eF-site ID 5vrm-B PDB Code 5vrm Chain B click to enlarge Title CRYSTAL STRUCTURE OF THE INHA FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AN12855, EBSI 4333. Classification OXIDOREDUCTASE Compound Enoyl-[acyl-carrier-protein] reductase [NADH] Source (INHA_MYCTO) Sequence B:  TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGF DRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEA IGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIH ISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWM TVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMQL LEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDI IYADGGAHTQLL Description Functional site 1) chain B residue 14 type sequence G description binding site for residue 9JJ B 300 source : AC2 2) chain B residue 15 type sequence I description binding site for residue 9JJ B 300 source : AC2 3) chain B residue 16 type sequence I description binding site for residue 9JJ B 300 source : AC2 4) chain B residue 20 type sequence S description binding site for residue 9JJ B 300 source : AC2 5) chain B residue 21 type sequence I description binding site for residue 9JJ B 300 source : AC2 6) chain B residue 41 type sequence F description binding site for residue 9JJ B 300 source : AC2 7) chain B residue 63 type sequence L description binding site for residue 9JJ B 300 source : AC2 8) chain B residue 64 type sequence D description binding site for residue 9JJ B 300 source : AC2 9) chain B residue 65 type sequence V description binding site for residue 9JJ B 300 source : AC2 10) chain B residue 94 type sequence S description binding site for residue 9JJ B 300 source : AC2 11) chain B residue 95 type sequence I description binding site for residue 9JJ B 300 source : AC2 12) chain B residue 96 type sequence G description binding site for residue 9JJ B 300 source : AC2 13) chain B residue 122 type sequence I description binding site for residue 9JJ B 300 source : AC2 14) chain B residue 147 type sequence M description binding site for residue 9JJ B 300 source : AC2 15) chain B residue 148 type sequence D description binding site for residue 9JJ B 300 source : AC2 16) chain B residue 149 type sequence F description binding site for residue 9JJ B 300 source : AC2 17) chain B residue 158 type sequence Y description binding site for residue 9JJ B 300 source : AC2 18) chain B residue 161 type sequence M description binding site for residue 9JJ B 300 source : AC2 19) chain B residue 165 type sequence K description binding site for residue 9JJ B 300 source : AC2 20) chain B residue 192 type sequence G description binding site for residue 9JJ B 300 source : AC2 21) chain B residue 193 type sequence P description binding site for residue 9JJ B 300 source : AC2 22) chain B residue 194 type sequence I description binding site for residue 9JJ B 300 source : AC2 23) chain B residue 196 type sequence T description binding site for residue 9JJ B 300 source : AC2 24) chain B residue 198 type sequence A description binding site for residue 9JJ B 300 source : AC2 25) chain B residue 199 type sequence M description binding site for residue 9JJ B 300 source : AC2 26) chain B residue 266 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:20864541, ECO:0000269|PubMed:21143326 source Swiss-Prot : SWS_FT_FI5 27) chain B residue 194 type BINDING sequence I description BINDING => ECO:0000269|PubMed:10336454, ECO:0000269|PubMed:16647717, ECO:0000269|PubMed:7886450, ECO:0007744|PDB:1BVR, ECO:0007744|PDB:1ENY, ECO:0007744|PDB:2AQ8 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 20 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10336454, ECO:0000269|PubMed:16647717, ECO:0000269|PubMed:7886450, ECO:0007744|PDB:1BVR, ECO:0007744|PDB:1ENY, ECO:0007744|PDB:2AQ8 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 64 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10336454, ECO:0000269|PubMed:16647717, ECO:0000269|PubMed:7886450, ECO:0007744|PDB:1BVR, ECO:0007744|PDB:1ENY, ECO:0007744|PDB:2AQ8 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 95 type BINDING sequence I description BINDING => ECO:0000269|PubMed:10336454, ECO:0000269|PubMed:16647717, ECO:0000269|PubMed:7886450, ECO:0007744|PDB:1BVR, ECO:0007744|PDB:1ENY, ECO:0007744|PDB:2AQ8 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 165 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10336454, ECO:0000269|PubMed:16647717, ECO:0000269|PubMed:7886450, ECO:0007744|PDB:1BVR, ECO:0007744|PDB:1ENY, ECO:0007744|PDB:2AQ8 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 158 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10336454 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 149 type SITE sequence F description May act as an intermediate that passes the hydride ion from NADH to the substrate => ECO:0000305|PubMed:10336454 source Swiss-Prot : SWS_FT_FI3 34) chain B residue 158 type SITE sequence Y description Transition state stabilizer => ECO:0000305|PubMed:10521269 source Swiss-Prot : SWS_FT_FI4

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