eF-site ID 5vfi-A PDB Code 5vfi Chain A click to enlarge Title Bruton's tyrosine kinase (BTK) with GDC-0853 Classification Transferase/Transferase Inhibitor Compound Tyrosine-protein kinase BTK Source Homo sapiens (Human) (BTK_HUMAN) Sequence A:  GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVA IKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQR PIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEA MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLD DEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMW EIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYT IMYSCWHEKADERPTFKILLSNILDVMDEES Description Functional site 1) chain A residue 520 type sequence R description binding site for residue EDO A 702 source : AC1 2) chain A residue 522 type sequence L description binding site for residue EDO A 702 source : AC1 3) chain A residue 563 type sequence W description binding site for residue EDO A 702 source : AC1 4) chain A residue 564 type sequence S description binding site for residue EDO A 702 source : AC1 5) chain A residue 574 type sequence F description binding site for residue EDO A 702 source : AC1 6) chain A residue 578 type sequence S description binding site for residue EDO A 702 source : AC1 7) chain A residue 582 type sequence A description binding site for residue EDO A 702 source : AC1 8) chain A residue 492 type sequence R description binding site for residue EDO A 703 source : AC2 9) chain A residue 493 type sequence F description binding site for residue EDO A 703 source : AC2 10) chain A residue 572 type sequence S description binding site for residue EDO A 703 source : AC2 11) chain A residue 593 type sequence L description binding site for residue EDO A 703 source : AC2 12) chain A residue 494 type sequence Q description binding site for residue EDO A 704 source : AC3 13) chain A residue 496 type sequence Q description binding site for residue EDO A 704 source : AC3 14) chain A residue 575 type sequence S description binding site for residue EDO A 704 source : AC3 15) chain A residue 576 type sequence S description binding site for residue EDO A 704 source : AC3 16) chain A residue 476 type sequence Y description binding site for residue EDO A 705 source : AC4 17) chain A residue 477 type sequence M description binding site for residue EDO A 705 source : AC4 18) chain A residue 478 type sequence A description binding site for residue EDO A 705 source : AC4 19) chain A residue 530 type sequence N description binding site for residue EDO A 705 source : AC4 20) chain A residue 531 type sequence D description binding site for residue EDO A 705 source : AC4 21) chain A residue 495 type sequence T description binding site for residue EDO A 706 source : AC5 22) chain A residue 658 type sequence E description binding site for residue EDO A 706 source : AC5 23) chain A residue 403 type sequence T description binding site for residue EDO A 707 source : AC6 24) chain A residue 404 type sequence F description binding site for residue EDO A 707 source : AC6 25) chain A residue 627 type sequence Y description binding site for residue EDO A 707 source : AC6 26) chain A residue 628 type sequence T description binding site for residue EDO A 707 source : AC6 27) chain A residue 631 type sequence Y description binding site for residue EDO A 707 source : AC6 28) chain A residue 494 type sequence Q description binding site for residue EDO A 708 source : AC7 29) chain A residue 497 type sequence Q description binding site for residue EDO A 708 source : AC7 30) chain A residue 516 type sequence Q description binding site for residue EDO A 708 source : AC7 31) chain A residue 517 type sequence F description binding site for residue EDO A 708 source : AC7 32) chain A residue 518 type sequence L description binding site for residue EDO A 708 source : AC7 33) chain A residue 520 type sequence R description binding site for residue EDO A 708 source : AC7 34) chain A residue 598 type sequence Y description binding site for residue EDO A 709 source : AC8 35) chain A residue 599 type sequence E description binding site for residue EDO A 709 source : AC8 36) chain A residue 600 type sequence R description binding site for residue EDO A 709 source : AC8 37) chain A residue 601 type sequence F description binding site for residue EDO A 709 source : AC8 38) chain A residue 389 type sequence G description binding site for residue SO4 A 710 source : AC9 39) chain A residue 422 type sequence R description binding site for residue SO4 A 710 source : AC9 40) chain A residue 595 type sequence K description binding site for residue SO4 A 711 source : AD1 41) chain A residue 619 type sequence P description binding site for residue SO4 A 711 source : AD1 42) chain A residue 620 type sequence H description binding site for residue SO4 A 711 source : AD1 43) chain A residue 625 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI9 44) chain A residue 589 type MOD_RES sequence E description Phosphoserine => ECO:0000269|PubMed:15375214 source Swiss-Prot : SWS_FT_FI8 45) chain A residue 408-430 type prosite sequence LGTGQFGVVKYGKWRGQYDVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGQFGVVKyGkwrgqyd...........VAIK source prosite : PS00107 46) chain A residue 517-529 type prosite sequence FLHRDLAARNCLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCLV source prosite : PS00109 47) chain A residue 487 type ACT_SITE sequence R description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 396 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 49) chain A residue 440 type BINDING sequence D description BINDING => ECO:0000269|PubMed:20052711, ECO:0007744|PDB:3K54, ECO:0007744|PDB:3OCT source Swiss-Prot : SWS_FT_FI3 50) chain A residue 508 type BINDING sequence A description BINDING => ECO:0000269|PubMed:21280133, ECO:0007744|PDB:3PIY source Swiss-Prot : SWS_FT_FI4 51) chain A residue 517 type MOD_RES sequence F description Phosphotyrosine; by LYN and SYK => ECO:0000269|PubMed:8630736, ECO:0000269|PubMed:9012831 source Swiss-Prot : SWS_FT_FI5 52) chain A residue 570 type MOD_RES sequence M description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 53) chain A residue 583 type MOD_RES sequence F description Phosphotyrosine => ECO:0000269|PubMed:15375214 source Swiss-Prot : SWS_FT_FI7

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