eF-site ID 5wj6-C PDB Code 5wj6 Chain C click to enlarge Title Crystal structure of glutaminase C in complex with inhibitor 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (UPGL-00004) Classification HYDROLASE/HYDROLASE INHIBITOR Compound Glutaminase kidney isoform, mitochondrial Source (GLSK_HUMAN) Sequence C:  PSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLK ECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFR RKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKF SPDLWGVSVCTADGQRHSTGDTKVPFCLQSCVKPLKYAIA VNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNA GAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNA TFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQ LCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNT LSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVM GMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHF AKKLDPRREG Description Functional site 1) chain C residue 320 type sequence K description binding site for residue B4A C 601 source : AC2 2) chain C residue 321 type sequence L description binding site for residue B4A C 601 source : AC2 3) chain C residue 322 type sequence F description binding site for residue B4A C 601 source : AC2 4) chain C residue 323 type sequence L description binding site for residue B4A C 601 source : AC2 5) chain C residue 324 type sequence N description binding site for residue B4A C 601 source : AC2 6) chain C residue 325 type sequence E description binding site for residue B4A C 601 source : AC2 7) chain C residue 394 type sequence Y description binding site for residue B4A C 601 source : AC2 8) chain C residue 388 type BINDING sequence N description BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP1 source Swiss-Prot : SWS_FT_FI2 9) chain C residue 164 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:D3Z7P3 source Swiss-Prot : SWS_FT_FI4 10) chain C residue 311 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 11) chain C residue 466 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1 source Swiss-Prot : SWS_FT_FI1 12) chain C residue 484 type BINDING sequence V description BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1 source Swiss-Prot : SWS_FT_FI1 13) chain C residue 286 type BINDING sequence S description BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1 source Swiss-Prot : SWS_FT_FI1 14) chain C residue 335 type BINDING sequence N description BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1 source Swiss-Prot : SWS_FT_FI1 15) chain C residue 381 type BINDING sequence E description BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1 source Swiss-Prot : SWS_FT_FI1 16) chain C residue 414 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:22049910, ECO:0000269|PubMed:22538822, ECO:0000305|PubMed:24451979, ECO:0007744|PDB:3CZD, ECO:0007744|PDB:3UNW, ECO:0007744|PDB:3VP0, ECO:0007744|PDB:3VP1 source Swiss-Prot : SWS_FT_FI1

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