eF-site ID 5ucj-ABCD PDB Code 5ucj Chain A, B, C, D click to enlarge Title Hsp90b N-terminal domain with inhibitors Classification Chaperone/Inhibitor Compound Heat shock protein HSP 90-beta Source Homo sapiens (Human) (HS90B_HUMAN) Sequence A:  HMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIF LRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNP QERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQA GADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWES SAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVK EVVKKHSQFIGYPITLYL B:  GHMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEI FLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPN PQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQ AGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWE SSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRV KEVVKKHSQFIGYPITLYL C:  EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASD ALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDT GIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQF GVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRA DHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFI GYPITLYL D:  EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASD ALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDT GIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQF GVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRA DHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFI GYPITLYL Description Functional site 1) chain A residue 43 type sequence L description binding site for residue KU3 A 301 source : AC1 2) chain A residue 46 type sequence N description binding site for residue KU3 A 301 source : AC1 3) chain A residue 47 type sequence A description binding site for residue KU3 A 301 source : AC1 4) chain A residue 50 type sequence A description binding site for residue KU3 A 301 source : AC1 5) chain A residue 53 type sequence K description binding site for residue KU3 A 301 source : AC1 6) chain A residue 88 type sequence D description binding site for residue KU3 A 301 source : AC1 7) chain A residue 91 type sequence I description binding site for residue KU3 A 301 source : AC1 8) chain A residue 92 type sequence G description binding site for residue KU3 A 301 source : AC1 9) chain A residue 93 type sequence M description binding site for residue KU3 A 301 source : AC1 10) chain A residue 133 type sequence F description binding site for residue KU3 A 301 source : AC1 11) chain A residue 179 type sequence T description binding site for residue KU3 A 301 source : AC1 12) chain A residue 181 type sequence V description binding site for residue KU3 A 301 source : AC1 13) chain A residue 16 type sequence A description binding site for residue DMS A 302 source : AC2 14) chain A residue 17 type sequence F description binding site for residue DMS A 302 source : AC2 15) chain C residue 17 type sequence F description binding site for residue DMS A 302 source : AC2 16) chain C residue 18 type sequence Q description binding site for residue DMS A 302 source : AC2 17) chain C residue 19 type sequence A description binding site for residue DMS A 302 source : AC2 18) chain A residue 101 type sequence N description binding site for residue DMS A 303 source : AC3 19) chain A residue 102 type sequence L description binding site for residue DMS A 303 source : AC3 20) chain A residue 130 type sequence G description binding site for residue DMS A 303 source : AC3 21) chain A residue 133 type sequence F description binding site for residue DMS A 303 source : AC3 22) chain A residue 134 type sequence Y description binding site for residue DMS A 303 source : AC3 23) chain B residue 43 type sequence L description binding site for residue KU3 B 301 source : AC4 24) chain B residue 46 type sequence N description binding site for residue KU3 B 301 source : AC4 25) chain B residue 50 type sequence A description binding site for residue KU3 B 301 source : AC4 26) chain B residue 53 type sequence K description binding site for residue KU3 B 301 source : AC4 27) chain B residue 88 type sequence D description binding site for residue KU3 B 301 source : AC4 28) chain B residue 91 type sequence I description binding site for residue KU3 B 301 source : AC4 29) chain B residue 92 type sequence G description binding site for residue KU3 B 301 source : AC4 30) chain B residue 93 type sequence M description binding site for residue KU3 B 301 source : AC4 31) chain B residue 133 type sequence F description binding site for residue KU3 B 301 source : AC4 32) chain B residue 179 type sequence T description binding site for residue KU3 B 301 source : AC4 33) chain B residue 181 type sequence V description binding site for residue KU3 B 301 source : AC4 34) chain B residue 17 type sequence F description binding site for residue DMS B 302 source : AC5 35) chain B residue 18 type sequence Q description binding site for residue DMS B 302 source : AC5 36) chain B residue 19 type sequence A description binding site for residue DMS B 302 source : AC5 37) chain D residue 16 type sequence A description binding site for residue DMS B 302 source : AC5 38) chain D residue 17 type sequence F description binding site for residue DMS B 302 source : AC5 39) chain D residue 18 type sequence Q description