eF-site ID 5w6z-ABDE PDB Code 5w6z Chain A, B, D, E click to enlarge Title Crystal structure of the H24W mutant of HsNUDT16 Classification HYDROLASE Compound U8 snoRNA-decapping enzyme Source (NUD16_HUMAN) Sequence A:  ARRLELGEALALGSGWRHVCWALLYAPDPGMLFGRIPLRY AILMQMRFDGRLGFPGGFVDTQDRSLEDGLNRELREELGE AAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEELLAV EAGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSF IGSAREQLLEALQDLGL B:  ARRLELGEALALGSGWRHVCWALLYAPDPGMLFGRIPLRY AILMQMRFDGRLGFPGGFVDTQDRSLEDGLNRELREELGE AAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEELLAV EAGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSF IGSAREQLLEALQDLGLLQ D:  ARRLELGEALALGSGWRHVCWALLYAPDPGMLFGRIPLRY AILMQMRFDGRLGFPGGFVDTQDRSLEDGLNRELREELGE AAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEELLAV EAGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSF IGSAREQLLEALQDLGLLQ E:  ARRLELGEALALGSGWRHVCWALLYAPDPGMLFGRIPLRY AILMQMRFDGRLGFPGGFVDTQDRSLEDGLNRELREELGE AAAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEELLAV EAGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSF IGSAREQLLEALQDLGLL Description Functional site 1) chain A residue 48 type sequence Q description binding site for residue NA A 201 source : AC1 2) chain A residue 50 type sequence R description binding site for residue NA A 201 source : AC1 3) chain A residue 136 type sequence E description binding site for residue NA A 201 source : AC1 4) chain A residue 137 type sequence V description binding site for residue NA A 201 source : AC1 5) chain A residue 24 type BINDING sequence W description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 6) chain D residue 50 type BINDING sequence R description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 7) chain D residue 57 type BINDING sequence F description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 8) chain D residue 170 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 9) chain E residue 24 type BINDING sequence W description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 10) chain E residue 50 type BINDING sequence R description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 11) chain E residue 57 type BINDING sequence F description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 12) chain E residue 170 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 50 type BINDING sequence R description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 57 type BINDING sequence F description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 170 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 24 type BINDING sequence W description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 50 type BINDING sequence R description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 57 type BINDING sequence F description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 170 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 20) chain D residue 24 type BINDING sequence W description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 59 type BINDING sequence G description BINDING => ECO:0000269|PubMed:32432673, ECO:0000305|PubMed:26121039, ECO:0007744|PDB:6X7U source Swiss-Prot : SWS_FT_FI2 22) chain B residue 59 type BINDING sequence G description BINDING => ECO:0000269|PubMed:32432673, ECO:0000305|PubMed:26121039, ECO:0007744|PDB:6X7U source Swiss-Prot : SWS_FT_FI2 23) chain D residue 59 type BINDING sequence G description BINDING => ECO:0000269|PubMed:32432673, ECO:0000305|PubMed:26121039, ECO:0007744|PDB:6X7U source Swiss-Prot : SWS_FT_FI2 24) chain E residue 59 type BINDING sequence G description BINDING => ECO:0000269|PubMed:32432673, ECO:0000305|PubMed:26121039, ECO:0007744|PDB:6X7U source Swiss-Prot : SWS_FT_FI2 25) chain A residue 76 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q6TEC1 source Swiss-Prot : SWS_FT_FI3 26) chain A residue 80 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q6TEC1 source Swiss-Prot : SWS_FT_FI3 27) chain B residue 76 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q6TEC1 source Swiss-Prot : SWS_FT_FI3 28) chain B residue 80 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q6TEC1 source Swiss-Prot : SWS_FT_FI3 29) chain D residue 76 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q6TEC1 source Swiss-Prot : SWS_FT_FI3 30) chain D residue 80 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q6TEC1 source Swiss-Prot : SWS_FT_FI3 31) chain E residue 76 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q6TEC1 source Swiss-Prot : SWS_FT_FI3 32) chain E residue 80 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q6TEC1 source Swiss-Prot : SWS_FT_FI3 33) chain A residue 99 type BINDING sequence H description BINDING => ECO:0000269|PubMed:32432673, ECO:0007744|PDB:6X7U, ECO:0007744|PDB:6X7V source Swiss-Prot : SWS_FT_FI4 34) chain A residue 173 type BINDING sequence E description BINDING => ECO:0000269|PubMed:32432673, ECO:0007744|PDB:6X7U, ECO:0007744|PDB:6X7V source Swiss-Prot : SWS_FT_FI4 35) chain B residue 99 type BINDING sequence H description BINDING => ECO:0000269|PubMed:32432673, ECO:0007744|PDB:6X7U, ECO:0007744|PDB:6X7V source Swiss-Prot : SWS_FT_FI4 36) chain B residue 173 type BINDING sequence E description BINDING => ECO:0000269|PubMed:32432673, ECO:0007744|PDB:6X7U, ECO:0007744|PDB:6X7V source Swiss-Prot : SWS_FT_FI4 37) chain D residue 99 type BINDING sequence H description BINDING => ECO:0000269|PubMed:32432673, ECO:0007744|PDB:6X7U, ECO:0007744|PDB:6X7V source Swiss-Prot : SWS_FT_FI4 38) chain D residue 173 type BINDING sequence E description BINDING => ECO:0000269|PubMed:32432673, ECO:0007744|PDB:6X7U, ECO:0007744|PDB:6X7V source Swiss-Prot : SWS_FT_FI4 39) chain E residue 99 type BINDING sequence H description BINDING => ECO:0000269|PubMed:32432673, ECO:0007744|PDB:6X7U, ECO:0007744|PDB:6X7V source Swiss-Prot : SWS_FT_FI4 40) chain E residue 173 type BINDING sequence E description BINDING => ECO:0000269|PubMed:32432673, ECO:0007744|PDB:6X7U, ECO:0007744|PDB:6X7V source Swiss-Prot : SWS_FT_FI4

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