|
|
eF-site ID
|
5wob-ABCDEFGHIJKLMNOPQRSTUVWXabcdefgh |
|
PDB Code
|
5wob |
|
Chain
|
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, a, b, c, d, e, f, g, h |
|
|
|
|
Title
|
Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin |
|
Classification
|
HYDROLASE |
|
Compound
|
Insulin-degrading enzyme |
|
Source
|
(5WOB) |
|
|
Sequence
|
A: |
NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTT
DKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPK
ENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD
RFAQFFLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEK
ATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHA
YYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPE
FPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYK
SNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGA
RGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQ
EWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLE
EVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEG
KTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTK
NEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKF
FLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEY
AYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIE
KMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLR
LLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEA
LLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYR
EVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMF
LELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLR
FIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQ
ALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAY
LKTLTKDIIKFYKEMLVDAPRRHKVSVHVLAQAPALPQPE
VIQNMTEFKRGLPLFPLVKPH
|
| B: |
PAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTD
KSSAALDVHIGSLSDPPNAGLSHFLQHMLFLKKYPKENEY
SQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQ
FFPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATG
NPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYY
SSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFP
EHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSN
PGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARG
FMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEW
VFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEV
LTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKT
DRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNE
FIPTNFEILPLEKETPYPALIKDTAMSKLWFKQDDKFFLP
KANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYA
AELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMA
TFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLM
TEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLH
GNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQ
LPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLEL
FAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFII
QSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALA
IRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKT
LTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSNNLSQ
APALPQPEVIQNMTEFKRGLPLFPLVK
|
| C: |
NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTT
DKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPK
ENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD
RFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQ
LEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLK
FHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNV
PLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQ
KYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQ
KEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRA
EGPQEWVFQELKDLNAVAFRFKDKERPRGYTSIAGILHYY
PLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKS
FEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKL
PTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQD
DKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSL
NEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKK
IIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMY
YLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLH
IEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLV
RYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSE
NMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQ
GLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQK
HIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTE
VAYLKTLTKDIIKFYKEMLAVDAPRRHKVSVHVLAREMDS
APALPQPEVIQNMTEFKRGLPLFPLVKPHI
|
| D: |
NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTT
DKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPK
ENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD
RFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQ
LEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLK
FHSAYYSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVP
LPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQK
YYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQK
EGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAE
GPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYY
PLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKS
FEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKL
PTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQD
DKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSL
NEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKK
IIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMY
YLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLH
IEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLV
RYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSE
NMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQ
GLRFIIQSEKPPHYLESRVEAFLITMEIEDMTEEAFQKHI
QALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVA
YLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSN
NLSQAPALPQPEVIQNMTEFKRGLPLFPLVKP
|
| E: |
NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTT
DKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLKKYPKEN
EYQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFA
FFSPFDSAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGN
PKHPFSKFGTGNKYTLTRPNQEGIDVRQELLKFHSAYYSS
NLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH
PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPG
HYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFM
FFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVF
QELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLT
AEYLLEEPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTE
EWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPT
NFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKAN
LNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAEL
AGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFE
IDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEV
AWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNI
TKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPD
RGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQ
IISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSE
KPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRR
LDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTK
EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSNSQAPALP
QPEVIQNMTEFKRGLPLFPLVKP
|
| F: |
NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTT
DKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPK
ENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD
RFAQFFLSPLFDEKDREVNAVDSEHEKNVMNDAWRLFQLE
KATGNPKHPFSKFGTGNKYTLTRPNQEGIDVRQELLKFHS
AYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLP
EFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYY
KSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEG
ARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGP
QEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPL
EEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFE
GKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPT
KNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDK
FLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEY
AYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIE
KMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLR
LLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEA
LLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYR
EVQLPDRGWFVYQQRNEVHNNGIEIYYQTDMQSTSENMFL
ELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRF
IIQSEKPPHYLESRVEAFLITMEKSIETEFQKHIQALAIR
RLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLT
KEDIIKFYKEMLAVDPRRHKVSVHVLAREMINLSQAPALP
QPEVIQNMTEFKRGLPLFPLVKPH
|
| G: |
NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTT
DKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLKKYPKEN
EYQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFA
QFFLSFDESAKDREVNAVDSHEKNVMNAWRLFQLEKATGN
PKHPFSKFTGNKYTLTRPNQEGIDVRQELLKFHSAYYSSN
LMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHP
FQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGH
YLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMF
FIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ
ELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTA
EYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRT
EEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIP
TNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKA
NLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAE
LAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATF
EIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTE
VAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGN
ITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLP
DRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFA
QIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQS
EKPPHYLESRVEAFLITMEKSIEDMTEEAQKHIQALAIRR
LDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTK
EDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSNSQAPALP
QPEVIQNMTEFKRGLPLFPLVKP
|
| H: |
NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTT
DKSSAALDVHIGSLSDPPNAGLSHFLQHMLFLGTKKYPNE
YSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFA
QFFLSPLFDEAKDREVNAVDSEHEKNVMNDAWRLFQLEKA
TGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSA
YYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPE
FPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYK
SNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGA
RGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQ
EWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLE
EVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEG
KTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTK
NEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKF
FLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEY
AYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIE
KMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLR
LLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEA
LLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYR
EVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMF
LELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLR
FIIQSEKPPHYLESRVEAFLITMEKSIEFQKHIQALAIRR
LDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTK
EDIIKFYKEMLAVDAPRRHKVSVHVLARAPALPQPEVIQN
MTEFKRGLPLFPLVKP
|
| I: |
EVQLVESGGGLVQPGGSLRLSCAASGFNVSSYSIHWVRQA
PGKGLEWVASISSYYGSTSYADSVKGRFTISADTNTAYLQ
MNSLRAEDTAVYYCARDRVMYYWSFSKYGYPYGMDYWGQG
TLVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSTYICNVN
HKPSNTKVDKKVEPK
|
| J: |
MTQSPSSLSASVGDRVTITCRAVSSAVAWYQQKPGKAPKL
LIYSTSSLYSGVPSRFSGSRSTDFTLTISSLQPEDFATYY
CQQSSPSFLITFGQGTKVEIKRTVAAPSVFIFPPSDSQLK
SASVVCLLNNFYPREAKVQWKALSGNSQESVTEQDSKDST
YSLSSTLTLSKADYEKHKVYCEVTHQGLSSPVTKSFNR
|
| K: |
EVQLVESGGGLVQPGGSLRLSCAASGFNVSSYSIHWVRQA
PGKGLEWVASISSYYGSTSYADSVKGRFTISADTNTAYLQ
MNSLRAEDAVYYCARDRVMYYWSFSKYGYPYGMDYWGQGT
LVTVSSASTKGPSVFPLAPSSGCLVKDYFPEPVTVSWNSG
VHTFPAVLQSSGLYSLSSVVTVPSSTYICNVNHKPSNTKV
DKKVEPK
|
| L: |
MTQSPSSLSASVGDRVTITCRAVSSAVAWYQQKPGKAPKL
LIYSTSSLYSGVPSRFSGSRSTDFTLTISSLQPEDFATYY
CQQSSPSFLITFGQGTKVEIKRVAAPSVFIFPPSDSQLKS
SVVCLLNNFYPREAKVQWKSGNSQESVTEQDSKDSTYSLS
STLTYEKHKVTHQGLS
|
| M: |
EVQLVESGGGLVQPGGSLRLSCAASGFNVSSYSIHWVRQA
PGKGLEWVASISSYYGSTSYADSVKGRFTISADTNTAYLQ
MNSLRAEDTAVYYCARDRVMYYWSFSKYGYPYGMDYWGQG
TLVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSTYICNVN
HKPSNTKVDKKVEP
|
| N: |
MTQSPSSLSASVGDRVTITCRAVSSAVAWYQQKPGKAPKL
LIYSTSSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATY
YCQQSSPSFLITFGQGTKVEIKRTVAAPSVFIFPPSDSQL
KSASVVCLLNNFYPREAKVQWKALSGNSQESVTEQDSKDS
TYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR
|
| O: |
EVQLVESGGGLVQPGGSLRLSCAASGFNVSSYSIHWVRQA
PGKGLEWVASISSYYGSTSYADSVKGRFTISADTNTAYLQ
MNSLRAEDTAVYYCARDRVMYYWSFSKYGYPYGMDYWGQG
TLVTVSSASTKGPSVFPLAPSSLGCLVKDYFPEPVTVSWN
SGALSGVHTFPAVLQSSGLYSLSSVVTVPSSNVNHKPSNT
KVDKKVEPK
|
| P: |
MTQSPSSLSASVGDRVTITCRAVSSAVAWYQQKPGKAPKL
LIYSTSSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATY
YCQQSSPSFLITFGQGTKVEIKRTVAAPSVFIFPPSDSQL
KASVVCLLNNFYPREAKVQWKALSGNSQESVTEQDSKDST
YSLSSTLYEKHKCVTHQGTKSFNR
|
| Q: |
EVQLVESGGGLVQPGSLRLSCAASGFNVSSYSIHWVRQAP
GKGLEWVASISSYYGSTYADSVKGRFTISADTNTAYLQSL
RAEDAVYYCARDRVMYYWSFSKYGYPYGMDYWGQGTLVTV
SSASTKGPSVFPLAPSSGCLVKDYFPEPVTVSWNSGALSG
VHTFPAVLQSSGLYSLSSVVTYICNVNHKSNTKVDKKVEP
K
|
| R: |
MTQSPSSLSASVGDRVTITCRAVSSAVAWYQQKPGKAPKL
LIYSTSSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATY
YCQQSSPSFLITFGQGTKVEIKRTVAAPSVFIFPPSDSQL
KSVCLLNNFYPREASGNSQESVTEQDSKDSTYSLSSTLSK
ADYEKHKVYATHQGLSS
|
| S: |
EVQLVESGGGLVQPGGSLRLSCAASGFNVSSYSIHWVRQA
PGKGLEWVASISSYYGSTSYADSVKGRFTISADTNTAYLQ
MNSLRAEDTAVYYCARDRVMYYWSFSKYGYPYGMDYWGQG
TLVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSTYICNVN
HKPSNTKVDKKVEPK
|
| T: |
MTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKA
PKLLIYSTSSLYSGVPSRFSGSRSTDFTLTISSLQPEDFA
TYYCQQSSPSFLITFGQGTKVEIKRTVAAPSVFIFPPSDS
QLKSASVVCLLNNFYPREAKVQWKSGNSQESVTEQDSKDS
TYSLSSTLTLSKADYEKHKVACEVTHQGLSSPVTKFNR
|
| U: |
EVQLVESGGGLVQPGGSLRLSCAASGFNVSSYSIHWVRQA
PGKGLEWVASISSYYGSTSYADSVKGRFTISADTNTAYLQ
MNSLRAEDTAVYYCARDRVMYYWSFSKYGYPYGMDYWGQG
ASTKGPSVFPLATAALGCLVDYFPEPVTVSWSGALTSGVH
TFPAVLQSSGLYSSVVTVPTYICNVNHKPSNTKVDKKVE
|
| V: |
MTQSPSSLSASVGDRVTITCRAVSSAVAWYQQKPGKAPKL
LIYSTSSLYSGVPSRFSGSRSGTDFTLTISLQPEDFATYY
CQQSSPSFLITFGQGTKVEIKRTVAAPSVFIFPPDSQLKS
NFYPREAKVQWALSGNSQESVTEQDSKDSTYSLSSTLTSK
ADYEKHYACEVTHQGLSSPVTKSFNR
|
| W: |
EVQLVESGGGLVQPGGSLRLSCAASGFNVSSYSIHWVRQA
PGKGLEWVASISSYYGSTSYADSVKGRFTISADTNTAYLQ
MNSLRAEDTAVYYCARDRVMYYWSFSKYGYPYGMDYWGQG
TLVTVSSGPSVFPLAPSSTAALGLVKDYFPEPVTVSWNSG
ALTSGVHTFPAVLQSSGLYSLSSVVTVPSSTYICNVNHKP
SNTK
|
| X: |
TQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAP
KLLIYSTSSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFA
TYYCQQSSPSFLITFGQGTKVEIKRTVAAPSVFIFPPSDS
QLKSASVVCLLNNFYPREAKVQWKSGNSQESVTEQDSKDS
TYSLSSTLTLSKADYEKHKVCEVTHQGLSSPVTKSFNR
|
| a: |
GIVEQCCTSICSLYQLENYC
|
| b: |
GIVEQ
|
| c: |
GIVEQCCTSICSLYQLENYC
|
| d: |
GIV
|
| e: |
GIVEQLYQL
|
| f: |
GIVEQCCTSICSQLENYC
|
| g: |
GIVEQCSLYQLENYC
|
| h: |
GIVEQC
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
108 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN A 1101
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
112 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN A 1101
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
189 |
| type |
|
| sequence |
E
|
| description |
binding site for residue ZN A 1101
|
| source |
: AC1
|
|
|
4)
|
chain |
a |
| residue |
12 |
| type |
|
| sequence |
S
|
| description |
binding site for residue ZN A 1101
|
| source |
: AC1
|
|
|
5)
|
chain |
a |
| residue |
14 |
| type |
|
| sequence |
Y
|
| description |
binding site for residue ZN A 1101
|
| source |
: AC1
|
|
|
6)
|
chain |
B |
| residue |
108 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN B 2001
|
| source |
: AC2
|
|
|
7)
|
chain |
B |
| residue |
112 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN B 2001
|
| source |
: AC2
|
|
|
8)
|
chain |
B |
| residue |
189 |
| type |
|
| sequence |
E
|
| description |
binding site for residue ZN B 2001
|
| source |
: AC2
|
|
|
9)
|
chain |
C |
| residue |
108 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN C 1101
|
| source |
: AC3
|
|
|
10)
|
chain |
C |
| residue |
112 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN C 1101
|
| source |
: AC3
|
|
|
11)
|
chain |
C |
| residue |
189 |
| type |
|
| sequence |
E
|
| description |
binding site for residue ZN C 1101
|
| source |
: AC3
|
|
|
12)
|
chain |
c |
| residue |
14 |
| type |
|
| sequence |
Y
|
| description |
binding site for residue ZN C 1101
