eF-site ID 5vwq-A PDB Code 5vwq Chain A click to enlarge Title E.coli Aspartate aminotransferase-(1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP) Classification TRANSFERASE Compound Aspartate aminotransferase Source Escherichia coli (strain K12) (AAT_ECOLI) Sequence A:  MFENITAAPADPILGLADLFRADERPGKINLGIGVYKDET GKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFGRCTQE LLFGKGSALINDKRARTAQTPGGTGALRVAADFLAKNTSV KRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFD ALINSLNEAQAGDVVLFHGCCHNPTGIDPTLEQWQTLAQL SVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKELIV ASSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIR ANYSNPPAHGASVVATILSNDALRAIWEQELTDMRQRIQR MRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKEQVLR LREEFGVYAVASGRVNVAGMTPDNMAPLCEAIVAVL Description Functional site 1) chain A residue 103 type sequence G description binding site for residue PMP A 401 source : AC1 2) chain A residue 104 type sequence T description binding site for residue PMP A 401 source : AC1 3) chain A residue 130 type sequence W description binding site for residue PMP A 401 source : AC1 4) chain A residue 183 type sequence N description binding site for residue PMP A 401 source : AC1 5) chain A residue 211 type sequence D description binding site for residue PMP A 401 source : AC1 6) chain A residue 214 type sequence Y description binding site for residue PMP A 401 source : AC1 7) chain A residue 243 type sequence S description binding site for residue PMP A 401 source : AC1 8) chain A residue 245 type sequence S description binding site for residue PMP A 401 source : AC1 9) chain A residue 246 type sequence K description binding site for residue PMP A 401 source : AC1 10) chain A residue 254 type sequence R description binding site for residue PMP A 401 source : AC1 11) chain A residue 65 type sequence Y description binding site for residue PMP D 401 source : AC2 12) chain A residue 374 type BINDING sequence R description BINDING => ECO:0007744|PDB:1AHG, ECO:0007744|PDB:1AIB, ECO:0007744|PDB:1ARG, ECO:0007744|PDB:1ART, ECO:0007744|PDB:1CZE, ECO:0007744|PDB:3QPG, ECO:0007744|PDB:4DBC source Swiss-Prot : SWS_FT_FI4 13) chain A residue 246 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:11148029, ECO:0000269|PubMed:1993208, ECO:0000269|PubMed:3298240, ECO:0000269|PubMed:9891001, ECO:0007744|PDB:1AAW, ECO:0007744|PDB:1AHE, ECO:0007744|PDB:1AHF, ECO:0007744|PDB:1AHX, ECO:0007744|PDB:1AHY, ECO:0007744|PDB:1ARI, ECO:0007744|PDB:1ARS, ECO:0007744|PDB:1ASA, ECO:0007744|PDB:1ASB, ECO:0007744|PDB:1ASD, ECO:0007744|PDB:1ASE, ECO:0007744|PDB:1ASF, ECO:0007744|PDB:1ASG, ECO:0007744|PDB:1ASM, ECO:0007744|PDB:1ASN, ECO:0007744|PDB:1B4X, ECO:0007744|PDB:1CZC, ECO:0007744|PDB:1CZE, ECO:0007744|PDB:1G4V, ECO:0007744|PDB:1G4X, ECO:0007744|PDB:1G7W, ECO:0007744|PDB:1G7X, ECO:0007744|PDB:1IX6, ECO:0007744|PDB:1IX7, ECO:0007744|PDB:1IX8, ECO:0007744|PDB:1QIR, ECO:0007744|PDB:1QIS, ECO:0007744|PDB:1QIT, ECO:0007744|PDB:1YOO, ECO:0007744|PDB:2D5Y, ECO:0007744|PDB:2D61, ECO:0007744|PDB:2D63, ECO:0007744|PDB:2D7Y, ECO:0007744|PDB:3AAT, ECO:0007744|PDB:3ZZJ, ECO:0007744|PDB:5EAA source Swiss-Prot : SWS_FT_FI5 14) chain A residue 243-256 type prosite sequence SYSKNFGLYNERVG description AA_TRANSFER_CLASS_1 Aminotransferases class-I pyridoxal-phosphate attachment site. SYSKnfGLyNERVG source prosite : PS00105 15) chain A residue 130 type catalytic sequence W description 777 source MCSA : MCSA1 16) chain A residue 211 type catalytic sequence D description 777 source MCSA : MCSA1 17) chain A residue 246 type catalytic sequence K description 777 source MCSA : MCSA1 18) chain A residue 34 type BINDING sequence G description BINDING => ECO:0007744|PDB:1ART, ECO:0007744|PDB:1CZE, ECO:0007744|PDB:3QPG, ECO:0007744|PDB:4DBC source Swiss-Prot : SWS_FT_FI1 19) chain A residue 130 type BINDING sequence W description BINDING => ECO:0007744|PDB:1AIB, ECO:0007744|PDB:1ART, ECO:0007744|PDB:1CZE, ECO:0007744|PDB:1SPA, ECO:0007744|PDB:3QPG, ECO:0007744|PDB:4DBC source Swiss-Prot : SWS_FT_FI2 20) chain A residue 183 type BINDING sequence N description BINDING => ECO:0007744|PDB:1AIB, ECO:0007744|PDB:1ART, ECO:0007744|PDB:1ASC, ECO:0007744|PDB:1CZE, ECO:0007744|PDB:1SPA, ECO:0007744|PDB:3QPG, ECO:0007744|PDB:4DBC source Swiss-Prot : SWS_FT_FI3

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