ProRule:PRU00541 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 118 type MOD_RES sequence X description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 174 type MOD_RES sequence X description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 158 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 193 type MOD_RES sequence X description N6-acetyllysine => ECO:0000250|UniProtKB:P60843 source Swiss-Prot : SWS_FT_FI4 22) chain A residue 238 type MOD_RES sequence X description N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P60843 source Swiss-Prot : SWS_FT_FI5 23) chain A residue 146 type CROSSLNK sequence X description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6 24) chain A residue 225 type CROSSLNK sequence X description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6 25) chain A residue 238 type CROSSLNK sequence X description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI7

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