eF-site ID 5w5y-ABCDEFGHIJKLMNOPQ
PDB Code 5w5y
Chain A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q
Title RNA polymerase I Initial Transcribing Complex
Classification TRANSCRIPTION
Compound DNA-directed RNA polymerase I subunit RPA190
Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c);
Sequence A:  MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDN
LGHPVSGGLYDLALGAFLRNLCSTCGLDEKFCPGHQGHIE
LPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLDISSTLLNELKSKRSEYVD
MAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSR
GKCDNCGMFSPKFRKDGFTKIFETALNEKQITNNRVKGST
YILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKAD
SFFMDVLVVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTS
LLIRDLNDDLSKLQKDKVSLEDRRVIFSRLMNAFVTIQND
VNAFIDSTKAQKVPIPGVKQALEKKEGLFRKHMMGKRVNY
AARSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAE
LRQAVINGPDKWPGATQIQNEDGSLVSLIGMSVEQRKALA
NQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKA
SMMGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFP
QNENARAEALNLANTDSQYLTPTSGSPVRGLIQDHISAGV
WLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPT
IFKPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNE
YWGKGSLENEVLFKDGALLCGILDKSQYGASKYGIVHSLH
EVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAE
GNKWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKR
LQEILRDNNKSGILDAVTSSKVNAITSQVVSKCVPDGTMK
KFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVP
VMVSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFH
CMAGREGLIDTAVKTSRSGYLQRCLTKQLEGVHVSYDNSI
RDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLK
KYNPSALIEHLDVESALKYSKKTLKYRKKHSPHYKQSVKY
DPVLAKYNPAKYLGSVSENFQDKLESFLDKNSKLFKSSDG
VNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
NVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADT
FCKSISKVLLSEVIDKVIVTETTAARSYVIHMRFFDNNEY
SEEYDVSKEELQNVISNQFIHLLEAAIVKEIKKQKNMNKV
QRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEK
LLMVNIVEEICRKSIIRQIPHIDRCVHPEPENGKRVLVTE
GVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARNTI
VNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQG
METSTSSFMKMSYETTCQFLTKAVLDNEREQLDSPSARIV
VGKLNNVGTGSFDVLAKVPNA
B:  RTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNA
LTEGPDGGLLNLGVKDIGEKVIFDGKPLNSNSGYLGNKLS
VSVEQVSIAKPMSNDGVSSAVERKVYPSESRQRLTSYRGK
LLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMS
PYELVQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMA
IIRPSFANRGASYSHYGIQIRSVRPDQTSQTNVLHYLNDG
QVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGND
VKDSFLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRV
VFQASPDQSDLEVGQEVLDRIVLVHLGKDGSQDKFRMLLF
MIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEK
IDEYLQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNEN
IGSKMQYFLSTGNLVSQSGLDLQQVSGYTVVAEKINFYRF
ISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDG
SPCGLLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHT
FAAGPSLCCVQIDGKIIGWVSHEQGKIIADTLRYWKVEGK
TPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYL
PLDKEDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNI
LSILANLTPFSDFNQSPRNMYQCQMGKQTMGTPGVALCHR
SDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVI
SYTGYDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRN
RGDPITQHFGFGNDEWPKEWLEKLDEDGLPYIGTYVEEGD
PICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQ
ELQTVSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDM
PFSETGIQPDIIINPHAFPSRMTIGMFVESLAGKAGALHG
IAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSG
ATGEELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLT
MQPVKGRKRHGGIRVGEMERDALIGHGTSFLLQDRLLNSS
DYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFE
DAKKLLTEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAI
PFVLKYLDSELSAMGIRL
C:  EWNVEKFKKDFEVNISSLDAREANFDLINIDTSIANAFRR
IMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVD
PDMLTWVDSNLPDDEKFTDENTIVLSLNVKCTRNPDAPKG
STDPKELYNNAHVYARDLKFEPQGRQSTTFADCPVVPADP
DILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRL
