|
|
eF-site ID
|
5wob-G |
|
PDB Code
|
5wob |
|
Chain
|
G |
|
click to enlarge
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Title
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Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin |
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Classification
|
HYDROLASE |
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Compound
|
Insulin-degrading enzyme |
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Source
|
(5WOB) |
|
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Sequence
|
G: |
NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTT
DKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLKKYPKEN
EYQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFA
QFFLSFDESAKDREVNAVDSHEKNVMNAWRLFQLEKATGN
PKHPFSKFTGNKYTLTRPNQEGIDVRQELLKFHSAYYSSN
LMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHP
FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGH
YLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMF
FIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ
ELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTA
EYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRT
EEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIP
TNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKA
NLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAE
LAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATF
EIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTE
VAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGN
ITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLP
DRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFA
QIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQS
EKPPHYLESRVEAFLITMEKSIEDMTEEAQKHIQALAIRR
LDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTK
EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSNSQAPALP
QPEVIQNMTEFKRGLPLFPLVKP
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
G |
| residue |
108 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN G 2001
|
| source |
: AC7
|
|
|
2)
|
chain |
G |
| residue |
112 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN G 2001
|
| source |
: AC7
|
|
|
3)
|
chain |
G |
| residue |
192 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
4)
|
chain |
G |
| residue |
697 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
5)
|
chain |
G |
| residue |
111 |
| type |
ACT_SITE |
| sequence |
Q
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
G |
| residue |
108 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
G |
| residue |
112 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
G |
| residue |
336 |
| type |
BINDING |
| sequence |
H
|
| description |
in the exosite
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
9)
|
chain |
G |
| residue |
359 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000269|PubMed:18986166
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
10)
|
chain |
G |
| residue |
429 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
11)
|
chain |
G |
| residue |
895 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|