eF-site ID 5v48-A
PDB Code 5v48
Chain A

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Title Soluble rabbit neprilysin in complex with thiorphan
Classification HYDROLASE
Compound Neprilysin
Source (NEP_RABIT)
Sequence A:  GICKSSDCIKSAARLIQNMDATAEPCTDFFKYACGGWLKR
NVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQ
KAKTLYRSCVNETAIDSRGGQPLLKLLPDVYGWPVATQNW
EQTYGTSWSAEKSIAQLNSKYGKKVLINFFVGTDDKNSMN
HIIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMIAVAK
LIRQEEGLPIDENQISVEMNKVMELEKEIANATTKSEDRN
DPMLLYNKMTLAQIQNNFSLEINGKPFSWSNFTNEIMSTV
NINIPNEEDVVVYAPEYLIKLKPILTKYSPRDLQNLMSWR
FIMDLVSSLSRTYKDSRNAFRKALYGTTSESATWRRCANY
VNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQT
LDDLTWMDAETKKKAEEKALAIKERIGYPDDIVSNDNKLN
NEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDE
WITGAAIVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLN
YGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANN
FKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGG
IGQAYRAYQNYVKKNGEEKLLPGIDLNHKQLFFLNFAQVW
CGTYRPEYAVNSIKTDVHSPGNFRIIGSLQNSVEFSEAFQ
CPKNSYMNPEKKCRVW
Description


Functional site

1) chain A
residue 581-590
type prosite
sequence VIGHEITHGF
description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEITHGF
source prosite : PS00142

2) chain A
residue 585
type ACT_SITE
sequence E
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000255|PROSITE-ProRule:PRU10095
source Swiss-Prot : SWS_FT_FI1

3) chain A
residue 651
type ACT_SITE
sequence D
description Proton donor => ECO:0000255|PROSITE-ProRule:PRU01233
source Swiss-Prot : SWS_FT_FI2

4) chain A
residue 103
type BINDING
sequence R
description BINDING => ECO:0000250|UniProtKB:P07861
source Swiss-Prot : SWS_FT_FI3

5) chain A
residue 584
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000305|PubMed:3162886
source Swiss-Prot : SWS_FT_FI4

6) chain A
residue 588
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000305|PubMed:3162886
source Swiss-Prot : SWS_FT_FI4

7) chain A
residue 647
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01233
source Swiss-Prot : SWS_FT_FI5

8) chain A
residue 145
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000250|UniProtKB:P08473
source Swiss-Prot : SWS_FT_FI6

9) chain A
residue 311
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000250|UniProtKB:P08473
source Swiss-Prot : SWS_FT_FI6

10) chain A
residue 325
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000250|UniProtKB:P08473
source Swiss-Prot : SWS_FT_FI6

11) chain A
residue 285
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI7

12) chain A
residue 628
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine
source Swiss-Prot : SWS_FT_FI8


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