eF-site ID 5xb2-AB PDB Code 5xb2 Chain A, B click to enlarge Title ADP-Mg-F-dTMP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 Classification TRANSFERASE Compound Thymidylate kinase Source Aquifex aeolicus (strain VF5) (KTHY_AQUAE) Sequence A:  MLIAFEGIDGSGKTTQAKKLYEYLKQKGYFVSLYREPGGT KVGEVLREILLTEELDERTELLLFEASRSKLIEEKIIPDL KRDKVVILDRFVLSTIAYQGYGKGLDVEFIKNLNEFATRG VKPDITLLLDIPVDIALRRLKEKNRFENKEFLEKVRKGFL ELAKEEENVVVIDASGEEEEVFKEILRALSGVLR B:  MLIAFEGIDGSGKTTQAKKLYEYLKQKGYFVSLYREPGGT KVGEVLREILLTEELDERTELLLFEASRSKLIEEKIIPDL KRDKVVILDRFVLSTIAYQGYGKGLDVEFIKNLNEFATRG VKPDITLLLDIPVDIALRRLKEKNRFENKEFLEKVRKGFL ELAKEEENVVVIDASGEEEEVFKEILRALSGVLR Description Functional site 1) chain B residue 10 type sequence G description binding site for residue ADP B 201 source : AC1 2) chain B residue 11 type sequence S description binding site for residue ADP B 201 source : AC1 3) chain B residue 12 type sequence G description binding site for residue ADP B 201 source : AC1 4) chain B residue 13 type sequence K description binding site for residue ADP B 201 source : AC1 5) chain B residue 14 type sequence T description binding site for residue ADP B 201 source : AC1 6) chain B residue 15 type sequence T description binding site for residue ADP B 201 source : AC1 7) chain B residue 139 type sequence R description binding site for residue ADP B 201 source : AC1 8) chain B residue 145 type sequence R description binding site for residue ADP B 201 source : AC1 9) chain B residue 176 type sequence G description binding site for residue ADP B 201 source : AC1 10) chain B residue 177 type sequence E description binding site for residue ADP B 201 source : AC1 11) chain B residue 178 type sequence E description binding site for residue ADP B 201 source : AC1 12) chain B residue 9 type sequence D description binding site for residue TMP B 202 source : AC2 13) chain B residue 36 type sequence E description binding site for residue TMP B 202 source : AC2 14) chain B residue 47 type sequence R description binding site for residue TMP B 202 source : AC2 15) chain B residue 64 type sequence F description binding site for residue TMP B 202 source : AC2 16) chain B residue 68 type sequence R description binding site for residue TMP B 202 source : AC2 17) chain B residue 90 type sequence R description binding site for residue TMP B 202 source : AC2 18) chain B residue 95 type sequence T description binding site for residue TMP B 202 source : AC2 19) chain B residue 98 type sequence Y description binding site for residue TMP B 202 source : AC2 20) chain B residue 99 type sequence Q description binding site for residue TMP B 202 source : AC2 21) chain B residue 145 type sequence R description binding site for residue TMP B 202 source : AC2 22) chain B residue 14 type sequence T description binding site for residue MG B 203 source : AC3 23) chain B residue 89 type sequence D description binding site for residue MG B 203 source : AC3 24) chain B residue 13 type sequence K description binding site for residue F B 204 source : AC4 25) chain B residue 14 type sequence T description binding site for residue F B 204 source : AC4 26) chain B residue 89 type sequence D description binding site for residue F B 204 source : AC4 27) chain B residue 14 type sequence T description binding site for residue F B 205 source : AC5 28) chain B residue 145 type sequence R description binding site for residue F B 205 source : AC5 29) chain B residue 14 type sequence T description binding site for residue F B 206 source : AC6 30) chain B residue 89 type sequence D description binding site for residue F B 206 source : AC6 31) chain A residue 10 type sequence G description binding site for residue ADP A 201 source : AC7 32) chain A residue 11 type sequence S description binding site for residue ADP A 201 source : AC7 33) chain A residue 12 type sequence G description binding site for residue ADP A 201 source : AC7 34) chain A residue 13 type sequence K description binding site for residue ADP A 201 source : AC7 35) chain A residue 14 type sequence T description binding site for residue ADP A 201 source : AC7 36) chain A residue 15 type sequence T description binding site for residue ADP A 201 source : AC7 37) chain A residue 139 type sequence R description binding site for residue ADP A 201 source : AC7 38) chain A residue 143 type sequence K description binding site for residue ADP A 201 source : AC7 39) chain A residue 145 type sequence R description binding site for residue ADP A 201 source : AC7 40) chain A residue 176 type sequence G description binding site for residue ADP A 201 source : AC7 41) chain A residue 177 type sequence E description binding site for residue ADP A 201 source : AC7 42) chain A residue 178 type sequence E description binding site for residue ADP A 201 source : AC7 43) chain A residue 9 type sequence D description binding site for residue TMP A 202 source : AC8 44) chain A residue 36 type sequence E description binding site for residue TMP A 202 source : AC8 45) chain A residue 47 type sequence R description binding site for residue TMP A 202 source : AC8 46) chain A residue 64 type sequence F description binding site for residue TMP A 202 source : AC8 47) chain A residue 68 type sequence R description binding site for residue TMP A 202 source : AC8 48) chain A residue 90 type sequence R description binding site for residue TMP A 202 source : AC8 49) chain A residue 95 type sequence T description binding site for residue TMP A 202 source : AC8 50) chain A residue 98 type sequence Y description binding site for residue TMP A 202 source : AC8 51) chain A residue 99 type sequence Q description binding site for residue TMP A 202 source : AC8 52) chain A residue 145 type sequence R description binding site for residue TMP A 202 source : AC8 53) chain B residue 7 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 54) chain A residue 7 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 55) chain B residue 87-99 type prosite sequence ILDRFVLSTIAYQ description THYMIDYLATE_KINASE Thymidylate kinase signature. ILDRFvlSTiAYQ source prosite : PS01331

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