eF-site ID 5xez-ABCDHL
PDB Code 5xez
Chain A, B, C, D, H, L

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Title Structure of the Full-length glucagon class B G protein-coupled receptor
Classification SIGNALING PROTEIN
Compound Glucagon receptor,Endolysin,Glucagon receptor
Source (5XEZ)
Sequence A:  QVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYS
CWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQW
VRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYT
VGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVL
KASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRV
AAVFMQYGIVANYCWLLVEGLYLHNLLGLANIFEMLRIDE
GLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIG
RNITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVR
RAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAK
SRWYNQTPNRAKRVITTFRTGTWDAYERSFFSLYLGIGWG
APMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFL
AILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLT
LIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQG
LLVAVLYCFLNKEVQSELRRRWHRW
B:  GAPQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFD
KYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPD
GQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQV
MYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFAS
FVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAG
CRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLANIFEMLR
IDELFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINM
VFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQT
PNRAKRVITTFRTGTWDAYERSFFSLYLGIGWGAPMLFVV
PWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFF
IFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLY
CFLNKEVQSELRRRWHRWR
C:  QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQA
PGKGLEWVAVMYYDGSNKDYVDSVKGRFTISRDNSKNTLY
LQMNRLRAEDTAVYYCAREKDHYDILTGYNYYYGLDVWGQ
GTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDY
FPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP
SSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
D:  DIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKP
GKAPKRLIYAASSLESGVPSRFSGSGSGTEFTLTISSVQP
EDFVTYYCLQHNSNPLTFGGGTKVEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG
LSSPVTKSFNRGEC
H:  QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQA
PGKGLEWVAVMYYDGSNKDYVDSVKGRFTISRDNSKNTLY
LQMNRLRAEDTAVYYCAREKDHYDILTGYNYYYGLDVWGQ
GTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDY
FPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP
SSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
L:  DIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKP
GKAPKRLIYAASSLESGVPSRFSGSGSGTEFTLTISSVQP
EDFVTYYCLQHNSNPLTFGGGTKVEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG
LSSPVTKSFNRGEC
Description


