eF-site ID 5yu9-C PDB Code 5yu9 Chain C click to enlarge Title Crystal structure of EGFR 696-1022 T790M in complex with Ibrutinib Classification ONCOPROTEIN Compound Epidermal growth factor receptor Source Homo sapiens (Human) (EGFR_HUMAN) Sequence C:  EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGE KVKIPVAIKELREKANKEILDEAYVMASVDNPHVCRLLGI CLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAK LLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS KPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWM IDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSP TDSNFYRALMDEEDMVDADEYLIPQQ Description Functional site 1) chain C residue 953 type sequence I description binding site for residue CL C 1102 source : AC2 2) chain C residue 955 type sequence A description binding site for residue CL C 1102 source : AC2 3) chain C residue 726 type sequence V description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 4) chain C residue 743 type sequence A description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 5) chain C residue 766 type sequence M description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 6) chain C residue 790 type sequence M description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 7) chain C residue 791 type sequence Q description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 8) chain C residue 793 type sequence M description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 9) chain C residue 796 type sequence G description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 10) chain C residue 798 type sequence L description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 11) chain C residue 799 type sequence L description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 12) chain C residue 800 type sequence D description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 13) chain C residue 801 type sequence Y description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 14) chain C residue 841 type sequence R description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 15) chain C residue 843 type sequence V description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 16) chain C residue 854 type sequence T description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 17) chain C residue 855 type sequence D description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 18) chain C residue 856 type sequence F description binding site for Di-peptide 1E8 C 1101 and CYS C 797 source : AC5 19) chain C residue 837 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 20) chain C residue 995 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI10 21) chain C residue 998 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19563760, ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI11 22) chain C residue 1016 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19563760, ECO:0000269|PubMed:23774213 source Swiss-Prot : SWS_FT_FI12 23) chain C residue 737 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800 source Swiss-Prot : SWS_FT_FI13 24) chain C residue 754 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800 source Swiss-Prot : SWS_FT_FI13 25) chain C residue 716 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800 source Swiss-Prot : SWS_FT_FI13 26) chain C residue 929 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI14 27) chain C residue 970 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI14 28) chain C residue 757 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800 source Swiss-Prot : SWS_FT_FI15 29) chain C residue 960 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800 source Swiss-Prot : SWS_FT_FI15 30) chain C residue 718 type BINDING sequence L description BINDING => ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 source Swiss-Prot : SWS_FT_FI2 31) chain C residue 745 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 source Swiss-Prot : SWS_FT_FI3 32) chain C residue 790 type BINDING sequence M description BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 source Swiss-Prot : SWS_FT_FI4 33) chain C residue 855 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 source Swiss-Prot : SWS_FT_FI5 34) chain C residue 1016 type SITE sequence Y description Important for interaction with PIK3C2B source Swiss-Prot : SWS_FT_FI6 35) chain C residue 745 type MOD_RES sequence K description N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:29192674 source Swiss-Prot : SWS_FT_FI7 36) chain C residue 991 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:16083266, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI9

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