eF-site ID 5yqz-PR PDB Code 5yqz Chain P, R click to enlarge Title Structure of the glucagon receptor in complex with a glucagon analogue Classification SIGNALING PROTEIN/HYDROLASE Compound Glucagon receptor,Endolysin,Glucagon receptor Source null (5YQZ) Sequence P:  SQGTFTSEYSKYLDSRRAQDFVKWLLNT R:  QVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYS CWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQW VRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYT VGYSLSLGALLLALAILGGLSKLHCTANAIHANLFASFVL KASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRV AAVFMQYGIVANYCWLLVEGLYLHNLLGLATNIFEMLRID EGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAI GRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDS LDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAA VNLAKSRWYNQTPNRAKRVITTFRTGTWDAYERSFFSLYL GIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILR FPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLA KSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFL SSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWE Description Functional site 1) chain R residue 174-198 type TRANSMEM sequence NAIHANLFASFVLKASSVLVIDGLL description Helical; Name=2 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI3 2) chain R residue 199-225 type TOPO_DOM sequence RTRYSQKIGDDLSVSTWLSDGAVAGCR description Extracellular => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI4 3) chain R residue 286-303 type TOPO_DOM sequence KCLFENVQCWTSNDNMGF description Extracellular => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI4 4) chain R residue 370-381 type TOPO_DOM sequence DEHAQGTLRSAK description Extracellular => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI4 5) chain R residue 226-249 type TRANSMEM sequence VAAVFMQYGIVANYCWLLVEGLYL description Helical; Name=3 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI5 6) chain R residue 264-285 type TRANSMEM sequence FSLYLGIGWGAPMLFVVPWAVV description Helical; Name=4 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI6 7) chain R residue 304-326 type TRANSMEM sequence WWILRFPVFLAILINFFIFVRIV description Helical; Name=5 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI7 8) chain R residue 351-369 type TRANSMEM sequence TLTLIPLLGVHEVVFAFVT description Helical; Name=6 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI8 9) chain R residue 382-402 type TRANSMEM sequence LFFDLFLSSFQGLLVAVLYCF description Helical; Name=7 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI9 10) chain R residue 46 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI10 11) chain R residue 59 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI10 12) chain R residue 74 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:28514451, ECO:0007744|PDB:4ERS source Swiss-Prot : SWS_FT_FI11 13) chain R residue 78 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:28514451, ECO:0007744|PDB:4ERS source Swiss-Prot : SWS_FT_FI11 14) chain R residue 1010 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI12 15) chain R residue 1019 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI13 16) chain R residue 1031 type BINDING sequence L description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI14 17) chain R residue 1103 type BINDING sequence F description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI14 18) chain R residue 1116 type BINDING sequence S description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI15 19) chain R residue 1131 type BINDING sequence N description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI15 20) chain R residue 58-82 type prosite sequence CNRTFDKYSCWPDTPANTTANISCP description G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDkys.CWpdTpanttanisCP source prosite : PS00649 21) chain R residue 392-407 type prosite sequence QGLLVAVLYCFLNKEV description G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLLVaVLYCFlNkeV source prosite : PS00650 22) chain R residue 1010 type catalytic sequence E description 921 source MCSA : MCSA1 23) chain R residue 1019 type catalytic sequence D description 921 source MCSA : MCSA1 24) chain P residue 2 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P55095 source Swiss-Prot : SWS_FT_FI1 25) chain R residue 162-173 type TOPO_DOM sequence ILGGLSKLHCTA description Cytoplasmic => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI2 26) chain R residue 327-350 type TOPO_DOM sequence QLLVAKLRARQMHHTDYKFRLAKS description Cytoplasmic => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 source Swiss-Prot : SWS_FT_FI2

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