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eF-site ID
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5x07-ABCDEFGHIJKL |
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PDB Code
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5x07 |
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Chain
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A, B, C, D, E, F, G, H, I, J, K, L |
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click to enlarge
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Title
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Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site |
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Classification
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DNA BINDING PROTEIN/DNA |
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Compound
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DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3') |
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Source
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Homo sapiens (Human) (FOXA2_HUMAN) |
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Sequence
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A: |
TCTTGTTTACATTTTG
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| B: |
CAAAATGTAAACAAGA
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| C: |
GPHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFP
FYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWT
LHPD
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| D: |
TCTTGTTTACATTTTG
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| E: |
CAAAATGTAAACAAGA
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| F: |
GPHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFP
FYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWT
LHPDS
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| G: |
TCTTGTTTACATTTTG
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| H: |
CAAAATGTAAACAAGA
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| I: |
HAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFY
RQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLH
PD
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| J: |
TCTTGTTTACATTTTG
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| K: |
CAAAATGTAAACAAGA
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| L: |
GPHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFP
FYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWT
LHPDS
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Description
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(1) |
Hepatocyte nuclear factor 3-beta/DNA Complex
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Functional site
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1)
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chain |
F |
| residue |
159-172 |
| type |
prosite |
| sequence |
KPPYSYISLITMAI
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| description |
FORK_HEAD_1 Fork head domain signature 1. KPPYSYisLitm.AI
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| source |
prosite : PS00657
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2)
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chain |
F |
| residue |
203-209 |
| type |
prosite |
| sequence |
WQNSIRH
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| description |
FORK_HEAD_2 Fork head domain signature 2. WQNSIRH
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| source |
prosite : PS00658
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3)
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chain |
F |
| residue |
212 |
| type |
MOD_RES |
| sequence |
S
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| description |
Phosphoserine => ECO:0000250|UniProtKB:P32182
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| source |
Swiss-Prot : SWS_FT_FI2
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4)
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chain |
C |
| residue |
212 |
| type |
MOD_RES |
| sequence |
S
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| description |
Phosphoserine => ECO:0000250|UniProtKB:P32182
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| source |
Swiss-Prot : SWS_FT_FI2
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5)
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chain |
I |
| residue |
212 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P32182
|
| source |
Swiss-Prot : SWS_FT_FI2
|
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6)
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chain |
L |
| residue |
212 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P32182
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| source |
Swiss-Prot : SWS_FT_FI2
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