eF-site ID 5yxj-A
PDB Code 5yxj
Chain A

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Title FXR ligand binding domain
Classification NUCLEAR PROTEIN
Compound Bile acid receptor
Source (E7EWM1_HUMAN)
Sequence A:  ELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEEN
FLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGS
AVEAMFLRSAEIFNKSGHSDLLEERIRNSGISDEYITPMF
SFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHH
HAEMLMSWRVNDHKFTPLLCEIWDV
Description


Functional site

1) chain A
residue 294
type
sequence H
description binding site for residue 93U A 501
source : AC1

2) chain A
residue 328
type
sequence M
description binding site for residue 93U A 501
source : AC1

3) chain A
residue 329
type
sequence F
description binding site for residue 93U A 501
source : AC1

4) chain A
residue 332
type
sequence S
description binding site for residue 93U A 501
source : AC1

5) chain A
residue 357
type
sequence I
description binding site for residue 93U A 501
source : AC1

6) chain A
residue 362
type
sequence I
description binding site for residue 93U A 501
source : AC1

7) chain A
residue 365
type
sequence M
description binding site for residue 93U A 501
source : AC1

8) chain A
residue 369
type
sequence Y
description binding site for residue 93U A 501
source : AC1

9) chain A
residue 447
type
sequence H
description binding site for residue 93U A 501
source : AC1

10) chain A
residue 450
type
sequence M
description binding site for residue 93U A 501
source : AC1

11) chain A
residue 451
type
sequence L
description binding site for residue 93U A 501
source : AC1

12) chain A
residue 469
type
sequence W
description binding site for residue 93U A 501
source : AC1

13) chain A
residue 331
type BINDING
sequence R
description BINDING => ECO:0007744|PDB:6HL1
source Swiss-Prot : SWS_FT_FI1

14) chain A
residue 361
type BINDING
sequence Y
description BINDING => ECO:0007744|PDB:6HL1
source Swiss-Prot : SWS_FT_FI1

15) chain A
residue 369
type BINDING
sequence Y
description BINDING => ECO:0007744|PDB:6HL1
source Swiss-Prot : SWS_FT_FI1

16) chain A
residue 447
type BINDING
sequence H
description BINDING => ECO:0007744|PDB:6HL1
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 442
type MOD_RES
sequence T
description Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687
source Swiss-Prot : SWS_FT_FI2

18) chain A
residue 275
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875
source Swiss-Prot : SWS_FT_FI3


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