eF-site ID 5w9l-ABCDEFGHIJ PDB Code 5w9l Chain A, B, C, D, E, F, G, H, I, J Title MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4 Classification VIRAL PROTEIN Compound Spike glycoprotein Source (5W9L) Sequence A:  VPGEMRLASIAFNHPIQVDQLNSSYFKLSIPTNFSFGVTQ EYIQTTIQKVTVDCKQYVCNGFQKCEQLLREYGQFCSKIN QALHGANLRQDDSVRNLFASVKSSQSSPIIPGFGGDFNLT LLEPVARSAIEDLLFDKVTIADPGYMQGYDDCMQQGPASA RDLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGW TAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKLIANK FNQALGAMQTGFTTTNEAFHKVQDAVNNNAQALSKLASEL SNTFGAISASIGDIIQRLDPPEQDAQIDRLINGRLTTLNA FVAQQLVRSESAALSAQLAKDKVNECVKAQSKRSGFCGQG THIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAAN PTNCIAPVNGYFIKTEWSYTGSSFYAPEPITSLNTKYVAP QVTYQNISTNLPPPLL B:  YVDVGPDSVKSACIEVDIQQTFFDKTWPRPIDVSKADGII YPQGRTYSNITITYQGLFPYQGDHGDMYVYSAGHATGTTP QKLFVANYSQDVKQFANGFVVRIGAAANSTGTVIISPSTS ATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCG TLLRAFYCILEPRSGNHCPAGNSYTSFATYHTPATDCSDG NYNRNASLNSFKEYFNLRNCTFMYTYNITEDEILEWFGIT QTAQGVHLFSSRYVDLYGGNMFQFATLPVYDTIKYYSIIP HSIRSIQSDRKAWAAFYVYKLQPLTFLLDFSVDGYIRRAI DCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQ AEGVECDFSPLLSGTPPQVYNFKRLVFTNCNYNLTKLLSL FSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLS VSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKY SYINKCSRFLSDDRTEVPQLVNANQYSPCVSIVPSTVWED GDYYRKQLSPLEGGGWLVASGSTVAMTEQLQMGFGITVQY GTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVF QNCTAVGVRQQRFVYDAYQNLVGYYSDDGNYYCLRACVSV PVSVIYDKETKTHATLFGSVACEHISSTMSQYSRSTRSML KRRDSTYGPLQTPVGCVLGLVNSSLFVEDCKLPLGQSLCA LPDTPS C:  YVDVGPDSVKSACIEVDIQQTFFDKTWPRPIDVSKADGII YPQGRTYSNITITYQGLFPYQGDHGDMYVYSAGHATGTTP QKLFVANYSQDVKQFANGFVVRIGAAANSTGTVIISPSTS ATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCG TLLRAFYCILEPRSGNHCPAGNSYTSFATYHTPATDCSDG NYNRNASLNSFKEYFNLRNCTFMYTYNITEDEILEWFGIT QTAQGVHLFSSRYVDLYGGNMFQFATLPVYDTIKYYSIIP HSIRSIQSDRKAWAAFYVYKLQPLTFLLDFSVDGYIRRAI DCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQ AEGVECDFSPLLSGTPPQVYNFKRLVFTNCNYNLTKLLSL FSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLS VSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKY SYINKCSRFLSDDRTEVPQLVNANQYSPCVSIVPSTVWED GDYYRKQLSPLEGGGWLVASGSTVAMTEQLQMGFGITVQY GTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVF QNCTAVGVRQQRFVYDAYQNLVGYYSDDGNYYCLRACVSV PVSVIYDKETKTHATLFGSVACEHISSTMSQYSRSTRSML KRRDSTYGPLQTPVGCVLGLVNSSLFVEDCKLPLGQSLCA LPDTPS D:  VPGEMRLASIAFNHPIQVDQLNSSYFKLSIPTNFSFGVTQ EYIQTTIQKVTVDCKQYVCNGFQKCEQLLREYGQFCSKIN QALHGANLRQDDSVRNLFASVKSSQSSPIIPGFGGDFNLT LLEPVARSAIEDLLFDKVTIADPGYMQGYDDCMQQGPASA RDLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGW TAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKLIANK FNQALGAMQTGFTTTNEAFHKVQDAVNNNAQALSKLASEL SNTFGAISASIGDIIQRLDPPEQDAQIDRLINGRLTTLNA FVAQQLVRSESAALSAQLAKDKVNECVKAQSKRSGFCGQG THIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAAN PTNCIAPVNGYFIKTNNTRIVDEWSYTGSSFYAPEPITSL NTKYVAPQVTYQNISTNLPPPLL E:  QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYAIHWVKQS HAKSLEWIGVFSTYYGNTNYNQKFKGRATMTVDKSSSTAY MELARLTSEDSAIYYCARKSYYVDYVDAMDYWGQGTSVT F:  DIVLTQSPASLAVSLGQRATISCRASESVDNYGISFMNWF QQKPGQPPKLLISATSNQGSGVPARFIGSGSGTDFSLNIH PVEEDDTAMYFCQQSKEVPRTFGGGTKLEIK G:  VPGEMRLASIAFNHPIQVDQLNSSYFKLSIPTNFSFGVTQ EYIQTTIQKVTVDCKQYVCNGFQKCEQLLREYGQFCSKIN QALHGANLRQDDSVRNLFASVKSSQSSPIIPGFGGDFNLT LLEPVARSAIEDLLFDKVTIADPGYMQGYDDCMQQGPASA RDLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGW TAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKLIANK FNQALGAMQTGFTTTNEAFHKVQDAVNNNAQALSKLASEL SNTFGAISASIGDIIQRLDPPEQDAQIDRLINGRLTTLNA FVAQQLVRSESAALSAQLAKDKVNECVKAQSKRSGFCGQG THIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAAN PTNCIAPVNGYFIKTNNTRIVDEWSYTGSSFYAPEPITSL NTKYVAPQVTYQNISTNLPPPLL H:  QVQLQQSGPELVRPGVSVKISCKGSGYTFTDYAIHWVKQS HAKSLEWIGVFSTYYGNTNYNQKFKGRATMTVDKSSSTAY MELARLTSEDSAIYYCARKSYYVDYVDAMDYWGQGTSVT I:  DIVLTQSPASLAVSLGQRATISCRASESVDNYGISFMNWF QQKPGQPPKLLISATSNQGSGVPARFIGSGSGTDFSLNIH PVEEDDTAMYFCQQSKEVPRTFGGGTKLEIK J:  YVDVGPDSVKSACIEVDIQQTFFDKTWPRPIDVSKADGII YPQGRTYSNITITYQGLFPYQGDHGDMYVYSAGHATGTTP QKLFVANYSQDVKQFANGFVVRIGAAANSTGTVIISPSTS ATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCG TLLRAFYCILEPRSGNHCPAGNSYTSFATYHTPATDCSDG NYNRNASLNSFKEYFNLRNCTFMYTYNITEDEILEWFGIT QTAQGVHLFSSRYVDLYGGNMFQFATLPVYDTIKYYSIIP HSIRSIQSDRKAWAAFYVYKLQPLTFLLDFSVDGYIRRAI DCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQ AEGVECDFSPLLSGTPPQVYNFKRLVFTNCNYNLTKLLSL FSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLS VSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKY SYINKCSRFLSDDRTEVPQLVNANQYSPCVSIVPSTVWED GDYYRKQLSPLEGGGWLVASGSTVAMTEQLQMGFGITVQY GTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVF QNCTAVGVRQQRFVYDAYQNLVGYYSDDGNYYCLRACVSV