eF-site ID 5wzz-ABCDEFGH
PDB Code 5wzz
Chain A, B, C, D, E, F, G, H

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Title The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation
Classification LIGASE
Compound E3 ubiquitin-protein ligase SIAH1
Source Homo sapiens (Human) (AXIN1_HUMAN)
Sequence A:  SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINL
PGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLI
GTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIM
NSDCLVFDTSIAQLFAENGNLGINVTISMC
B:  SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINL
PGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLI
GTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIM
NSDCLVFDTSIAQLFAENGNLGINVTISMC
C:  SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINL
PGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLI
GTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIM
NSDCLVFDTSIAQLFAENGNLGINVTISMC
D:  SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINL
PGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLI
GTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIM
NSDCLVFDTSIAQLFAENGNLGINVTISMC
E:  VPKEVRVEPQK
F:  KEVRVEPQK
G:  PKEVRVEPQK
H:  VPKEVRVEPQK
Description


Functional site
1) chain A
residue 98
type
sequence C
description binding site for residue ZN A 301
source : AC1
2) chain A
residue 105
type
sequence C
description binding site for residue ZN A 301
source : AC1
3) chain A
residue 117
type
sequence H
description binding site for residue ZN A 301
source : AC1
4) chain A
residue 121
type
sequence C
description binding site for residue ZN A 301
source : AC1
5) chain A
residue 128
type
sequence C
description binding site for residue ZN A 302
source : AC2
6) chain A
residue 135
type
sequence C
description binding site for residue ZN A 302
source : AC2
7) chain A
residue 147
type
sequence H
description binding site for residue ZN A 302
source : AC2
8) chain A
residue 152
type
sequence H
description binding site for residue ZN A 302
source : AC2
9) chain B
residue 98
type
sequence C
description binding site for residue ZN B 301
source : AC3
10) chain B
residue 105
type
sequence C
description binding site for residue ZN B 301
source : AC3
11) chain B
residue 117
type
sequence H
description binding site for residue ZN B 301
source : AC3
12) chain B
residue 121
type
sequence C
description binding site for residue ZN B 301
source : AC3
13) chain B
residue 128
type
sequence C
description binding site for residue ZN B 302
source : AC4
14) chain B
residue 135
type
sequence C
description binding site for residue ZN B 302
source : AC4
15) chain B
residue 147
type
sequence H
description binding site for residue ZN B 302
source : AC4
16) chain B
residue 152
type
sequence H
description binding site for residue ZN B 302
source : AC4
17) chain C
residue 98
type
sequence C
description binding site for residue ZN C 301
source : AC5
18) chain C
residue 105
type
sequence C
description binding site for residue ZN C 301
source : AC5
19) chain C
residue 117
type
sequence H
description binding site for residue ZN C 301
source : AC5
20) chain C
residue 121
type
sequence C
description binding site for residue ZN C 301
source : AC5
21) chain C
residue 128
type
sequence C
description binding site for residue ZN C 302
source : AC6
22) chain C
residue 135
type
sequence C
description binding site for residue ZN C 302
source : AC6
23) chain C
residue 147
type
sequence H
description binding site for residue ZN C 302
source : AC6
24) chain C
residue 152
type
sequence H
description binding site for residue ZN C 302
source : AC6
25) chain D
residue 98
type
sequence C
description binding site for residue ZN D 301
source : AC7
26) chain D
residue 105
type
sequence C
description binding site for residue ZN D 301
source : AC7
27) chain D
residue 117
type
sequence H
description binding site for residue ZN D 301
source : AC7
28) chain D
residue 121
type
sequence C
description binding site for residue ZN D 301
source : AC7
29) chain D
residue 128
type
sequence C
description binding site for residue ZN D 302
source : AC8
30) chain D
residue 135
type
sequence C
description binding site for residue ZN D 302
source : AC8
31) chain D
residue 147
type
sequence H
description binding site for residue ZN D 302
source : AC8
32) chain D
residue 152
type
sequence H
description binding site for residue ZN D 302
source : AC8
33) chain A
residue 93-153
type ZN_FING
sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHK
description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455
source Swiss-Prot : SWS_FT_FI1
34) chain B
residue 93-153
type ZN_FING
sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHK
description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455
source Swiss-Prot : SWS_FT_FI1
35) chain C
residue 93-153
type ZN_FING
sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHK
description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455
source Swiss-Prot : SWS_FT_FI1
36) chain D
residue 93-153
type ZN_FING
sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG
ASCKWQGSLDAVMPHLMHQHK
description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455
source Swiss-Prot : SWS_FT_FI1
37) chain A
residue 98
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
38) chain C
residue 105
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
39) chain C
residue 117
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
40) chain C
residue 121
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
41) chain D
residue 98
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
42) chain D
residue 105
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
43) chain D
residue 117
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
44) chain D
residue 121
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
45) chain A
residue 105
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
46) chain A
residue 117
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
47) chain A
residue 121
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
48) chain B
residue 98
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
49) chain B
residue 105
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
50) chain B
residue 117
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
51) chain B
residue 121
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
52) chain C
residue 98
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI2
53) chain A
residue 128
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
54) chain C
residue 135
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
55) chain C
residue 147
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
56) chain C
residue 152
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
57) chain D
residue 128
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
58) chain D
residue 135
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
59) chain D
residue 147
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
60) chain D
residue 152
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
61) chain A
residue 135
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
62) chain A
residue 147
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
63) chain A
residue 152
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
64) chain B
residue 128
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
65) chain B
residue 135
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
66) chain B
residue 147
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
67) chain B
residue 152
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3
68) chain C
residue 128
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ
source Swiss-Prot : SWS_FT_FI3

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