eF-site ID 5x21-D PDB Code 5x21 Chain D click to enlarge Title Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) Classification TRANSFERASE/DNA Compound DNA-directed RNA polymerase subunit alpha Source ORGANISM_SCIENTIFIC: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579); Sequence D:  KEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERD GLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVTK SIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSATE LEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYRELR YGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDGV ALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEIL AELPEPYLFRAEEEGVVELKELEEGAFLVLRREDEPVATY FLPVGMTPLVVHGEIVEKGQPLAEAKGLLRMPRQVRAAQV EAEEEGETVYLTLFLEWTEPKDYRVQPHMNVVVPEGARVE AGDKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYP FEDDVEVSTGDRVAPGDVLADGGKVKSDVYGRVEVDLVRN VVRVVESYDIDARMGAEAIQQLLKELDLEALEKELLEEMK HPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPP DLRPMVQVDGGRFATSDLNDLYRRLINRNNRLKKLLAQGA PEIIIRNEKRMLQEAVDALLDNGRRGAPVTNPGSDRPLRS LTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQC GLPKRMALELFKPFLLKKMEEKGIAPNVKAARRMLERQRD IKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVE GQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQ MLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGA GLEFATPEEALAAHERGEVALNAPIKVAGRETSVGRLKYV FANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRILF ARIVAEAVEDEKVAWELIQLDVPQEKNSLKDLVYQAFLRL GMEKTARLLDALKYYGFTFSTTSGITIGIDDAVIPEEKKQ YLEEADRKLLQIEQAYEMGFLTDRERYDQILQLWTETTEK VTQAVFKNFEENYPFNPLYVMAQSGARGNPQQIRQLCGLR GLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGGA DTALRTADSGYLTRKLVDVTHEIVVREADCGTTNYISVPL FQPDEVTRSLRLRKRADIEAGLYGRVLAREVEVLGVRLEE GRYLSMDDVHLLIKAAEAGEIQEVPVRSPLTCQTRYGVCQ KCYGYDLSMARPVSIGEAVGIVAAQSIGEPGTQLTMRTFH TGGVAGAADITQGLPRVIELFEARRPKAKAVISEIDGVVR IEETEEKLSVFVESEGFSKEYKLPKEARLLVKDGDYVEAG QPLTRGAIDPHQLLEAKGPEAVERYLVEEIQKVYRAQGVK LHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQVLEKWDVEA LNERLIAEGKTPVAWKPLLMGVTKSALSTKSWLSAASFQN TTHVLTEAAIAGKKDELIGLKENVILGRLIPAGTGSDFVR FTQVVDQKTLKAIEEA Description Functional site 1) chain D residue 840 type sequence K description binding site for residue MG D 1601 source : AC3 2) chain D residue 1112 type sequence C description binding site for residue ZN D 1602 source : AC4 3) chain D residue 1194 type sequence C description binding site for residue ZN D 1602 source : AC4 4) chain D residue 1201 type sequence C description binding site for residue ZN D 1602 source : AC4 5) chain D residue 1204 type sequence C description binding site for residue ZN D 1602 source : AC4 6) chain D residue 58 type sequence C description binding site for residue ZN D 1603 source : AC5 7) chain D residue 60 type sequence C description binding site for residue ZN D 1603 source : AC5 8) chain D residue 62 type sequence K description binding site for residue ZN D 1603 source : AC5 9) chain D residue 73 type sequence C description binding site for residue ZN D 1603 source : AC5 10) chain D residue 76 type sequence C description binding site for residue ZN D 1603 source : AC5 11) chain D residue 739 type sequence D description binding site for residue MG D 1604 source : AC6 12) chain D residue 741 type sequence D description binding site for residue MG D 1604 source : AC6 13) chain D residue 743 type sequence D description binding site for residue MG D 1604 source : AC6 14) chain D residue 704 type sequence R description binding site for residue PUM I 101 source : AC9 15) chain D residue 706 type sequence P description binding site for residue PUM I 101 source : AC9 16) chain D residue 737 type sequence N description binding site for residue PUM I 101 source : AC9 17) chain D residue 1084 type sequence T description binding site for residue PUM I 101 source : AC9 18) chain D residue 1235 type sequence Q description binding site for residue PUM I 101 source : AC9 19) chain D residue 1238 type sequence M description binding site for residue PUM I 101 source : AC9 20) chain D residue 1241 type sequence F description binding site for residue PUM I 101 source : AC9 21) chain D residue 1201 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 1204 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 60 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 73 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 76 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 739 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 741 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 28) chain D residue 743 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 29) chain D residue 1112 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 1194 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1

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