PVSVIYDKETKTHATLFGSVACEHISSTMSQYSRSTRSML KRRDSTYGPLQTPVGCVLGLVNSSLFVEDCKLPLGQSLCA LPDTPS Description (1)  Spike glycoprotein, G4 VH, G4 VL Functional site 1) chain A residue 887 type SITE sequence R description Cleavage => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI2 2) chain D residue 887 type SITE sequence R description Cleavage => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI2 3) chain G residue 887 type SITE sequence R description Cleavage => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI2 4) chain C residue 244 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 5) chain C residue 410 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 6) chain C residue 487 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 7) chain C residue 592 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 8) chain C residue 619 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 9) chain C residue 719 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 10) chain J residue 66 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 11) chain J residue 104 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 12) chain J residue 125 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 13) chain J residue 155 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 14) chain J residue 166 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 15) chain J residue 222 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 16) chain J residue 236 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 17) chain J residue 244 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 18) chain J residue 410 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 19) chain J residue 487 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 20) chain J residue 592 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 21) chain J residue 619 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 22) chain J residue 719 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 23) chain A residue 774 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 785 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 25) chain A residue 870 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 26) chain A residue 1213 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 27) chain D residue 774 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 28) chain D residue 785 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 29) chain D residue 870 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 30) chain D residue 1176 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 31) chain D residue 1213 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 32) chain G residue 774 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 33) chain G residue 785 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 34) chain G residue 870 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 35) chain G residue 1176 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 36) chain G residue 1213 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 37) chain B residue 66 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 38) chain B residue 104 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 39) chain B residue 125 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 40) chain B residue 155 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 41) chain B residue 166 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 42) chain B residue 222 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 43) chain B residue 236 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 44) chain B residue 244 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 45) chain B residue 410 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 46) chain B residue 487 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 47) chain B residue 592 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 48) chain B residue 619 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 49) chain B residue 719 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 50) chain C residue 66 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 51) chain C residue 104 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 52) chain C residue 125 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 53) chain C residue 155 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 54) chain C residue 166 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 55) chain C residue 222 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3 56) chain C residue 236 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099 source Swiss-Prot : SWS_FT_FI3

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