eF-site ID 5vrn-E PDB Code 5vrn Chain E click to enlarge Title CRYSTAL STRUCTURE OF THE INHA FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AN12855, EBSI 4333. Classification OXIDOREDUCTASE Compound Enoyl-[acyl-carrier-protein] reductase [NADH] Source (INHA_MYCTO) Sequence E:  TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGF DRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEA IGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIH ISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWM TVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSA IVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKT VCALLSDWLPATTGDIIYADGGAHTQLL Description Functional site 1) chain E residue 14 type sequence G description binding site for residue 9JM E 300 source : AC5 2) chain E residue 15 type sequence I description binding site for residue 9JM E 300 source : AC5 3) chain E residue 16 type sequence I description binding site for residue 9JM E 300 source : AC5 4) chain E residue 20 type sequence S description binding site for residue 9JM E 300 source : AC5 5) chain E residue 21 type sequence I description binding site for residue 9JM E 300 source : AC5 6) chain E residue 41 type sequence F description binding site for residue 9JM E 300 source : AC5 7) chain E residue 63 type sequence L description binding site for residue 9JM E 300 source : AC5 8) chain E residue 64 type sequence D description binding site for residue 9JM E 300 source : AC5 9) chain E residue 65 type sequence V description binding site for residue 9JM E 300 source : AC5 10) chain E residue 94 type sequence S description binding site for residue 9JM E 300 source : AC5 11) chain E residue 95 type sequence I description binding site for residue 9JM E 300 source : AC5 12) chain E residue 96 type sequence G description binding site for residue 9JM E 300 source : AC5 13) chain E residue 122 type sequence I description binding site for residue 9JM E 300 source : AC5 14) chain E residue 147 type sequence M description binding site for residue 9JM E 300 source : AC5 15) chain E residue 148 type sequence D description binding site for residue 9JM E 300 source : AC5 16) chain E residue 149 type sequence F description binding site for residue 9JM E 300 source : AC5 17) chain E residue 165 type sequence K description binding site for residue 9JM E 300 source : AC5 18) chain E residue 193 type sequence P description binding site for residue 9JM E 300 source : AC5 19) chain E residue 194 type sequence I description binding site for residue 9JM E 300 source : AC5 20) chain E residue 196 type sequence T description binding site for residue 9JM E 300 source : AC5 21) chain E residue 20 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10336454, ECO:0000269|PubMed:16647717, ECO:0000269|PubMed:7886450, ECO:0007744|PDB:1BVR, ECO:0007744|PDB:1ENY, ECO:0007744|PDB:2AQ8 source Swiss-Prot : SWS_FT_FI1 22) chain E residue 64 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10336454, ECO:0000269|PubMed:16647717, ECO:0000269|PubMed:7886450, ECO:0007744|PDB:1BVR, ECO:0007744|PDB:1ENY, ECO:0007744|PDB:2AQ8 source Swiss-Prot : SWS_FT_FI1 23) chain E residue 95 type BINDING sequence I description BINDING => ECO:0000269|PubMed:10336454, ECO:0000269|PubMed:16647717, ECO:0000269|PubMed:7886450, ECO:0007744|PDB:1BVR, ECO:0007744|PDB:1ENY, ECO:0007744|PDB:2AQ8 source Swiss-Prot : SWS_FT_FI1 24) chain E residue 165 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10336454, ECO:0000269|PubMed:16647717, ECO:0000269|PubMed:7886450, ECO:0007744|PDB:1BVR, ECO:0007744|PDB:1ENY, ECO:0007744|PDB:2AQ8 source Swiss-Prot : SWS_FT_FI1 25) chain E residue 194 type BINDING sequence I description BINDING => ECO:0000269|PubMed:10336454, ECO:0000269|PubMed:16647717, ECO:0000269|PubMed:7886450, ECO:0007744|PDB:1BVR, ECO:0007744|PDB:1ENY, ECO:0007744|PDB:2AQ8 source Swiss-Prot : SWS_FT_FI1 26) chain E residue 158 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10336454 source Swiss-Prot : SWS_FT_FI2 27) chain E residue 149 type SITE sequence F description May act as an intermediate that passes the hydride ion from NADH to the substrate => ECO:0000305|PubMed:10336454 source Swiss-Prot : SWS_FT_FI3 28) chain E residue 158 type SITE sequence Y description Transition state stabilizer => ECO:0000305|PubMed:10521269 source Swiss-Prot : SWS_FT_FI4 29) chain E residue 266 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:20864541, ECO:0000269|PubMed:21143326 source Swiss-Prot : SWS_FT_FI5

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