LPQINILQPIKGESARRFQKCFPPGVIGIDEGSDEAYVKD
ARKDTVSREVLRYEEFADKVKLGRVRNHFIFNVESAGAMT
PEEIFFKSVRILKNKAEYLKNCPITQ
D:  TATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENTN
LSSSISQLKRIQRDFKGLP
E:  MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLE
DFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWV
EFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDE
KRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIR
KSETSGRYASYRICM
F:  KAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDL
EGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEEL
IVD
G:  NENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYV
SLAPMYLENPLQGVMKQHLNPLVMKYNNKVGGVVLGYEGL
KILDADPLSKEDTSEKLIKITPDTPFGFTWCHVNLYVWQP
QVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWT
FVHLGHWVDSNGEPIDGKLRFTVRNVHTTGRVVSVDGTLI
S
H:  NTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDI
NVELFPVAAQDSLTVTIASSLNLRSWRPPQAGDRSLADDY
DYVMYGTAYKFEEVSKDLIAVYYSFGGLLMRLEGNYRNLN
NLKQENAYLLIRR
I:  SVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQ
FSNLKVVTTTADDAFPSSLRAKKSV
J:  MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLG
LKRYCCRRMILTHVDLIEKFLRYNPLEKR
K:  EEPDREKIKLLTQATSEDGTSASFQIVEEDHTLGNALRYV
IMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQK
GLKDLMDLCDVVESKFTEKIKSM
L:  TLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLV
QFEAR
M:  SEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKKKSE
KDEFVLHGENERLEYEGYTDSSSQASNQYVVGLFNPEKKS
IQLYKAPVLVSKVVSKSSKNLRGPKI
N:  FSIPDGFKKCKHLKNFPLNGDNKKKAKQQQVWLIKFPSNV
DISKLKSLPVDFESSTTMTIDKHDYKIMDDTDIESSLTQD
NLSNMTLLVPSESKESLKIASTAKDNAPLQFDKVFSVSET
AKIPAIDYSKVRVPRKDVPKVEGLKLEHFATGYDAEDF
O:  AXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXFFWDPTVANRLDSQYIQTASDLRNYRD
GTEIIAYASGKTGSVLNIAVLTRQNTLHLNRHNNVTSIEL
HSPIKSIKIPGASESIGRRSNLVGIITENSFQIFRIESVH
SRSCDVMVSSSEPLYFVEIDDLQVVDFAFNPWDLQQFAII
DIKGNWSIGRIPKNFNNNNKRKLQLIDNLHGTIFDPEELS
SWKRIEWFSHFQKILVFDRSKMIEIDFMNNWQTEVVQAKA
WSNIRDYKRIDDKNGILLTSREIIIVGASESNDPVRRISW
KHDLDPDDTTLRITVQKVKKPDHILLVAFVYSMRHKRIYM
HVFSHRKANLFQSLGCSTVLEIPGGTPTGIETILTLENFE
LVVDFLVKLRNSSEVYYYALSNTQNSIIVDHPEWASLFNN
ADEREKESIGALVSQIKLKERERISRVQNLIEHENSHDED
KYLQDLGYRLSIATNELLESWQKTKDESILSGSLSHSKLK
NLLENSDSFASIPEFSSLLDQFFQYYQDQDVTFIGFEKLL
HLFLHEDVPGLDIFYNKLLQCWVLVSPQAELLTKEIVKDI
IWSLARLEKPSLFEPIQNEISRSLSGPYQDIISSWDMDDI
P:  KLIGHEAKLLFLKSFQFILKRQIRWLITEMRFPKEFEHVA
KIIWLKILKTINDQPQEELKLQLHMTSTISILYLASTHLS
LPVYTCDYIKWICTAKMPYFQASEILPKSWRIQLPNYYVS
ILEGSISPFNGQLYNKIALTCGMIHFKEFFNSEISCQGLL
LKLVMQCALPPEFYFYTKQVIEFEETDIRNLTLWERTDER
HTGRVSNHAELRVLSYFMLTINWMLSFDRDRQYPLKWILS
LTESLTQRTTTSESIGRNIVKVVYPDKPTSSDYFQWSEEE
TLEFLKWMEKQFLPTQTSMEMTIDQKIARRKLYKIFPLDR
EDTHQLTFIEDLQERYAKQTPFFPPARKEAIGRLLTHIAS
QLLVDFAISKEQLKDCISRIKNACLHR
Q:  MFEVPITLTNRKFAQRRKLKYQYINYISRRFDRISKSDEE
RKFWKKYEKPEKSFEIWRTVSSQNKQPINKQKMTYHNFKK
IEKIPLRKMEIPLLHCTKENKLYFQSISRGLEPLKTSTSE
VRNYRTRHIVTLTDLLHLNVSRHNWSLAYKIFATLIRIPG
VQIKSLWGIGVEILDNLSNSSSGLDFLQWMCQIYSSKSRF
VQNINYRSIVPPFQTGSRTHTAKFAITYLWSSLINCQKSM
EPTENDLLQELIDKISEWVLTPPFMEDAEVWFIYASCHLL
KADTLSRQFVNDNKNNDLIGLDRDIKINQVIKHIHYVRTF
LKICLDKGGFAVPSRLIENQLKSFESRLY
Description (1)  DNA-directed RNA polymerase I subunit RPA190, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerases I and III subunit RPAC1, DNA-directed RNA polymerase I subunit RPA14, DNA-directed RNA polymerases I, II, and III subunit RPABC1, DNA-directed RNA polymerases I, II, and III subunit RPABC2, DNA-directed RNA polymerase I subunit RPA43, DNA-directed RNA polymerases I, II, and III subunit RPABC3, DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerases I, II, and III subunit RPABC5, DNA-directed RNA polymerases I and III subunit RPAC2, DNA-directed RNA polymerases I, II, and III subunit RPABC4, DNA-directed RNA polymerase I subunit RPA49, DNA-directed RNA polymerase I subunit RPA34, RNA polymerase I-specific transcription initiation factor RRN6, RNA polymerase I-specific transcription initiation factor RRN7, RNA polymerase I-specific transcription initiation factor RRN11/RNA Complex