|
| source |
: AC3
|
|
|
13)
|
chain |
D |
| residue |
108 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN D 2001
|
| source |
: AC4
|
|
|
14)
|
chain |
D |
| residue |
112 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN D 2001
|
| source |
: AC4
|
|
|
15)
|
chain |
D |
| residue |
189 |
| type |
|
| sequence |
E
|
| description |
binding site for residue ZN D 2001
|
| source |
: AC4
|
|
|
16)
|
chain |
E |
| residue |
108 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN E 2001
|
| source |
: AC5
|
|
|
17)
|
chain |
E |
| residue |
112 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN E 2001
|
| source |
: AC5
|
|
|
18)
|
chain |
E |
| residue |
189 |
| type |
|
| sequence |
E
|
| description |
binding site for residue ZN E 2001
|
| source |
: AC5
|
|
|
19)
|
chain |
F |
| residue |
108 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN F 1101
|
| source |
: AC6
|
|
|
20)
|
chain |
F |
| residue |
112 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN F 1101
|
| source |
: AC6
|
|
|
21)
|
chain |
F |
| residue |
189 |
| type |
|
| sequence |
E
|
| description |
binding site for residue ZN F 1101
|
| source |
: AC6
|
|
|
22)
|
chain |
G |
| residue |
108 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN G 2001
|
| source |
: AC7
|
|
|
23)
|
chain |
G |
| residue |
112 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN G 2001
|
| source |
: AC7
|
|
|
24)
|
chain |
H |
| residue |
108 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN H 1101
|
| source |
: AC8
|
|
|
25)
|
chain |
H |
| residue |
112 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN H 1101
|
| source |
: AC8
|
|
|
26)
|
chain |
H |
| residue |
189 |
| type |
|
| sequence |
E
|
| description |
binding site for residue ZN H 1101
|
| source |
: AC8
|
|
|
27)
|
chain |
a |
| residue |
6-20 |
| type |
prosite |
| sequence |
CCTSICSLYQLENYC
|
| description |
INSULIN Insulin family signature. CCTSiCSlyqLenyC
|
| source |
prosite : PS00262
|
|
|
28)
|
chain |
I |
| residue |
210-216 |
| type |
prosite |
| sequence |
YICNVNH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
| source |
prosite : PS00290
|
|
|
29)
|
chain |
N |
| residue |
193-199 |
| type |
prosite |
| sequence |
YACEVTH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
| source |
prosite : PS00290
|
|
|
30)
|
chain |
A |
| residue |
192 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
31)
|
chain |
E |
| residue |
697 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
32)
|
chain |
F |
| residue |
192 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
33)
|
chain |
F |
| residue |
697 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
34)
|
chain |
G |
| residue |
192 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
35)
|
chain |
G |
| residue |
697 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
36)
|
chain |
H |
| residue |
192 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
37)
|
chain |
H |
| residue |
697 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
38)
|
chain |
A |
| residue |
697 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
39)
|
chain |
B |
| residue |
192 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
40)
|
chain |
B |
| residue |
697 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
41)
|
chain |
C |
| residue |
192 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
42)
|
chain |
C |
| residue |
697 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
43)
|
chain |
D |
| residue |
192 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
44)
|
chain |
D |
| residue |
697 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
45)
|
chain |
E |
| residue |
192 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
46)
|
chain |
A |
| residue |
111 |
| type |
ACT_SITE |
| sequence |
Q
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
47)
|
chain |
B |
| residue |
111 |
| type |
ACT_SITE |
| sequence |
Q
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
48)
|
chain |
C |
| residue |
111 |
| type |
ACT_SITE |
| sequence |
Q
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
49)
|
chain |
D |
| residue |
111 |
| type |
ACT_SITE |
| sequence |
Q
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
50)
|
chain |
E |
| residue |
111 |
| type |
ACT_SITE |
| sequence |
Q
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
51)
|
chain |
F |
| residue |
111 |
| type |
ACT_SITE |
| sequence |
Q
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
52)
|
chain |
G |
| residue |
111 |
| type |
ACT_SITE |
| sequence |
Q
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
53)
|
chain |
H |
| residue |
111 |
| type |
ACT_SITE |
| sequence |
Q
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
54)
|
chain |
D |
| residue |
108 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
55)
|
chain |
D |
| residue |
112 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
56)
|
chain |
D |
| residue |
189 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
57)
|
chain |
E |
| residue |
108 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
58)
|
chain |
E |
| residue |
112 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
59)
|
chain |
E |
| residue |
189 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
60)
|
chain |
F |
| residue |
108 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
61)
|
chain |
F |
| residue |
