|
|
eF-site ID
|
5vid-ABCDFGHI |
|
PDB Code
|
5vid |
|
Chain
|
A, B, C, D, F, G, H, I |
|
click to enlarge
|
|
|
Title
|
Receptor binding domain of BoNT/B in complex with mini-protein binder Bot.0671.2 |
|
Classification
|
TOXIN |
|
Compound
|
Botulinum neurotoxin type B |
|
Source
|
Clostridium botulinum (5VID) |
|
|
Sequence
|
A: |
NIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKNQFKLT
SSANSKIRVTQSVFLDFSVSFWIRIPKYKNDGIQNYIHNE
YTIINCMKNNSGWKISIRGNRIIWTLIDINGKTKSVFFEY
NIREDISEYINRWFFVTITNNLNNAKIYINGKLESNTDIK
DIREVIANGEIIFKLDGDIDRTQFIWMKYFSIFNTELSQS
NIEERYKIQSYSEYLKDFWGNPLMYNKEYYMFNAGNKNSY
IKLKKDSPVGEILTRSKYNQNSKYINYRDLYIGEKFIIRR
KSDIVRKEDYIYLDFFNLNQEWRVYTYKYFKKEEEKLFLA
PISDSDEFYNTIQIKEYDEQPTYSCQLLFKKDEESTDEIG
LIGIHRFYESGIVFEEYKDYFCISKWYLKEVKRKPYNLKL
GCNWQFIPKDEGWTE
|
| B: |
NNIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKNQFKL
TSSANSKIRVTQNLDFSVSFWIRIPKYKNDGIQNYIHNEY
TIINCMKNNSGWKISIRGNRIIWTLIDINGKTKSVFFEYN
IREDISEYINRWFFVTITNNLNNAKIYINGKLESNTDIKD
IREVIANGEIIFKLDGDIDRTQFIWMKYFSIFNTELSQSN
IEERYKIQSYSEYLKDFWGNPLMYNKEYYMFNAGNKNSYI
KLKKDSPVGEILTRSKYNQNSKYINYRDLYIGEKFIIRRK
SSINDDIVRKEDYIYLDFFNLNQEWRVYTYKYFKKEEEKL
FLAPISDSDEFYNTIQIKEYDEQPTYSCQLLFKKDEESTD
EIGLIGIHRFYEEYKDYFCISKWYLKEVKRKPYNLKLGCN
WQFIPKDEGWTE
|
| C: |
NNIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKNQFKL
TSSANSKIRVTQNQNIISVFLDFSVSFWIRIPKYKNDGIQ
NYIHNEYTIINCMKNNSGWKISIRGNRIIWTLIDINGKTK
SVFFEYNIREDISEYINRWFFVTITNNLNNAKIYINGKLE
SNTDIKDIREVIANGEIIFKLDGDIDRTQFIWMKYFSIFN
TELSQSNIEERYKIQSYSEYLKDFWGNPLMYNKEYYMFNA
GNKNSYIKLKKDSPVGEILTRSKYNQNSKYINYRDLYIGE
KFIIRRKSQSINDDIVRKEDYIYLDFFNLNQEWRVYTYKY
FKKEEEKLFLAPISDSDEFYNTIQIKEYDEQPTYSCQLLF
KKDEESTDEIGLIGIHRFYESGIVFEEYKDYFCISKWYLK
EVKRKPYNLKLGCNWQFIPKDEGWTE
|
| D: |
NIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKNQFKLT
SSANSKIRVTQNVFLDFSVSFWIRIPKYKNDGIQNYIHNE
YTIINCMKNNSGWKISIRGNRIIWTLIDINGKTKSVFFEY
NIREDISEYINRWFFVTITNNLNNAKIYINGKLESNTDIK
DIREVIANGEIIFKLDGDIDRTQFIWMKYFSIFNTELSQS
NIEERYKIQSYSEYLKDFWGNPLMYNKEYYMFNAGNKNSY
IKLKKDSPVGEILTRSKYNQNSKYINYRDLYIGEKFIIRR
KSNSINDDIVRKEDYIYLDFFNLNQEWRVYTYKYFKKEEE
KLFLAPISDSDEFYNTIQIKEYDEQPTYSCQLLFKKDEES
TDEIGLIGIHRFYESGIVFEEYKDYFCISKWYLKEVKRKP
YNLKLGCNWQFIPKDEGWTE
|
| F: |
MFAELKAKFFLEIGDRDAARNALRKAGYSDEEAERIIRKY
|
| G: |
FAELKAKFFLEIGDRDAARNALRKAGYSDEEAERIIRKY
|
| H: |
MFAELKAKFFLEIGDRDAARNALRKSDEEAERIIRKY
|
| I: |
FAELKAKFFLEIGDRDAARNALRKAGYSDEEAERIIRKY
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
D |
| residue |
1189 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:10932256, ECO:0000305|PubMed:14731268, ECO:0007744|PDB:4KBB
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
2)
|
chain |
D |
| residue |
1240 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000269|PubMed:10932256, ECO:0000305|PubMed:14731268, ECO:0007744|PDB:4KBB
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
B |
| residue |
1189 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:10932256, ECO:0000305|PubMed:14731268, ECO:0007744|PDB:4KBB
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
B |
| residue |
1240 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000269|PubMed:10932256, ECO:0000305|PubMed:14731268, ECO:0007744|PDB:4KBB
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
C |
| residue |
1189 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:10932256, ECO:0000305|PubMed:14731268, ECO:0007744|PDB:4KBB
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
C |
| residue |
1240 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000269|PubMed:10932256, ECO:0000305|PubMed:14731268, ECO:0007744|PDB:4KBB
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
A |
| residue |
1189 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:10932256, ECO:0000305|PubMed:14731268, ECO:0007744|PDB:4KBB
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
1240 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000269|PubMed:10932256, ECO:0000305|PubMed:14731268, ECO:0007744|PDB:4KBB
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
D |
| residue |
1025 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0007744|PDB:4KBB
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
B |
| residue |
1025 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0007744|PDB:4KBB
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
11)
|
chain |
C |
| residue |
1025 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0007744|PDB:4KBB
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
12)
|
chain |
A |
| residue |
1025 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0007744|PDB:4KBB
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|