eF-site ID 5xb3-AB PDB Code 5xb3 Chain A, B click to enlarge Title ADP-dTMP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 Classification TRANSFERASE Compound Thymidylate kinase Source Aquifex aeolicus (strain VF5) (KTHY_AQUAE) Sequence A:  MLIAFEGIDGSGKTTQAKKLYEYLKQKGYFVSLYREPGGT KVGEVLREILLTEELDERTELLLFEASRSKLIEEKIIPDL KRDKVVILDRFVLSTIAYQGYGKGLDVEFIKNLNEFATRG VKPDITLLLDIPVDIALRRLKEKNRFENKEFLEKVRKGFL ELAKEEENVVVIDASGEEEEVFKEILRALSGVL B:  MLIAFEGIDGSGKTTQAKKLYEYLKQKGYFVSLYREPGGT KVGEVLREILLTEELDERTELLLFEASRSKLIEEKIIPDL KRDKVVILDRFVLSTIAYQGYGKGLDVEFIKNLNEFATRG VKPDITLLLDIPVDIALRRLKEKNRFENKEFLEKVRKGFL ELAKEEENVVVIDASGEEEEVFKEILRALSGVLR Description Functional site 1) chain A residue 10 type sequence G description binding site for residue ADP A 201 source : AC1 2) chain A residue 11 type sequence S description binding site for residue ADP A 201 source : AC1 3) chain A residue 12 type sequence G description binding site for residue ADP A 201 source : AC1 4) chain A residue 13 type sequence K description binding site for residue ADP A 201 source : AC1 5) chain A residue 14 type sequence T description binding site for residue ADP A 201 source : AC1 6) chain A residue 15 type sequence T description binding site for residue ADP A 201 source : AC1 7) chain A residue 139 type sequence R description binding site for residue ADP A 201 source : AC1 8) chain A residue 145 type sequence R description binding site for residue ADP A 201 source : AC1 9) chain A residue 176 type sequence G description binding site for residue ADP A 201 source : AC1 10) chain A residue 177 type sequence E description binding site for residue ADP A 201 source : AC1 11) chain A residue 178 type sequence E description binding site for residue ADP A 201 source : AC1 12) chain A residue 9 type sequence D description binding site for residue TMP A 202 source : AC2 13) chain A residue 36 type sequence E description binding site for residue TMP A 202 source : AC2 14) chain A residue 47 type sequence R description binding site for residue TMP A 202 source : AC2 15) chain A residue 64 type sequence F description binding site for residue TMP A 202 source : AC2 16) chain A residue 90 type sequence R description binding site for residue TMP A 202 source : AC2 17) chain A residue 95 type sequence T description binding site for residue TMP A 202 source : AC2 18) chain A residue 98 type sequence Y description binding site for residue TMP A 202 source : AC2 19) chain A residue 99 type sequence Q description binding site for residue TMP A 202 source : AC2 20) chain B residue 10 type sequence G description binding site for residue ADP B 201 source : AC3 21) chain B residue 11 type sequence S description binding site for residue ADP B 201 source : AC3 22) chain B residue 12 type sequence G description binding site for residue ADP B 201 source : AC3 23) chain B residue 13 type sequence K description binding site for residue ADP B 201 source : AC3 24) chain B residue 14 type sequence T description binding site for residue ADP B 201 source : AC3 25) chain B residue 15 type sequence T description binding site for residue ADP B 201 source : AC3 26) chain B residue 139 type sequence R description binding site for residue ADP B 201 source : AC3 27) chain B residue 143 type sequence K description binding site for residue ADP B 201 source : AC3 28) chain B residue 145 type sequence R description binding site for residue ADP B 201 source : AC3 29) chain B residue 176 type sequence G description binding site for residue ADP B 201 source : AC3 30) chain B residue 177 type sequence E description binding site for residue ADP B 201 source : AC3 31) chain B residue 178 type sequence E description binding site for residue ADP B 201 source : AC3 32) chain B residue 9 type sequence D description binding site for residue TMP B 202 source : AC4 33) chain B residue 36 type sequence E description binding site for residue TMP B 202 source : AC4 34) chain B residue 47 type sequence R description binding site for residue TMP B 202 source : AC4 35) chain B residue 64 type sequence F description binding site for residue TMP B 202 source : AC4 36) chain B residue 90 type sequence R description binding site for residue TMP B 202 source : AC4 37) chain B residue 95 type sequence T description binding site for residue TMP B 202 source : AC4 38) chain B residue 98 type sequence Y description binding site for residue TMP B 202 source : AC4 39) chain B residue 99 type sequence Q description binding site for residue TMP B 202 source : AC4 40) chain B residue 145 type sequence R description binding site for residue TMP B 202 source : AC4 41) chain A residue 87-99 type prosite sequence ILDRFVLSTIAYQ description THYMIDYLATE_KINASE Thymidylate kinase signature. ILDRFvlSTiAYQ source prosite : PS01331 42) chain A residue 7 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 7 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1

Display surface Download Links