eF-site ID 5vil-C PDB Code 5vil Chain C click to enlarge Title Crystal structure of ASK1 kinase domain with a potent inhibitor (analog 6) Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Mitogen-activated protein kinase kinase kinase 5 Source Homo sapiens (Human) (M3K5_HUMAN) Sequence C:  LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIK EIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGF IKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILE GLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRL AGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGC TIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSA EAKAFILKCFEPDPDKRACANDLLVDEFLKV Description Functional site 1) chain C residue 686 type sequence L description binding site for residue 9E1 C 4000 source : AC7 2) chain C residue 689 type sequence G description binding site for residue 9E1 C 4000 source : AC7 3) chain C residue 707 type sequence A description binding site for residue 9E1 C 4000 source : AC7 4) chain C residue 709 type sequence K description binding site for residue 9E1 C 4000 source : AC7 5) chain C residue 738 type sequence V description binding site for residue 9E1 C 4000 source : AC7 6) chain C residue 754 type sequence M description binding site for residue 9E1 C 4000 source : AC7 7) chain C residue 755 type sequence E description binding site for residue 9E1 C 4000 source : AC7 8) chain C residue 756 type sequence Q description binding site for residue 9E1 C 4000 source : AC7 9) chain C residue 757 type sequence V description binding site for residue 9E1 C 4000 source : AC7 10) chain C residue 758 type sequence P description binding site for residue 9E1 C 4000 source : AC7 11) chain C residue 759 type sequence G description binding site for residue 9E1 C 4000 source : AC7 12) chain C residue 760 type sequence G description binding site for residue 9E1 C 4000 source : AC7 13) chain C residue 807 type sequence D description binding site for residue 9E1 C 4000 source : AC7 14) chain C residue 808 type sequence N description binding site for residue 9E1 C 4000 source : AC7 15) chain C residue 810 type sequence L description binding site for residue 9E1 C 4000 source : AC7 16) chain C residue 822 type sequence D description binding site for residue 9E1 C 4000 source : AC7 17) chain C residue 814 type sequence Y description binding site for residue 9E1 D 4000 source : AC8 18) chain C residue 803 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 19) chain C residue 686 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 20) chain C residue 709 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 21) chain C residue 718 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:16407264 source Swiss-Prot : SWS_FT_FI4 22) chain C residue 813 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:17937911 source Swiss-Prot : SWS_FT_FI5 23) chain C residue 842 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:17937911 source Swiss-Prot : SWS_FT_FI5 24) chain C residue 838 type MOD_RES sequence T description Phosphothreonine; by autocatalysis, MELK and MAP3K6 => ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:17937911, ECO:0000269|PubMed:18948261, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:23102700 source Swiss-Prot : SWS_FT_FI6

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