112 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
62)
|
chain |
F |
| residue |
189 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
63)
|
chain |
G |
| residue |
108 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
64)
|
chain |
G |
| residue |
112 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
65)
|
chain |
H |
| residue |
108 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
66)
|
chain |
H |
| residue |
112 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
67)
|
chain |
H |
| residue |
189 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
68)
|
chain |
C |
| residue |
189 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
69)
|
chain |
A |
| residue |
108 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
70)
|
chain |
A |
| residue |
112 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
71)
|
chain |
A |
| residue |
189 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
72)
|
chain |
B |
| residue |
108 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
73)
|
chain |
B |
| residue |
112 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
74)
|
chain |
B |
| residue |
189 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
75)
|
chain |
C |
| residue |
108 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
76)
|
chain |
C |
| residue |
112 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
77)
|
chain |
A |
| residue |
336 |
| type |
BINDING |
| sequence |
H
|
| description |
in the exosite
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
78)
|
chain |
B |
| residue |
336 |
| type |
BINDING |
| sequence |
H
|
| description |
in the exosite
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
79)
|
chain |
C |
| residue |
336 |
| type |
BINDING |
| sequence |
H
|
| description |
in the exosite
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
80)
|
chain |
D |
| residue |
336 |
| type |
BINDING |
| sequence |
H
|
| description |
in the exosite
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
81)
|
chain |
E |
| residue |
336 |
| type |
BINDING |
| sequence |
H
|
| description |
in the exosite
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
82)
|
chain |
F |
| residue |
336 |
| type |
BINDING |
| sequence |
H
|
| description |
in the exosite
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
83)
|
chain |
G |
| residue |
336 |
| type |
BINDING |
| sequence |
H
|
| description |
in the exosite
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
84)
|
chain |
H |
| residue |
336 |
| type |
BINDING |
| sequence |
H
|
| description |
in the exosite
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
85)
|
chain |
A |
| residue |
359 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000269|PubMed:18986166
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
86)
|
chain |
B |
| residue |
359 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000269|PubMed:18986166
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
87)
|
chain |
C |
| residue |
359 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000269|PubMed:18986166
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
88)
|
chain |
D |
| residue |
359 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000269|PubMed:18986166
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
89)
|
chain |
E |
| residue |
359 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000269|PubMed:18986166
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
90)
|
chain |
F |
| residue |
359 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000269|PubMed:18986166
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
91)
|
chain |
G |
| residue |
359 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000269|PubMed:18986166
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
92)
|
chain |
H |
| residue |
359 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000269|PubMed:18986166
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
93)
|
chain |
A |
| residue |
429 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
94)
|
chain |
A |
| residue |
895 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
95)
|
chain |
B |
| residue |
429 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
96)
|
chain |
B |
| residue |
895 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
97)
|
chain |
C |
| residue |
429 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
98)
|
chain |
C |
| residue |
895 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
99)
|
chain |
D |
| residue |
429 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
100)
|
chain |
D |
| residue |
895 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
101)
|
chain |
E |
| residue |
429 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
102)
|
chain |
E |
| residue |
895 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
103)
|
chain |
F |
| residue |
429 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
104)
|
chain |
F |
| residue |
895 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
105)
|
chain |
G |
| residue |
429 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
106)
|
chain |
G |
| residue |
895 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
107)
|
chain |
H |
| residue |
429 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
108)
|
chain |
H |
| residue |
895 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250|UniProtKB:P35559
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|