eF-site/Summary 5vdh-C

eF-site ID	5vdh-C
PDB Code	5vdh
Chain	C

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Title	Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607, Glycine, and Ivermectin
Classification	TRANSPORT PROTEIN
Compound	Glycine receptor subunit alpha-3
Source	(GLRA3_HUMAN)

Sequence	C:	MSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINS FGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDP SMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVL YSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLI FEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKF TCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMD AAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWM AVCLLFVFSALLEYAAVNFVSRAGTKVFIDRAKKIDTISR ACFPLAFLIFNIFYWVIY

Description

Functional site


1)	chain	C
	residue	223-244
	type	TRANSMEM
	sequence	YLIQMYIPSLLIVILSWVSFWI
	description	Helical; Name=1 => ECO:0000269\|PubMed:26416729
	source	Swiss-Prot : SWS_FT_FI2

2)	chain	C
	residue	245-249
	type	TOPO_DOM
	sequence	NMDAA
	description	Cytoplasmic => ECO:0000269\|PubMed:26416729
	source	Swiss-Prot : SWS_FT_FI3

3)	chain	C
	residue	250-270
	type	TRANSMEM
	sequence	PARVALGITTVLTMTTQSSGS
	description	Helical; Name=2 => ECO:0000269\|PubMed:26416729
	source	Swiss-Prot : SWS_FT_FI4

4)	chain	C
	residue	282-302
	type	TRANSMEM
	sequence	AIDIWMAVCLLFVFSALLEYA
	description	Helical; Name=3 => ECO:0000269\|PubMed:26416729
	source	Swiss-Prot : SWS_FT_FI5

5)	chain	C
	residue	325-345
	type	TRANSMEM
	sequence	ISRACFPLAFLIFNIFYWVIY
	description	Helical; Name=4 => ECO:0000269\|PubMed:26416729
	source	Swiss-Prot : SWS_FT_FI6

6)	chain	C
	residue	192
	type	BINDING
	sequence	E
	description	BINDING => ECO:0000250\|UniProtKB:P23415
	source	Swiss-Prot : SWS_FT_FI7

7)	chain	C
	residue	194
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000250\|UniProtKB:P23415
	source	Swiss-Prot : SWS_FT_FI7

8)	chain	C
	residue	215
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000250\|UniProtKB:P23415
	source	Swiss-Prot : SWS_FT_FI7

9)	chain	C
	residue	202
	type	BINDING
	sequence	Y
	description	BINDING => ECO:0000269\|PubMed:26416729
	source	Swiss-Prot : SWS_FT_FI8

10)	chain	C
	residue	261
	type	SITE
	sequence	L
	description	Important for obstruction of the ion pore in the closed conformation => ECO:0000269\|PubMed:26416729
	source	Swiss-Prot : SWS_FT_FI9

11)	chain	C
	residue	271-281
	type	TOPO_DOM
	sequence	RASLPKVSYVK
	description	Extracellular => ECO:0000269\|PubMed:26416729
	source	Swiss-Prot : SWS_FT_FI1

12)	chain	C
	residue	38
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269\|PubMed:26416729, ECO:0007744\|PDB:5CFB
	source	Swiss-Prot : SWS_FT_FI10