Functional site

1) chain A
residue 102
type
sequence C
description binding site for residue ZN A 1701
source : AC1

2) chain A
residue 105
type
sequence C
description binding site for residue ZN A 1701
source : AC1

3) chain A
residue 233
type
sequence C
description binding site for residue ZN A 1701
source : AC1

4) chain A
residue 236
type
sequence C
description binding site for residue ZN A 1701
source : AC1

5) chain A
residue 62
type
sequence C
description binding site for residue ZN A 1702
source : AC2

6) chain A
residue 65
type
sequence C
description binding site for residue ZN A 1702
source : AC2

7) chain A
residue 72
type
sequence C
description binding site for residue ZN A 1702
source : AC2

8) chain A
residue 75
type
sequence H
description binding site for residue ZN A 1702
source : AC2

9) chain B
residue 1104
type
sequence C
description binding site for residue ZN B 1301
source : AC3

10) chain B
residue 1107
type
sequence C
description binding site for residue ZN B 1301
source : AC3

11) chain B
residue 1128
type
sequence C
description binding site for residue ZN B 1301
source : AC3

12) chain B
residue 1131
type
sequence C
description binding site for residue ZN B 1301
source : AC3

13) chain I
residue 10
type
sequence C
description binding site for residue ZN I 201
source : AC4

14) chain I
residue 13
type
sequence C
description binding site for residue ZN I 201
source : AC4

15) chain I
residue 30
type
sequence C
description binding site for residue ZN I 201
source : AC4

16) chain I
residue 33
type
sequence C
description binding site for residue ZN I 201
source : AC4

17) chain J
residue 7
type
sequence C
description binding site for residue ZN J 101
source : AC5

18) chain J
residue 10
type
sequence C
description binding site for residue ZN J 101
source : AC5

19) chain J
residue 45
type
sequence C
description binding site for residue ZN J 101
source : AC5

20) chain J
residue 46
type
sequence C
description binding site for residue ZN J 101
source : AC5

21) chain L
residue 31
type
sequence C
description binding site for residue ZN L 101
source : AC6

22) chain L
residue 34
type
sequence C
description binding site for residue ZN L 101
source : AC6

23) chain L
residue 48
type
sequence C
description binding site for residue ZN L 101
source : AC6

24) chain L
residue 51
type
sequence C
description binding site for residue ZN L 101
source : AC6

25) chain J
residue 45
type ZN_FING
sequence C
description RRN7-type
source Swiss-Prot : SWS_FT_FI1

26) chain J
residue 46
type ZN_FING
sequence C
description RRN7-type
source Swiss-Prot : SWS_FT_FI1

27) chain A
residue 102
type ZN_FING
sequence C
description RRN7-type
source Swiss-Prot : SWS_FT_FI1

28) chain A
residue 105
type ZN_FING
sequence C
description RRN7-type
source Swiss-Prot : SWS_FT_FI1

29) chain A
residue 233
type ZN_FING
sequence C
description RRN7-type
source Swiss-Prot : SWS_FT_FI1

30) chain A
residue 236
type ZN_FING
sequence C
description RRN7-type
source Swiss-Prot : SWS_FT_FI1

31) chain N
residue 60
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:18407956
source Swiss-Prot : SWS_FT_FI3

32) chain B
residue 1156
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:19779198
source Swiss-Prot : SWS_FT_FI4

33) chain J
residue 2-11
type prosite
sequence IVPVRCFSCG
description RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IVPVrCFSCG
source prosite : PS01112

34) chain F
residue 86-100
type prosite
sequence TKYERARILGTRALQ
description RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ
source prosite : PS01111

35) chain B
residue 914-926
type prosite
sequence GDKFSSRHGQKGV
description RNA_POL_BETA RNA polymerases beta chain signature. GdKFSSrHGQKGV
source prosite : PS01166

36) chain K
residue 65-96
type prosite
sequence IVEEDHTLGNALRYVIMKNPDVEFCGYSIPHP
description RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. IveEdHTLgNaLryvImknpdVefcgYsipHP
source prosite : PS01154

37) chain E
residue 147-160
type prosite
sequence HELVPKHIRLSSDE
description RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPKHirLssDE
source prosite : PS01110

38) chain C
residue 65-105
type prosite
sequence NAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLV
P
description RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NAFRRimisevpsvAaeyVyffnNtSviqDEvLAhRIGLVP
source prosite : PS00446

39) chain I
residue 9-33
type prosite
sequence FCLDCGDLLENPNAVLGSNVECSQC
description RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FClDCGDLLenpnavlgsnve..CsqC
source prosite : PS01030


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