eF-site ID 5z8g-A PDB Code 5z8g Chain A click to enlarge Title BRD4 Bromodomain 1 with an inhibitor Classification TRANSCRIPTION/INHIBITOR Compound Bromodomain-containing protein 4 Source (BRD4_HUMAN) Sequence A:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTEE Description Functional site 1) chain A residue 81 type sequence W description binding site for residue 99L A 201 source : AC1 2) chain A residue 82 type sequence P description binding site for residue 99L A 201 source : AC1 3) chain A residue 83 type sequence F description binding site for residue 99L A 201 source : AC1 4) chain A residue 87 type sequence V description binding site for residue 99L A 201 source : AC1 5) chain A residue 96 type sequence D description binding site for residue 99L A 201 source : AC1 6) chain A residue 97 type sequence Y description binding site for residue 99L A 201 source : AC1 7) chain A residue 139 type sequence Y description binding site for residue 99L A 201 source : AC1 8) chain A residue 140 type sequence N description binding site for residue 99L A 201 source : AC1 9) chain A residue 145 type sequence D description binding site for residue 99L A 201 source : AC1 10) chain A residue 149 type sequence M description binding site for residue 99L A 201 source : AC1 11) chain A residue 60 type sequence T description binding site for residue DMS A 202 source : AC2 12) chain A residue 62 type sequence Q description binding site for residue DMS A 202 source : AC2 13) chain A residue 121 type sequence N description binding site for residue DMS A 202 source : AC2 14) chain A residue 122 type sequence A description binding site for residue DMS A 202 source : AC2 15) chain A residue 167 type sequence E description binding site for residue DMS A 202 source : AC2 16) chain A residue 80-139 type prosite sequence AWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY WNAQECIQDFNTMFTNCYIY description BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY source prosite : PS00633 17) chain A residue 140 type SITE sequence N description Acetylated histone binding => ECO:0000269|PubMed:22464331 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 99 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI2

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