eF-site ID 5upe-A PDB Code 5upe Chain A click to enlarge Title Crystal structure of human NAMPT with isoindoline urea inhibitor compound 5 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Nicotinamide phosphoribosyltransferase Source Homo sapiens (Human) (NAMPT_HUMAN) Sequence A:  FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFY GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKG WNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPE CYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDT VAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKD AFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKG YKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAF GSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHT VFKNGKVTKSYSFDEIRKNAQLNI Description Functional site 1) chain A residue 188 type sequence Y description binding site for residue 8HY A 901 source : AC1 2) chain A residue 191 type sequence H description binding site for residue 8HY A 901 source : AC1 3) chain A residue 193 type sequence F description binding site for residue 8HY A 901 source : AC1 4) chain A residue 196 type sequence R description binding site for residue 8HY A 901 source : AC1 5) chain A residue 219 type sequence D description binding site for residue 8HY A 901 source : AC1 6) chain A residue 242 type sequence V description binding site for residue 8HY A 901 source : AC1 7) chain A residue 244 type sequence A description binding site for residue 8HY A 901 source : AC1 8) chain A residue 275 type sequence S description binding site for residue 8HY A 901 source : AC1 9) chain A residue 307 type sequence P description binding site for residue 8HY A 901 source : AC1 10) chain A residue 311 type sequence R description binding site for residue 8HY A 901 source : AC1 11) chain A residue 351 type sequence I description binding site for residue 8HY A 901 source : AC1 12) chain A residue 379 type sequence A description binding site for residue 8HY A 901 source : AC1 13) chain A residue 18 type sequence Y description binding site for residue 8HY B 501 source : AC2 14) chain A residue 472 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 15) chain A residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 16) chain A residue 219 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 17) chain A residue 247 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 18) chain A residue 311 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 19) chain A residue 353 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 20) chain A residue 384 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 21) chain A residue 392 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 22) chain A residue 188 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI3

Display surface Download Links