|
|
eF-site ID
|
5vfr-E |
|
PDB Code
|
5vfr |
|
Chain
|
E |
|
click to enlarge
|
|
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Title
|
Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome |
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Classification
|
HYDROLASE |
|
Compound
|
26S proteasome non-ATPase regulatory subunit 1 |
|
Source
|
(PSMD2_HUMAN) |
|
|
Sequence
|
E: |
KLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVG
QIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKP
GTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSE
IGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYG
PPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARL
IREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQ
RTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGR
LDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKL
SDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKV
ADSKKLESKLDYKPV
|
|
|
Description
|
(1) |
Activated Human 26S Proteasome
|
|
Functional site
|
|
|
1)
|
chain |
E |
| residue |
265 |
| type |
|
| sequence |
D
|
| description |
binding site for residue AGS D 501
|
| source |
: AC4
|
|
|
2)
|
chain |
E |
| residue |
291 |
| type |
|
| sequence |
R
|
| description |
binding site for residue AGS D 501
|
| source |
: AC4
|
|
|
3)
|
chain |
E |
| residue |
294 |
| type |
|
| sequence |
R
|
| description |
binding site for residue AGS D 501
|
| source |
: AC4
|
|
|
4)
|
chain |
E |
| residue |
206 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:17323924, ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
E |
| residue |
273-291 |
| type |
prosite |
| sequence |
VKMIMATNRPDTLDPALLR
|
| description |
AAA AAA-protein family signature. VkMImATNrpdtLDpALl.R
|
| source |
prosite : PS00674
|
|
|
|