binding site for residue DMS B 302 source : AC5 40) chain B residue 130 type sequence G description binding site for residue DMS B 303 source : AC6 41) chain B residue 131 type sequence V description binding site for residue DMS B 303 source : AC6 42) chain B residue 134 type sequence Y description binding site for residue DMS B 303 source : AC6 43) chain C residue 43 type sequence L description binding site for residue KU3 C 301 source : AC7 44) chain C residue 46 type sequence N description binding site for residue KU3 C 301 source : AC7 45) chain C residue 47 type sequence A description binding site for residue KU3 C 301 source : AC7 46) chain C residue 49 type sequence D description binding site for residue KU3 C 301 source : AC7 47) chain C residue 50 type sequence A description binding site for residue KU3 C 301 source : AC7 48) chain C residue 53 type sequence K description binding site for residue KU3 C 301 source : AC7 49) chain C residue 88 type sequence D description binding site for residue KU3 C 301 source : AC7 50) chain C residue 92 type sequence G description binding site for residue KU3 C 301 source : AC7 51) chain C residue 93 type sequence M description binding site for residue KU3 C 301 source : AC7 52) chain C residue 133 type sequence F description binding site for residue KU3 C 301 source : AC7 53) chain C residue 179 type sequence T description binding site for residue KU3 C 301 source : AC7 54) chain C residue 181 type sequence V description binding site for residue KU3 C 301 source : AC7 55) chain C residue 101 type sequence N description binding site for residue DMS C 302 source : AC8 56) chain C residue 106 type sequence A description binding site for residue DMS C 302 source : AC8 57) chain C residue 130 type sequence G description binding site for residue DMS C 302 source : AC8 58) chain C residue 134 type sequence Y description binding site for residue DMS C 302 source : AC8 59) chain D residue 43 type sequence L description binding site for residue KU3 D 301 source : AC9 60) chain D residue 46 type sequence N description binding site for residue KU3 D 301 source : AC9 61) chain D residue 50 type sequence A description binding site for residue KU3 D 301 source : AC9 62) chain D residue 53 type sequence K description binding site for residue KU3 D 301 source : AC9 63) chain D residue 88 type sequence D description binding site for residue KU3 D 301 source : AC9 64) chain D residue 91 type sequence I description binding site for residue KU3 D 301 source : AC9 65) chain D residue 92 type sequence G description binding site for residue KU3 D 301 source : AC9 66) chain D residue 93 type sequence M description binding site for residue KU3 D 301 source : AC9 67) chain D residue 133 type sequence F description binding site for residue KU3 D 301 source : AC9 68) chain D residue 179 type sequence T description binding site for residue KU3 D 301 source : AC9 69) chain D residue 181 type sequence V description binding site for residue KU3 D 301 source : AC9 70) chain D residue 101 type sequence N description binding site for residue DMS D 302 source : AD1 71) chain D residue 130 type sequence G description binding site for residue DMS D 302 source : AD1 72) chain D residue 134 type sequence Y description binding site for residue DMS D 302 source : AD1 73) chain A residue 33-42 type prosite sequence YSNKEIFLRE description HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE source prosite : PS00298 74) chain D residue 46 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 75) chain D residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 76) chain D residue 133 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 77) chain C residue 133 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 78) chain A residue 46 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 79) chain A residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 80) chain A residue 133 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 81) chain B residue 46 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 82) chain B residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 83) chain B residue 133 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 84) chain C residue 46 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 85) chain C residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 86) chain A residue 88 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 87) chain B residue 88 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 88) chain C residue 88 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 89) chain D residue 88 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 90) chain A residue 126 type SITE sequence I description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402 source Swiss-Prot : SWS_FT_FI3 91) chain B residue 126 type SITE sequence I description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402 source Swiss-Prot : SWS_FT_FI3 92) chain C residue 126 type SITE sequence I description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402 source Swiss-Prot : SWS_FT_FI3 93) chain D residue 126 type SITE sequence I description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402 source Swiss-Prot : SWS_FT_FI3

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