eF-site ID 5xez-A
PDB Code 5xez
Chain A

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Title Structure of the Full-length glucagon class B G protein-coupled receptor
Classification SIGNALING PROTEIN
Compound Glucagon receptor,Endolysin,Glucagon receptor
Source (5XEZ)
Sequence A:  QVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYS
CWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQW
VRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYT
VGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVL
KASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRV
AAVFMQYGIVANYCWLLVEGLYLHNLLGLANIFEMLRIDE
GLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIG
RNITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVR
RAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAK
SRWYNQTPNRAKRVITTFRTGTWDAYERSFFSLYLGIGWG
APMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFL
AILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLT
LIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQG
LLVAVLYCFLNKEVQSELRRRWHRW
Description


Functional site
1) chain A
residue 1020
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098
source Swiss-Prot : SWS_FT_FI13
2) chain A
residue 1032
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:8266098
source Swiss-Prot : SWS_FT_FI14
3) chain A
residue 1104
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:8266098
source Swiss-Prot : SWS_FT_FI14
4) chain A
residue 1117
type BINDING
sequence S
description BINDING => ECO:0000303|PubMed:7831309
source Swiss-Prot : SWS_FT_FI15
5) chain A
residue 1132
type BINDING
sequence N
description BINDING => ECO:0000303|PubMed:7831309
source Swiss-Prot : SWS_FT_FI15
6) chain A
residue 58-82
type prosite
sequence CNRTFDKYSCWPDTPANTTANISCP
description G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDkys.CWpdTpanttanisCP
source prosite : PS00649
7) chain A
residue 392-407
type prosite
sequence QGLLVAVLYCFLNKEV
description G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLLVaVLYCFlNkeV
source prosite : PS00650
8) chain A
residue 1011
type catalytic
sequence E
description 921
source MCSA : MCSA1
9) chain A
residue 1020
type catalytic
sequence D
description 921
source MCSA : MCSA1
10) chain A
residue 137-161
type TRANSMEM
sequence MYSSFQVMYTVGYSLSLGALLLALA
description Helical; Name=1 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI1
11) chain A
residue 162-173
type TOPO_DOM
sequence ILGGLSKLHCTR
description Cytoplasmic => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI2
12) chain A
residue 327-350
type TOPO_DOM
sequence QLLVAKLRARQMHHTDYKFRLAKS
description Cytoplasmic => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI2
13) chain A
residue 174-198
type TRANSMEM
sequence NAIHANLFASFVLKASSVLVIDGLL
description Helical; Name=2 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI3
14) chain A
residue 199-225
type TOPO_DOM
sequence RTRYSQKIGDDLSVSTWLSDGAVAGCR
description Extracellular => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI4
15) chain A
residue 286-303
type TOPO_DOM
sequence KCLFENVQCWTSNDNMGF
description Extracellular => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI4
16) chain A
residue 370-381
type TOPO_DOM
sequence DEHAQGTLRSAK
description Extracellular => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI4
17) chain A
residue 226-249
type TRANSMEM
sequence VAAVFMQYGIVANYCWLLVEGLYL
description Helical; Name=3 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI5
18) chain A
residue 264-285
type TRANSMEM
sequence FSLYLGIGWGAPMLFVVPWAVV
description Helical; Name=4 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI6
19) chain A
residue 304-326
type TRANSMEM
sequence WWILRFPVFLAILINFFIFVRIV
description Helical; Name=5 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI7
20) chain A
residue 351-369
type TRANSMEM
sequence TLTLIPLLGVHEVVFAFVT
description Helical; Name=6 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI8
21) chain A
residue 382-402
type TRANSMEM
sequence LFFDLFLSSFQGLLVAVLYCF
description Helical; Name=7 => ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI9
22) chain A
residue 46
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI10
23) chain A
residue 59
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28514451
source Swiss-Prot : SWS_FT_FI10
24) chain A
residue 74
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:28514451, ECO:0007744|PDB:4ERS
source Swiss-Prot : SWS_FT_FI11
25) chain A
residue 78
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:28514451, ECO:0007744|PDB:4ERS
source Swiss-Prot : SWS_FT_FI11
26) chain A
residue 1011
type ACT_SITE
sequence E
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098
source Swiss-Prot : SWS_FT_FI12

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