Functional site
1) chain A
residue 1011
type catalytic
sequence E
description 921
source MCSA : MCSA1
2) chain A
residue 1020
type catalytic
sequence D
description 921
source MCSA : MCSA1
3) chain B
residue 1011
type catalytic
sequence E
description 921
source MCSA : MCSA2
4) chain A
residue 137-161
type TRANSMEM
sequence MYSSFQVMYTVGYSLSLGALLLALA
description Helical; Name=1 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI1
5) chain B
residue 137-161
type TRANSMEM
sequence MYSSFQVMYTVGYSLSLGALLLALA
description Helical; Name=1 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI1
6) chain A
residue 46
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI10
7) chain A
residue 59
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI10
8) chain B
residue 46
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI10
9) chain B
residue 59
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI10
10) chain A
residue 74
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:28514451, ECO:0007744|PDB:4ERS
source Swiss-Prot : SWS_FT_FI11
11) chain A
residue 78
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:28514451, ECO:0007744|PDB:4ERS
source Swiss-Prot : SWS_FT_FI11
12) chain B
residue 74
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:28514451, ECO:0007744|PDB:4ERS
source Swiss-Prot : SWS_FT_FI11
13) chain B
residue 78
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:28514451, ECO:0007744|PDB:4ERS
source Swiss-Prot : SWS_FT_FI11
14) chain A
residue 1011
type ACT_SITE
sequence E
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098
source Swiss-Prot : SWS_FT_FI12
15) chain B
residue 1011
type ACT_SITE
sequence E
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098
source Swiss-Prot : SWS_FT_FI12
16) chain A
residue 174-198
type TRANSMEM
sequence NAIHANLFASFVLKASSVLVIDGLL
description Helical; Name=2 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI3
17) chain B
residue 174-198
type TRANSMEM
sequence NAIHANLFASFVLKASSVLVIDGLL
description Helical; Name=2 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI3
18) chain A
residue 199-225
type TOPO_DOM
sequence RTRYSQKIGDDLSVSTWLSDGAVAGCR
description Extracellular => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI4
19) chain A
residue 286-303
type TOPO_DOM
sequence KCLFENVQCWTSNDNMGF
description Extracellular => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI4
20) chain A
residue 370-381
type TOPO_DOM
sequence DEHAQGTLRSAK
description Extracellular => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI4
21) chain B
residue 199-225
type TOPO_DOM
sequence RTRYSQKIGDDLSVSTWLSDGAVAGCR
description Extracellular => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI4
22) chain B
residue 286-303
type TOPO_DOM
sequence KCLFENVQCWTSNDNMGF
description Extracellular => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI4
23) chain B
residue 370-381
type TOPO_DOM
sequence DEHAQGTLRSAK
description Extracellular => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI4
24) chain A
residue 226-249
type TRANSMEM
sequence VAAVFMQYGIVANYCWLLVEGLYL
description Helical; Name=3 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI5
25) chain B
residue 226-249
type TRANSMEM
sequence VAAVFMQYGIVANYCWLLVEGLYL
description Helical; Name=3 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI5
26) chain A
residue 264-285
type TRANSMEM
sequence FSLYLGIGWGAPMLFVVPWAVV
description Helical; Name=4 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI6
27) chain B
residue 264-285
type TRANSMEM
sequence FSLYLGIGWGAPMLFVVPWAVV
description Helical; Name=4 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI6
28) chain A
residue 304-326
type TRANSMEM
sequence WWILRFPVFLAILINFFIFVRIV
description Helical; Name=5 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI7
29) chain B
residue 304-326
type TRANSMEM
sequence WWILRFPVFLAILINFFIFVRIV
description Helical; Name=5 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI7
30) chain A
residue 351-369
type TRANSMEM
sequence TLTLIPLLGVHEVVFAFVT
description Helical; Name=6 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI8
31) chain B
residue 351-369
type TRANSMEM
sequence TLTLIPLLGVHEVVFAFVT
description Helical; Name=6 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI8
32) chain A
residue 382-402
type TRANSMEM
sequence LFFDLFLSSFQGLLVAVLYCF
description Helical; Name=7 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI9
33) chain B
residue 382-402
type TRANSMEM
sequence LFFDLFLSSFQGLLVAVLYCF
description Helical; Name=7 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI9
34) chain A
residue 162-173
type TOPO_DOM
sequence ILGGLSKLHCTR
description Cytoplasmic => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI2
35) chain A
residue 327-350
type TOPO_DOM
sequence QLLVAKLRARQMHHTDYKFRLAKS
description Cytoplasmic => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI2
36) chain B
residue 162-173
type TOPO_DOM
sequence ILGGLSKLHCTR
description Cytoplasmic => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI2
37) chain B
residue 327-350
type TOPO_DOM
sequence QLLVAKLRARQMHHTDYKFRLAKS
description Cytoplasmic => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI2
38) chain A
residue 1020
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098
source Swiss-Prot : SWS_FT_FI13
39) chain A
residue 1032
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:8266098
source Swiss-Prot : SWS_FT_FI14
40) chain A
residue 1104
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:8266098
source Swiss-Prot : SWS_FT_FI14
41) chain B
residue 1104
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:8266098
source Swiss-Prot : SWS_FT_FI14
42) chain A
residue 1117
type BINDING
sequence S
description BINDING => ECO:0000303|PubMed:7831309
source Swiss-Prot : SWS_FT_FI15
43) chain A
residue 1132
type BINDING
sequence N
description BINDING => ECO:0000303|PubMed:7831309
source Swiss-Prot : SWS_FT_FI15
44) chain B
residue 1117
type BINDING
sequence S
description BINDING => ECO:0000303|PubMed:7831309
source Swiss-Prot : SWS_FT_FI15
45) chain B
residue 1132
type BINDING
sequence N
description BINDING => ECO:0000303|PubMed:7831309
source Swiss-Prot : SWS_FT_FI15
46) chain A
residue 58-82
type prosite
sequence CNRTFDKYSCWPDTPANTTANISCP
description G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDkys.CWpdTpanttanisCP
source prosite : PS00649
47) chain A
residue 392-407
type prosite
sequence QGLLVAVLYCFLNKEV
description G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLLVaVLYCFlNkeV
source prosite : PS00650
48) chain D
residue 192-198
type prosite
sequence YACEVTH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
source prosite : PS00290
49) chain C
residue 423-429
type prosite
sequence YICNVNH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
source prosite : PS00290

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