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eF-site ID
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5vio-C |
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PDB Code
|
5vio |
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Chain
|
C |
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click to enlarge
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Title
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Crystal structure of ASK1 kinase domain with a potent inhibitor (analog 13) |
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Classification
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TRANSFERASE/TRANSFERASE INHIBITOR |
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Compound
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Mitogen-activated protein kinase kinase kinase 5 |
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Source
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Homo sapiens (Human) (M3K5_HUMAN) |
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Sequence
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C: |
LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIK
EIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGF
IKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILE
GLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRL
AGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGC
TIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSA
EAKAFILKCFEPDPDKRACANDLLVDEFLKV
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Description
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Functional site
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|
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1)
|
chain |
C |
| residue |
814 |
| type |
|
| sequence |
Y
|
| description |
binding site for residue 9E4 D 4000
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| source |
: AC3
|
|
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2)
|
chain |
C |
| residue |
709 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
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3)
|
chain |
C |
| residue |
803 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
C |
| residue |
686 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
C |
| residue |
718 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine => ECO:0000269|PubMed:16407264
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
6)
|
chain |
C |
| residue |
813 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:17937911
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
7)
|
chain |
C |
| residue |
842 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:17937911
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
8)
|
chain |
C |
| residue |
838 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by autocatalysis, MELK and MAP3K6 => ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:17937911, ECO:0000269|PubMed:18948261, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:23102700
|
| source |
Swiss-Prot : SWS_FT_FI6
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