eF-site ID 5wj6-A PDB Code 5wj6 Chain A click to enlarge Title Crystal structure of glutaminase C in complex with inhibitor 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (UPGL-00004) Classification HYDROLASE/HYDROLASE INHIBITOR Compound Glutaminase kidney isoform, mitochondrial Source (GLSK_HUMAN) Sequence A:  PSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLK ECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFR RKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKF SPDLWGVSVCTADGQRHSTGDTKVPFCLQSCVKPLKYAIA VNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNA GAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNA TFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQ LCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNT LSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVM GMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHF AKKLDPRREG Description Functional site 1) chain A residue 317 type sequence R description binding site for residue B4A A 601 source : AC1 2) chain A residue 320 type sequence K description binding site for residue B4A A 601 source : AC1 3) chain A residue 321 type sequence L description binding site for residue B4A A 601 source : AC1 4) chain A residue 322 type sequence F description binding site for residue B4A A 601 source : AC1 5) chain A residue 323 type sequence L description binding site for residue B4A A 601 source : AC1 6) chain A residue 324 type sequence N description binding site for residue B4A A 601 source : AC1 7) chain A residue 325 type sequence E description binding site for residue B4A A 601 source : AC1 8) chain A residue 394 type sequence Y description binding site for residue B4A A 601 source : AC1 9) chain A residue 317 type sequence R description binding site for residue B4A C 601 source : AC2

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