eF-site ID 5x21-F PDB Code 5x21 Chain F click to enlarge Title Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) Classification TRANSFERASE/DNA Compound DNA-directed RNA polymerase subunit alpha Source ORGANISM_SCIENTIFIC: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579); Sequence F:  SDPVRQYLHEIGQVPLLTLEEEVELARKVEEGMEAIKKLS EITGLDPDLIREVVRAKILGSARVRHIPGLKETLDPKTVE EIDQKLKSLPKEHKRYLHIAREGEAARQHLIEANLRLVVS IAKKYTGRGLSFLDLIQEGNQGLIRAVEKFEYKRRFKFST YATWWIRQAINRAIADQARTIRIPVHMVETINKLSRTARQ LQQELGREPTYEEIAEAMGPGWDAKRVEETLKIAQEPVSL ETPIGDEKDSFYGDFIPDEHLPSPVDAATQSLLSEELEKA LSKLSEREAMVLKLRKGLIDGREHTLEEVGAFFGVTRERI RQIENKALRKLKYHESRTRKLRDFLD Description Functional site 1) chain F residue 292 type sequence A description binding site for residue MG F 2001 source : AC7 2) chain F residue 296 type sequence G description binding site for residue MG F 2001 source : AC7 3) chain F residue 299 type sequence W description binding site for residue MG F 2001 source : AC7 4) chain F residue 382-408 type prosite sequence TLEEVGAFFGVTRERIRQIENKALRKL description SIGMA70_2 Sigma-70 factors family signature 2. TleEVGaffgVTrerIrQIEnkaLrkL source prosite : PS00716 5) chain F residue 187-194 type prosite sequence LIEANLRL description CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LIEANLRL source prosite : PS00867 6) chain F residue 383-402 type DNA_BIND sequence LEEVGAFFGVTRERIRQIEN description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1

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