eF-site ID 5vmp-C PDB Code 5vmp Chain C click to enlarge Title Crystal Structure of Human KDM4 with Small Molecule Inhibitor QC5714 Classification OXIDOREDUCTASE/INHIBITOR Compound Lysine-specific demethylase 4A Source Homo sapiens (Human) (KDM4A_HUMAN) Sequence C:  ARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPK EWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKA MTVREFRKIANSDKYCTPRYFEELERKYWKNLTFNPPIYG ADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNT PYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPP EHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKY GIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFAT RRWIEYGKQAVLCSCRKISMDVFVRKFQPERYKLWKAGKT VIDHTLPTPEAAEFL Description Functional site 1) chain C residue 188 type sequence H description binding site for residue NI C 501 source : AC7 2) chain C residue 190 type sequence E description binding site for residue NI C 501 source : AC7 3) chain C residue 276 type sequence H description binding site for residue NI C 501 source : AC7 4) chain C residue 234 type sequence C description binding site for residue ZN C 502 source : AC8 5) chain C residue 240 type sequence H description binding site for residue ZN C 502 source : AC8 6) chain C residue 306 type sequence C description binding site for residue ZN C 502 source : AC8 7) chain C residue 308 type sequence C description binding site for residue ZN C 502 source : AC8 8) chain C residue 73 type sequence Q description binding site for residue 9FJ C 503 source : AC9 9) chain C residue 86 type sequence N description binding site for residue 9FJ C 503 source : AC9 10) chain C residue 132 type sequence Y description binding site for residue 9FJ C 503 source : AC9 11) chain C residue 184 type sequence S description binding site for residue 9FJ C 503 source : AC9 12) chain C residue 185 type sequence F description binding site for residue 9FJ C 503 source : AC9 13) chain C residue 188 type sequence H description binding site for residue 9FJ C 503 source : AC9 14) chain C residue 206 type sequence K description binding site for residue 9FJ C 503 source : AC9 15) chain C residue 208 type sequence W description binding site for residue 9FJ C 503 source : AC9 16) chain C residue 240 type sequence H description binding site for residue 9FJ C 503 source : AC9 17) chain C residue 276 type sequence H description binding site for residue 9FJ C 503 source : AC9 18) chain C residue 170 type catalytic sequence G description 370 source MCSA : MCSA3 19) chain C residue 177 type catalytic sequence Y description 370 source MCSA : MCSA3 20) chain C residue 188 type catalytic sequence H description 370 source MCSA : MCSA3 21) chain C residue 190 type catalytic sequence E description 370 source MCSA : MCSA3 22) chain C residue 276 type catalytic sequence H description 370 source MCSA : MCSA3 23) chain C residue 288 type catalytic sequence S description 370 source MCSA : MCSA3 24) chain C residue 241 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:B2RXH2 source Swiss-Prot : SWS_FT_FI5 25) chain C residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 26) chain C residue 198 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 27) chain C residue 206 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16677698 source Swiss-Prot : SWS_FT_FI1 28) chain C residue 188 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 29) chain C residue 276 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI2 30) chain C residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 source Swiss-Prot : SWS_FT_FI3 31) chain C residue 240 type BINDING sequence H description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 32) chain C residue 306 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 33) chain C residue 308 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4 34) chain C residue 234 type BINDING sequence C description BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I source Swiss-Prot : SWS_FT_FI4

Display surface Download Links