eF-site ID 5wwp-AB PDB Code 5wwp Chain A, B click to enlarge Title Crystal structure of Middle East respiratory syndrome coronavirus helicase (MERS-CoV nsp13) Classification HYDROLASE Compound ORF1ab Source Human betacoronavirus 2c EMC/2012 (K0BWD0_9BETC) Sequence A:  PAVGSCVVCHSQTSLRCGTCIRRPFLCCKCCYDHVIATPH KMVLSVSPYVCNAPGCGVSDVTKLYLGGMSYFCVDHRPVC SFPLCANGLVFGLYKNMCTGSPSIVEFNRLATCDWTESGD YTLANTTTEPLKLFAAETLRATEEASKSVATLTAPTIVNQ ERYVKITGLYPTITVPEEFASHVANFQKSGYSKYVTVQGP PGTGKSHFAIGLAIYYPTARVVYTACSHAAVDALCEKAFK YLNIAKCSRIIPAKARVECYDRFKVNETNSQYLFSTINAL PETSADILVVDEVSMCTNYDLSIINARIKAKHIVYVGDPA QLPAPRTLLTRGTLEPENFNSVTRLMCNLGPDIFLSMCYR CPKEIVSTVSALVYNNKLLAKKELSGQCFKILYKGNVTHD ASSAINRPQLTFVKNFITANPAWSKAVFISPYNSQNAVSR SMLGLTTQTVDSSQGSEYQYVIFCQTADTAHANNINRFNV AITRAQKGILCVMTSQALFESLEFTELSFTNYKLQ B:  PAVGSCVVCHSQTSLRCGTCIRRPFLCCKCCYDHVIATPH KMVLSVSPYVCNAPGCGVSDVTKLYLGGMSYFCVDHRPVC SFPLCANGLVFGLYKNMCTGSPSIVEFNRLATCDWTESGD YTLANTTTEPLKLFAAETLRATEEASKQSYAIATIKEIVG ERQLLLVWEAGKSKPPLNRNYVFTGYKVQLGEYIFERIDY SDAVSYKSSTTYKLTVGDIFVLTSHSVATLTAPTIVNQER YVKITGLYPTITVPEEFASHVANFQKSGYSKYVTVQGPPG TGKSHFAIGLAIYYPTARVVYTACSHAAVDALCEKAFKYL NIAKCSRIIPAKARVECYDRFKVNETNSQYLFSTINALPE TSADILVVDEVSMCTNYDLSIINARIKAKHIVYVGDPAQL PAPRTLLTRGTLEPENFNSVTRLMCNLGPDIFLSMCYRCP KEIVSTVSALVYNNKLLAKKELSGQCFKILYKGNVTHDAS SAINRPQLTFVKNFITANPAWSKAVFISPYNSQNAVSRSM LGLTTQTVDSSQGSEYQYVIFCQTADTAHANNINRFNVAI TRAQKGILCVMTSQALFESLEFTELSFTNYK Description Functional site 1) chain B residue 5 type sequence C description binding site for residue ZN B 601 source : AC1 2) chain B residue 8 type sequence C description binding site for residue ZN B 601 source : AC1 3) chain B residue 26 type sequence C description binding site for residue ZN B 601 source : AC1 4) chain B residue 29 type sequence C description binding site for residue ZN B 601 source : AC1 5) chain B residue 16 type sequence C description binding site for residue ZN B 602 source : AC2 6) chain B residue 19 type sequence C description binding site for residue ZN B 602 source : AC2 7) chain B residue 33 type sequence H description binding site for residue ZN B 602 source : AC2 8) chain B residue 39 type sequence H description binding site for residue ZN B 602 source : AC2 9) chain B residue 50 type sequence C description binding site for residue ZN B 603 source : AC3 10) chain B residue 55 type sequence C description binding site for residue ZN B 603 source : AC3 11) chain B residue 72 type sequence C description binding site for residue ZN B 603 source : AC3 12) chain B residue 75 type sequence H description binding site for residue ZN B 603 source : AC3 13) chain B residue 284 type sequence P description binding site for residue SO4 B 604 source : AC4 14) chain B residue 285 type sequence G description binding site for residue SO4 B 604 source : AC4 15) chain B residue 288 type sequence K description binding site for residue SO4 B 604 source : AC4 16) chain B residue 443 type sequence R description binding site for residue SO4 B 604 source : AC4 17) chain A residue 5 type sequence C description binding site for residue ZN A 601 source : AC5 18) chain A residue 8 type sequence C description binding site for residue ZN A 601 source : AC5 19) chain A residue 26 type sequence C description binding site for residue ZN A 601 source : AC5 20) chain A residue 29 type sequence C description binding site for residue ZN A 601 source : AC5 21) chain A residue 16 type sequence C description binding site for residue ZN A 602 source : AC6 22) chain A residue 19 type sequence C description binding site for residue ZN A 602 source : AC6 23) chain A residue 33 type sequence H description binding site for residue ZN A 602 source : AC6 24) chain A residue 50 type sequence C description binding site for residue ZN A 603 source : AC7 25) chain A residue 55 type sequence C description binding site for residue ZN A 603 source : AC7 26) chain A residue 72 type sequence C description binding site for residue ZN A 603 source : AC7 27) chain A residue 75 type sequence H description binding site for residue ZN A 603 source : AC7 28) chain A residue 380 type sequence T description binding site for residue SO4 A 604 source : AC8 29) chain A residue 381 type sequence N description binding site for residue SO4 A 604 source : AC8 30) chain A residue 409 type sequence R description binding site for residue SO4 A 604 source : AC8 31) chain A residue 422 type sequence F description binding site for residue SO4 A 604 source : AC8 32) chain A residue 486 type sequence S description binding site for residue SO4 A 605 source : AC9 33) chain A residue 515 type sequence Y description binding site for residue SO4 A 605 source : AC9 34) chain A residue 516 type sequence N description binding site for residue SO4 A 605 source : AC9 35) chain A residue 285 type sequence G description binding site for residue SO4 A 606 source : AD1 36) chain A residue 286 type sequence T description binding site for residue SO4 A 606 source : AD1 37) chain A residue 287 type sequence G description binding site for residue SO4 A 606 source : AD1 38) chain A residue 288 type sequence K description binding site for residue SO4 A 606 source : AD1 39) chain A residue 284 type sequence P description binding site for residue SO4 A 607 source : AD2 40) chain A residue 285 type sequence G description binding site for residue SO4 A 607 source : AD2 41) chain A residue 404 type sequence Q description binding site for residue SO4 A 607 source : AD2 42) chain A residue 443 type sequence R description binding site for residue SO4 A 607 source : AD2 43) chain A residue 538 type sequence G description binding site for residue SO4 A 607 source : AD2 44) chain A residue 567 type sequence R description binding site for residue SO4 A 607 source : AD2

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