eF-site ID 5vdh-D PDB Code 5vdh Chain D click to enlarge Title Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607, Glycine, and Ivermectin Classification TRANSPORT PROTEIN Compound Glycine receptor subunit alpha-3 Source (GLRA3_HUMAN) Sequence D:  SRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCN IFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDS LDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFK NGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYT MNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHY NTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSF WINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKA IDIWMAVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKI DTISRACFPLAFLIFNIFYWVIY Description Functional site 1) chain D residue 223-244 type TRANSMEM sequence YLIQMYIPSLLIVILSWVSFWI description Helical; Name=1 => ECO:0000269|PubMed:26416729 source Swiss-Prot : SWS_FT_FI2 2) chain D residue 245-249 type TOPO_DOM sequence NMDAA description Cytoplasmic => ECO:0000269|PubMed:26416729 source Swiss-Prot : SWS_FT_FI3 3) chain D residue 250-270 type TRANSMEM sequence PARVALGITTVLTMTTQSSGS description Helical; Name=2 => ECO:0000269|PubMed:26416729 source Swiss-Prot : SWS_FT_FI4 4) chain D residue 282-302 type TRANSMEM sequence AIDIWMAVCLLFVFSALLEYA description Helical; Name=3 => ECO:0000269|PubMed:26416729 source Swiss-Prot : SWS_FT_FI5 5) chain D residue 325-345 type TRANSMEM sequence ISRACFPLAFLIFNIFYWVIY description Helical; Name=4 => ECO:0000269|PubMed:26416729 source Swiss-Prot : SWS_FT_FI6 6) chain D residue 192 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P23415 source Swiss-Prot : SWS_FT_FI7 7) chain D residue 194 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P23415 source Swiss-Prot : SWS_FT_FI7 8) chain D residue 215 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:P23415 source Swiss-Prot : SWS_FT_FI7 9) chain D residue 202 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:26416729 source Swiss-Prot : SWS_FT_FI8 10) chain D residue 261 type SITE sequence L description Important for obstruction of the ion pore in the closed conformation => ECO:0000269|PubMed:26416729 source Swiss-Prot : SWS_FT_FI9 11) chain D residue 271-281 type TOPO_DOM sequence RASLPKVSYVK description Extracellular => ECO:0000269|PubMed:26416729 source Swiss-Prot : SWS_FT_FI1 12) chain D residue 38 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:26416729, ECO:0007744|PDB:5CFB source Swiss-Prot : SWS_FT_FI10

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