eF-site/Summary 5xf1-B

eF-site ID	5xf1-B
PDB Code	5xf1
Chain	B

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Title	Structure of the Full-length glucagon class B G protein-coupled receptor
Classification	SIGNALING PROTEIN
Compound	Glucagon receptor,Endolysin,Glucagon receptor
Source	(5XF1)

Sequence	B:	GAPQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFD KYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPD GQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQV MYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFAS FVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAG CRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLANIFEMLR IDELFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINM VFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQT PNRAKRVITTFRTGTWDAYERSFFSLYLGIGWGAPMLFVV PWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFF IFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLY CFLNKEVQSELRRRWH

Description

Functional site


1)	chain	B
	residue	1011
	type	catalytic
	sequence	E
	description	921
	source	MCSA : MCSA2

2)	chain	B
	residue	174-198
	type	TRANSMEM
	sequence	NAIHANLFASFVLKASSVLVIDGLL
	description	Helical; Name=2 => ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI3

3)	chain	B
	residue	46
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI10

4)	chain	B
	residue	59
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI10

5)	chain	B
	residue	74
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:22908259, ECO:0000269\|PubMed:28514451, ECO:0007744\|PDB:4ERS
	source	Swiss-Prot : SWS_FT_FI11

6)	chain	B
	residue	78
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:22908259, ECO:0000269\|PubMed:28514451, ECO:0007744\|PDB:4ERS
	source	Swiss-Prot : SWS_FT_FI11

7)	chain	B
	residue	1011
	type	ACT_SITE
	sequence	E
	description	Proton donor/acceptor => ECO:0000255\|HAMAP-Rule:MF_04110, ECO:0000269\|PubMed:3382407, ECO:0000269\|PubMed:7831309, ECO:0000269\|PubMed:8266098
	source	Swiss-Prot : SWS_FT_FI12

8)	chain	B
	residue	199-225
	type	TOPO_DOM
	sequence	RTRYSQKIGDDLSVSTWLSDGAVAGCR
	description	Extracellular => ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI4

9)	chain	B
	residue	286-303
	type	TOPO_DOM
	sequence	KCLFENVQCWTSNDNMGF
	description	Extracellular => ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI4

10)	chain	B
	residue	370-381
	type	TOPO_DOM
	sequence	DEHAQGTLRSAK
	description	Extracellular => ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI4

11)	chain	B
	residue	226-249
	type	TRANSMEM
	sequence	VAAVFMQYGIVANYCWLLVEGLYL
	description	Helical; Name=3 => ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI5

12)	chain	B
	residue	264-285
	type	TRANSMEM
	sequence	FSLYLGIGWGAPMLFVVPWAVV
	description	Helical; Name=4 => ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI6

13)	chain	B
	residue	304-326
	type	TRANSMEM
	sequence	WWILRFPVFLAILINFFIFVRIV
	description	Helical; Name=5 => ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI7

14)	chain	B
	residue	351-369
	type	TRANSMEM
	sequence	TLTLIPLLGVHEVVFAFVT
	description	Helical; Name=6 => ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI8

15)	chain	B
	residue	382-402
	type	TRANSMEM
	sequence	LFFDLFLSSFQGLLVAVLYCF
	description	Helical; Name=7 => ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI9

16)	chain	B
	residue	137-161
	type	TRANSMEM
	sequence	MYSSFQVMYTVGYSLSLGALLLALA
	description	Helical; Name=1 => ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI1

17)	chain	B
	residue	1104
	type	BINDING
	sequence	F
	description	BINDING => ECO:0000269\|PubMed:8266098
	source	Swiss-Prot : SWS_FT_FI14

18)	chain	B
	residue	1117
	type	BINDING
	sequence	S
	description	BINDING => ECO:0000303\|PubMed:7831309
	source	Swiss-Prot : SWS_FT_FI15

19)	chain	B
	residue	1132
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000303\|PubMed:7831309
	source	Swiss-Prot : SWS_FT_FI15

20)	chain	B
	residue	162-173
	type	TOPO_DOM
	sequence	ILGGLSKLHCTR
	description	Cytoplasmic => ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI2

21)	chain	B
	residue	327-350
	type	TOPO_DOM
	sequence	QLLVAKLRARQMHHTDYKFRLAKS
	description	Cytoplasmic => ECO:0000269\|PubMed:23863937, ECO:0000269\|PubMed:27111510, ECO:0000269\|PubMed:28514451
	source	Swiss-Prot : SWS_FT_FI2