eF-site ID 5v58-A
PDB Code 5v58
Chain A

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Title Crystal structure of human prolyl-tRNA synthetase in complex with Aze-SA
Classification LIGASE
Compound Bifunctional glutamate/proline--tRNA ligase
Source (SYEP_HUMAN)
Sequence A:  RLGLEAKKEENLADWYSQVITKSEMIEYHDISGCYILRPW
AYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKA
PEVAWVTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHR
DLPIKLNQWCNVVRWEFKHPQPFLRTREFLWQEGHSAFAT
MEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTEKEKFAG
GDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFED
PKIPGEKQFAYQNSWGLTTRTIGVMTMVHGDNMGLVLPPR
VACVQVVIIPCSEEDKEALIAKCNDYRRRLLSVNIRVRAD
LRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRR
DTGEKLTVAENEAETKLQAILEDIQVTLFTRASEDLKTHM
VVANTMEDFQKILDSGKIVQIPFCGEIDCEDWIKKTTARD
MGAKSLCIPFKPLCELAKCVCGKNPAKYYTLFGRSY
Description


Functional site
1) chain A
residue 1121
type
sequence T
description binding site for residue 8X1 A 1601
source : AC1
2) chain A
residue 1123
type
sequence E
description binding site for residue 8X1 A 1601
source : AC1
3) chain A
residue 1152
type
sequence R
description binding site for residue 8X1 A 1601
source : AC1
4) chain A
residue 1154
type
sequence E
description binding site for residue 8X1 A 1601
source : AC1
5) chain A
residue 1161
type
sequence F
description binding site for residue 8X1 A 1601
source : AC1
6) chain A
residue 1162
type
sequence L
description binding site for residue 8X1 A 1601
source : AC1
7) chain A
residue 1164
type
sequence T
description binding site for residue 8X1 A 1601
source : AC1
8) chain A
residue 1167
type
sequence F
description binding site for residue 8X1 A 1601
source : AC1
9) chain A
residue 1169
type
sequence W
description binding site for residue 8X1 A 1601
source : AC1
10) chain A
residue 1237
type
sequence Q
description binding site for residue 8X1 A 1601
source : AC1
11) chain A
residue 1239
type
sequence G
description binding site for residue 8X1 A 1601
source : AC1
12) chain A
residue 1240
type
sequence T
description binding site for residue 8X1 A 1601
source : AC1
13) chain A
residue 1242
type
sequence H
description binding site for residue 8X1 A 1601
source : AC1
14) chain A
residue 1274
type
sequence G
description binding site for residue 8X1 A 1601
source : AC1
15) chain A
residue 1276
type
sequence T
description binding site for residue 8X1 A 1601
source : AC1
16) chain A
residue 1278
type
sequence R
description binding site for residue 8X1 A 1601
source : AC1
17) chain A
residue 1448
type
sequence C
description binding site for residue ZN A 1602
source : AC2
18) chain A
residue 1453
type
sequence C
description binding site for residue ZN A 1602
source : AC2
19) chain A
residue 1495
type
sequence C
description binding site for residue ZN A 1602
source : AC2
20) chain A
residue 1497
type
sequence C
description binding site for residue ZN A 1602
source : AC2
21) chain A
residue 1500
type
sequence N
description binding site for residue ZN A 1602
source : AC2
22) chain A
residue 1121
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:24100331, ECO:0007744|PDB:4K87
source Swiss-Prot : SWS_FT_FI1
23) chain A
residue 1152
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:24100331, ECO:0007744|PDB:4K87
source Swiss-Prot : SWS_FT_FI1
24) chain A
residue 1242
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:24100331, ECO:0007744|PDB:4K87
source Swiss-Prot : SWS_FT_FI1
25) chain A
residue 1154
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K87, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S
source Swiss-Prot : SWS_FT_FI2
26) chain A
residue 1163
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K87, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S
source Swiss-Prot : SWS_FT_FI2
27) chain A
residue 1164
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K87, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S
source Swiss-Prot : SWS_FT_FI2
28) chain A
residue 1240
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K87, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S
source Swiss-Prot : SWS_FT_FI2
29) chain A
residue 1276
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K87, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S
source Swiss-Prot : SWS_FT_FI2
30) chain A
residue 1237
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:37212275, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S
source Swiss-Prot : SWS_FT_FI3
31) chain A
residue 1278
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:37212275, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S
source Swiss-Prot : SWS_FT_FI3
32) chain A
residue 1448
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K86, ECO:0007744|PDB:4K87, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S
source Swiss-Prot : SWS_FT_FI4
33) chain A
residue 1453
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K86, ECO:0007744|PDB:4K87, ECO:0007744|PDB:4K88, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S
source Swiss-Prot : SWS_FT_FI5
34) chain A
residue 1495
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K86, ECO:0007744|PDB:4K87, ECO:0007744|PDB:4K88, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S
source Swiss-Prot : SWS_FT_FI5
35) chain A
residue 1497
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K86, ECO:0007744|PDB:4K87, ECO:0007744|PDB:4K88, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S
source Swiss-Prot : SWS_FT_FI5
36) chain A
residue 1152
type MOD_RES
sequence R
description Omega-N-methylarginine => ECO:0007744|PubMed:24129315
source Swiss-Prot : SWS_FT_FI6
37) chain A
residue 1350
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI7
38) chain A
residue 1503
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI8

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