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eF-site ID
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5wwu-A |
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PDB Code
|
5wwu |
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Chain
|
A |
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click to enlarge
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Title
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Crystal Structure of HLA-A*2402 in complex with 2009 pandemic influenza A(H1N1) virus and avian influenza A(H5N1) virus-derived peptide H1-25 |
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Classification
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IMMUNE SYSTEM |
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Compound
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HLA class I histocompatibility antigen, A-24 alpha chain |
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Source
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(5WWU) |
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Sequence
|
A: |
GSHSMRYFSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDA
ASQRMEPRAPWIEQEGPEYWDEETGKVKAHSQTDRENLRI
ALRYYNQSEAGSHTLQMMFGCDVGSDGRFLRGYHQYAYDG
KDYIALKEDLRSWTAADMAAQITKRKWEAAHVAEQQRAYL
EGTCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEAT
LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW
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Description
|
(1) |
HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, LEU-TYR-LYS-LYS-LEU-LYS-ARG-GLU-ILE-THR-PHE
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Functional site
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1)
|
chain |
A |
| residue |
86 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
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| source |
Swiss-Prot : SWS_FT_FI4
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2)
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chain |
A |
| residue |
73 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
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| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
|
chain |
A |
| residue |
84 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
A |
| residue |
143 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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5)
|
chain |
A |
| residue |
146 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
A |
| residue |
171 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
A |
| residue |
159 |
| type |
CARBOHYD |
| sequence |
Y
|
| description |
N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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8)
|
chain |
A |
| residue |
257-263 |
| type |
prosite |
| sequence |
YTCHVQH
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| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH
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| source |
prosite : PS00290
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