eF-site ID 5ucj-B PDB Code 5ucj Chain B click to enlarge Title Hsp90b N-terminal domain with inhibitors Classification Chaperone/Inhibitor Compound Heat shock protein HSP 90-beta Source Homo sapiens (Human) (HS90B_HUMAN) Sequence B:  GHMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEI FLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPN PQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQ AGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWE SSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRV KEVVKKHSQFIGYPITLYL Description Functional site 1) chain B residue 43 type sequence L description binding site for residue KU3 B 301 source : AC4 2) chain B residue 46 type sequence N description binding site for residue KU3 B 301 source : AC4 3) chain B residue 50 type sequence A description binding site for residue KU3 B 301 source : AC4 4) chain B residue 53 type sequence K description binding site for residue KU3 B 301 source : AC4 5) chain B residue 88 type sequence D description binding site for residue KU3 B 301 source : AC4 6) chain B residue 91 type sequence I description binding site for residue KU3 B 301 source : AC4 7) chain B residue 92 type sequence G description binding site for residue KU3 B 301 source : AC4 8) chain B residue 93 type sequence M description binding site for residue KU3 B 301 source : AC4 9) chain B residue 133 type sequence F description binding site for residue KU3 B 301 source : AC4 10) chain B residue 179 type sequence T description binding site for residue KU3 B 301 source : AC4 11) chain B residue 181 type sequence V description binding site for residue KU3 B 301 source : AC4 12) chain B residue 17 type sequence F description binding site for residue DMS B 302 source : AC5 13) chain B residue 18 type sequence Q description binding site for residue DMS B 302 source : AC5 14) chain B residue 19 type sequence A description binding site for residue DMS B 302 source : AC5 15) chain B residue 130 type sequence G description binding site for residue DMS B 303 source : AC6 16) chain B residue 131 type sequence V description binding site for residue DMS B 303 source : AC6 17) chain B residue 134 type sequence Y description binding site for residue DMS B 303 source : AC6 18) chain B residue 46 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 133 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 88 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 22) chain B residue 126 type SITE sequence I description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402 source Swiss-Prot : SWS_FT_FI3

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