eF-site ID 5ypr-A
PDB Code 5ypr
Chain A

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Title Crystal Structure of PSD-95 SH3-GK domain in complex with a synthesized inhibitor
Classification PROTEIN BINDING
Compound Disks large homolog 4
Source Rattus norvegicus (Rat) (5YPR)
Sequence A:  RGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDAGDE
EWWQARRVHDIGFIPSKRRVERRESVLSYETVTQMEVHYA
RPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYE
IDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQ
SVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRS
LENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEG
DSFEEIYHKVKRVIEDLSGPYIWVPAR
Description


Functional site
1) chain A
residue 566-583
type prosite
sequence TTRPKREYEIDGRDYHFV
description GUANYLATE_KINASE_1 Guanylate kinase-like signature. TTRpkReyEidGrdYhFV
source prosite : PS00856
2) chain A
residue 449
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1
3) chain A
residue 654
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1
4) chain A
residue 606
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:Q62108
source Swiss-Prot : SWS_FT_FI2
5) chain A
residue 580
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0000250|UniProtKB:Q62108
source Swiss-Prot : SWS_FT_FI3
6) chain A
residue 715
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0000250|UniProtKB:Q62108
source Swiss-Prot : SWS_FT_FI3

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