|
eF-site ID
|
5wj6-D |
PDB Code
|
5wj6 |
Chain
|
D |
|
click to enlarge
|
|
Title
|
Crystal structure of glutaminase C in complex with inhibitor 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (UPGL-00004) |
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
Compound
|
Glutaminase kidney isoform, mitochondrial |
Source
|
(GLSK_HUMAN) |
|
Sequence
|
D: |
PSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLK
ECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFR
RKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKF
SPDLWGVSVCTADGQRHSTGDTKVPFCLQSCVKPLKYAIA
VNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNA
GAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNA
TFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQ
LCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNT
LSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVM
GMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHF
AKKLDPRREG
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
D |
residue |
320 |
type |
|
sequence |
K
|
description |
binding site for residue B4A A 601
|
source |
: AC1
|
|
2)
|
chain |
D |
residue |
321 |
type |
|
sequence |
L
|
description |
binding site for residue B4A A 601
|
source |
: AC1
|
|
3)
|
chain |
D |
residue |
322 |
type |
|
sequence |
F
|
description |
binding site for residue B4A A 601
|
source |
: AC1
|
|
4)
|
chain |
D |
residue |
323 |
type |
|
sequence |
L
|
description |
binding site for residue B4A A 601
|
source |
: AC1
|
|
5)
|
chain |
D |
residue |
324 |
type |
|
sequence |
N
|
description |
binding site for residue B4A A 601
|
source |
: AC1
|
|
6)
|
chain |
D |
residue |
325 |
type |
|
sequence |
E
|
description |
binding site for residue B4A A 601
|
source |
: AC1
|
|
7)
|
chain |
D |
residue |
394 |
type |
|
sequence |
Y
|
description |
binding site for residue B4A A 601
|
source |
: AC1
|
|
8)
|
chain |
D |
residue |
286 |
type |
BINDING |
sequence |
S
|
description |
BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
9)
|
chain |
D |
residue |
335 |
type |
BINDING |
sequence |
N
|
description |
BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
10)
|
chain |
D |
residue |
381 |
type |
BINDING |
sequence |
E
|
description |
BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
11)
|
chain |
D |
residue |
414 |
type |
BINDING |
sequence |
Y
|
description |
BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
12)
|
chain |
D |
residue |
466 |
type |
BINDING |
sequence |
Y
|
description |
BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
13)
|
chain |
D |
residue |
484 |
type |
BINDING |
sequence |
V
|
description |
BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
14)
|
chain |
D |
residue |
388 |
type |
BINDING |
sequence |
N
|
description |
BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP1
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
15)
|
chain |
D |
residue |
164 |
type |
MOD_RES |
sequence |
K
|
description |
N6-succinyllysine => ECO:0000250|UniProtKB:D3Z7P3
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
16)
|
chain |
D |
residue |
311 |
type |
MOD_RES |
sequence |
K
|
description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|