eF-site ID 5xai-AB PDB Code 5xai Chain A, B click to enlarge Title dTMP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 Classification TRANSFERASE Compound Thymidylate kinase Source Aquifex aeolicus (strain VF5) (KTHY_AQUAE) Sequence A:  MLIAFEGIDGSGKTTQAKKLYEYLKQKGYFVSLYREPGGT KVGEVLREILLTEELDERTELLLFEASRSKLIEEKIIPDL KRDKVVILDRFVLSTIAYQGYGKGLDVEFIKNLNEFATRG VKPDITLLLDIPVDIALRRLKEKNRFENKEFLEKVRKGFL ELAKEEENVVVIDASGEEEEVFKEILRALSGVLR B:  MLIAFEGIDGSGKTTQAKKLYEYLKQKGYFVSLYREPGGT KVGEVLREILLTEELDERTELLLFEASRSKLIEEKIIPDL KRDKVVILDRFVLSTIAYQGYGKGLDVEFIKNLNEFATRG VKPDITLLLDIPVDIALRRLKEKNRFENKEFLEKVRKGFL ELAKEEENVVVIDASGEEEEVFKEILRALSGV Description Functional site 1) chain B residue 10 type sequence G description binding site for residue PO4 B 201 source : AC1 2) chain B residue 11 type sequence S description binding site for residue PO4 B 201 source : AC1 3) chain B residue 12 type sequence G description binding site for residue PO4 B 201 source : AC1 4) chain B residue 13 type sequence K description binding site for residue PO4 B 201 source : AC1 5) chain B residue 14 type sequence T description binding site for residue PO4 B 201 source : AC1 6) chain B residue 9 type sequence D description binding site for residue TMP B 202 source : AC2 7) chain B residue 13 type sequence K description binding site for residue TMP B 202 source : AC2 8) chain B residue 36 type sequence E description binding site for residue TMP B 202 source : AC2 9) chain B residue 47 type sequence R description binding site for residue TMP B 202 source : AC2 10) chain B residue 64 type sequence F description binding site for residue TMP B 202 source : AC2 11) chain B residue 90 type sequence R description binding site for residue TMP B 202 source : AC2 12) chain B residue 95 type sequence T description binding site for residue TMP B 202 source : AC2 13) chain B residue 98 type sequence Y description binding site for residue TMP B 202 source : AC2 14) chain B residue 99 type sequence Q description binding site for residue TMP B 202 source : AC2 15) chain A residue 10 type sequence G description binding site for residue PO4 A 201 source : AC3 16) chain A residue 11 type sequence S description binding site for residue PO4 A 201 source : AC3 17) chain A residue 12 type sequence G description binding site for residue PO4 A 201 source : AC3 18) chain A residue 13 type sequence K description binding site for residue PO4 A 201 source : AC3 19) chain A residue 14 type sequence T description binding site for residue PO4 A 201 source : AC3 20) chain A residue 9 type sequence D description binding site for residue TMP A 202 source : AC4 21) chain A residue 13 type sequence K description binding site for residue TMP A 202 source : AC4 22) chain A residue 36 type sequence E description binding site for residue TMP A 202 source : AC4 23) chain A residue 47 type sequence R description binding site for residue TMP A 202 source : AC4 24) chain A residue 64 type sequence F description binding site for residue TMP A 202 source : AC4 25) chain A residue 90 type sequence R description binding site for residue TMP A 202 source : AC4 26) chain A residue 95 type sequence T description binding site for residue TMP A 202 source : AC4 27) chain A residue 98 type sequence Y description binding site for residue TMP A 202 source : AC4 28) chain A residue 99 type sequence Q description binding site for residue TMP A 202 source : AC4 29) chain B residue 87-99 type prosite sequence ILDRFVLSTIAYQ description THYMIDYLATE_KINASE Thymidylate kinase signature. ILDRFvlSTiAYQ source prosite : PS01331 30) chain B residue 7 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 7 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1

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