eF-site ID 5yxj-ABCD PDB Code 5yxj Chain A, B, C, D click to enlarge Title FXR ligand binding domain Classification NUCLEAR PROTEIN Compound Bile acid receptor Source (E7EWM1_HUMAN) Sequence A:  ELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEEN FLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGS AVEAMFLRSAEIFNKSGHSDLLEERIRNSGISDEYITPMF SFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHH HAEMLMSWRVNDHKFTPLLCEIWDV B:  ELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEEN FLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGS AVEAMFLRSAEIFNKHSDLLEERIRNSGISDEYITPMFSF YKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQ EPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHA EMLMSWRHKFTPLLCEIWDV C:  ENALLRYLLDK D:  ENALLRYLLDK Description Functional site 1) chain A residue 294 type sequence H description binding site for residue 93U A 501 source : AC1 2) chain A residue 328 type sequence M description binding site for residue 93U A 501 source : AC1 3) chain A residue 329 type sequence F description binding site for residue 93U A 501 source : AC1 4) chain A residue 332 type sequence S description binding site for residue 93U A 501 source : AC1 5) chain A residue 357 type sequence I description binding site for residue 93U A 501 source : AC1 6) chain A residue 362 type sequence I description binding site for residue 93U A 501 source : AC1 7) chain A residue 365 type sequence M description binding site for residue 93U A 501 source : AC1 8) chain A residue 369 type sequence Y description binding site for residue 93U A 501 source : AC1 9) chain A residue 447 type sequence H description binding site for residue 93U A 501 source : AC1 10) chain A residue 450 type sequence M description binding site for residue 93U A 501 source : AC1 11) chain A residue 451 type sequence L description binding site for residue 93U A 501 source : AC1 12) chain A residue 469 type sequence W description binding site for residue 93U A 501 source : AC1 13) chain B residue 284 type sequence F description binding site for residue 93U B 501 source : AC2 14) chain B residue 287 type sequence L description binding site for residue 93U B 501 source : AC2 15) chain B residue 290 type sequence M description binding site for residue 93U B 501 source : AC2 16) chain B residue 294 type sequence H description binding site for residue 93U B 501 source : AC2 17) chain B residue 328 type sequence M description binding site for residue 93U B 501 source : AC2 18) chain B residue 329 type sequence F description binding site for residue 93U B 501 source : AC2 19) chain B residue 332 type sequence S description binding site for residue 93U B 501 source : AC2 20) chain B residue 357 type sequence I description binding site for residue 93U B 501 source : AC2 21) chain B residue 361 type sequence Y description binding site for residue 93U B 501 source : AC2 22) chain B residue 447 type sequence H description binding site for residue 93U B 501 source : AC2 23) chain B residue 450 type sequence M description binding site for residue 93U B 501 source : AC2 24) chain B residue 454 type sequence W description binding site for residue 93U B 501 source : AC2 25) chain B residue 469 type sequence W description binding site for residue 93U B 501 source : AC2 26) chain A residue 331 type BINDING sequence R description BINDING => ECO:0007744|PDB:6HL1 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 361 type BINDING sequence Y description BINDING => ECO:0007744|PDB:6HL1 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 369 type BINDING sequence Y description BINDING => ECO:0007744|PDB:6HL1 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 447 type BINDING sequence H description BINDING => ECO:0007744|PDB:6HL1 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 331 type BINDING sequence R description BINDING => ECO:0007744|PDB:6HL1 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 361 type BINDING sequence Y description BINDING => ECO:0007744|PDB:6HL1 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 369 type BINDING sequence Y description BINDING => ECO:0007744|PDB:6HL1 source Swiss-Prot : SWS_FT_FI1 33) chain B residue 447 type BINDING sequence H description BINDING => ECO:0007744|PDB:6HL1 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 442 type MOD_RES sequence T description Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 442 type MOD_RES sequence T description Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 275 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 275 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875 source Swiss-Prot : SWS_FT_FI3

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