eF-site ID 5wg5-A PDB Code 5wg5 Chain A click to enlarge Title Human GRK2 in complex with Gbetagamma subunits and CCG224061 Classification TRANSFERASE Compound Beta-adrenergic receptor kinase 1 Source Homo sapiens (Human) (GBG2_BOVIN) Sequence A:  KKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFR DFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIF DSYIMKELLACSHPFSKSATEHVQGHLGPPDLFQPYIEEI CQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSV HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE TLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDL MNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFV VYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQ HKTKDKHEIDRMTLVELPDSFSPELRSLLEGLLQRDVNRR LGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPVNA ADAFDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFD TINAETDRLEARKKAKNKQLDYALGKDCIMHGYMSKMGNP FLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEE TQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAY REAQQLVQRVPKMKNKP Description Functional site 1) chain A residue 199 type sequence R description binding site for residue ZSO A 701 source : AC1 2) chain A residue 200 type sequence G description binding site for residue ZSO A 701 source : AC1 3) chain A residue 203 type sequence G description binding site for residue ZSO A 701 source : AC1 4) chain A residue 205 type sequence V description binding site for residue ZSO A 701 source : AC1 5) chain A residue 218 type sequence A description binding site for residue ZSO A 701 source : AC1 6) chain A residue 220 type sequence K description binding site for residue ZSO A 701 source : AC1 7) chain A residue 222 type sequence L description binding site for residue ZSO A 701 source : AC1 8) chain A residue 272 type sequence D description binding site for residue ZSO A 701 source : AC1 9) chain A residue 274 type sequence M description binding site for residue ZSO A 701 source : AC1 10) chain A residue 278 type sequence D description binding site for residue ZSO A 701 source : AC1 11) chain A residue 321 type sequence A description binding site for residue ZSO A 701 source : AC1 12) chain A residue 324 type sequence L description binding site for residue ZSO A 701 source : AC1 13) chain A residue 348 type sequence H description binding site for residue MG A 702 source : AC2 14) chain A residue 360 type sequence E description binding site for residue MG A 702 source : AC2 15) chain A residue 361 type sequence V description binding site for residue MG A 702 source : AC2 16) chain A residue 363 type sequence Q description binding site for residue MG A 702 source : AC2 17) chain A residue 366 type sequence V description binding site for residue MG A 702 source : AC2 18) chain A residue 368 type sequence Y description binding site for residue MG A 702 source : AC2 19) chain A residue 220 type MOD_RES sequence K description Cysteine methyl ester => ECO:0000269|PubMed:1903391 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 197-220 type prosite sequence IGRGGFGEVYGCRKADTGKMYAMK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGGFGEVYgCrkadtgkm..........YAMK source prosite : PS00107 21) chain A residue 313-325 type prosite sequence VVYRDLKPANILL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKpaNILL source prosite : PS00108

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